Results of a randomized controlled trial on the efficacy of psychotherapy program for treatment of co-dependence in relatives of patients with opioid addiction are presented. The study included 142 people, 96 male and 46 female, mean age 26.3±2.1 years. Efficacy of treatment was estimated by the portion of patients in remission and psychometric data. A positive effect of the program on the stabilization of remission of drug addiction, recovery of social functioning and strengthening of the motivation to stay clean was demonstrated.