Role and place of biochemical markers in diagnosis of cerebral ischemic stroke

Dambinova S.A.; Skoromets A.A.; Skoromets A.P.; Skoromets T.A.; Shumilina M.V.

doi:https://doi.org/

Dambinova S.A.

Akademicheskaia gruppa akad. RAMN A.A. Skoromtsa (Universitet Émori - Atlanta, SShA);
Sankt-Peterburgskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.P. Pavlova

Skoromets A.A.

Sankt-Peterburgskiĭ gosudarstvennyĭ meditsinskiĭ institut im. akad. I.P. Pavlova

Skoromets A.P.

Akademicheskaia gruppa akad. RAMN A.A. Skoromtsa (Universitet Émori - Atlanta, SShA);
Sankt-Peterburgskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.P. Pavlova

ORCID: 0000-0001-7439-2690

Skoromets T.A.

Akademicheskaia gruppa akad. RAMN A.A. Skoromtsa (Universitet Émori - Atlanta, SShA);
Sankt-Peterburgskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.P. Pavlova

Shumilina M.V.

Akademicheskaia gruppa akad. RAMN A.A. Skoromtsa (Universitet Émori - Atlanta, SShA);
Sankt-Peterburgskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.P. Pavlova

Scopus AuthorID: 6507018914
ORCID: 0000-0001-7439-2690

Role and place of biochemical markers in diagnosis of cerebral ischemic stroke

Authors:

Dambinova S.A., Skoromets A.A., Skoromets A.P., Skoromets T.A., Shumilina M.V.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2010;110(9‑2): 24‑29

Read: 3036 times

Download PDF (RU)

Contact the author

Table of contents

To cite this article:

Dambinova SA, Skoromets AA, Skoromets AP, Skoromets TA, Shumilina MV. Role and place of biochemical markers in diagnosis of cerebral ischemic stroke. S.S. Korsakov Journal of Neurology and Psychiatry. 2010;110(9‑2):24‑29. (In Russ.)

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))

Использование инфографики авторами научных работ

Close metadata

Abstract:

In recent years neurologists pay special attention to biochemical markers of instrumental diagnosis of brain ischemia in its acute phase. Determination of specific biomarkers in the blood of patients at early stages of cerebral blood circulation disorders may be helpful in screening patients at high risk of stroke in the short-term period. We present a review of literature and an analysis of own data (over 200 patients) with chronic and acute cerebral blood circulation disorders on the possibility of using brain biomarkers in clinical practice. The diagnostic value of NR2-antibodies in stroke with ischemic volume 5-70 cm³ is approximately 95,9% and in transitory ischemic attacks - 98%.

Keywords:

instrumental diagnosis ischemic stroke

biomarkers for cerebral ischemia

NR2-peptide

NR2-antibodies

Authors:

Dambinova S.A.

Akademicheskaia gruppa akad. RAMN A.A. Skoromtsa (Universitet Émori - Atlanta, SShA);
Sankt-Peterburgskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.P. Pavlova

Skoromets A.A.

Sankt-Peterburgskiĭ gosudarstvennyĭ meditsinskiĭ institut im. akad. I.P. Pavlova

Skoromets A.P.

Akademicheskaia gruppa akad. RAMN A.A. Skoromtsa (Universitet Émori - Atlanta, SShA);
Sankt-Peterburgskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.P. Pavlova

ORCID: 0000-0001-7439-2690

Skoromets T.A.

Akademicheskaia gruppa akad. RAMN A.A. Skoromtsa (Universitet Émori - Atlanta, SShA);
Sankt-Peterburgskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.P. Pavlova

Shumilina M.V.

Akademicheskaia gruppa akad. RAMN A.A. Skoromtsa (Universitet Émori - Atlanta, SShA);
Sankt-Peterburgskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.P. Pavlova

Scopus AuthorID: 6507018914
ORCID: 0000-0001-7439-2690

Close metadata

References:

Mackay J., Mensah G. The Atlas of Heart Disease and Stroke. World Health Organization 2004; 50-51.
Gusev E.I., Skvortsova V.I. Ishemiya golovnogo mozga. M: Meditsina 2001; 327.
Dambinova S.A., Skoromets A.A.,Gromova L.G., Ilyukhina A.Yu. Uroven' autoantitel k fragmentu glutamatnogo retseptora NMDA-tipa u bol'nykh s ostrym narusheniem mozgovogo krovoobrashcheniya. Neirokhimiya 1998; 14: 4: 420-422.
Ilyukhina A.Yu. Dinamika nakopleniya autoantitel k glutamatnym retseptoram NMDA-tipa v krovi bol'nykh v ostrom periode tserebral'nogo insul'ta: Avtoref. dis. … kand. med. nauk.St-Peterburg 1998; 23.
Skoromets A.A., Dambinova S.A., Ilyukhina A.Yu., Sorokoumov V.A. Autoantitela k glutamatnym retseptoram NMDA-tipa v krovi patsientov s ostrym ishemicheskim i gemorragicheskim insul'tom. Zhurn nevrol i psikhiat 1997; 97: 6: 53-58.
Skoromets A.P. Infektsionnye porazheniya nervnoi sistemy u novorozhdennykh: Avtoref. dis. … d-ra med. nauk. St-Peterburg 2001; 70.
Skoromets T.A. Vtorichnaya ishemiya golovnogo mozga v ostrom periode cherepno-mozgovoi travmy: Avtoref. dis. … d-ra med. nauk. St-Peterburg 2002; 42.
Glynn T., Tews M., Izykenova G. et al. The clinical utility of serum NR2 peptide assay in the diagnosis of patients presenting to the emergency department with acute cerebrovascular ischemic events. Ann Emerg Med 2007; 50: 35: Abstract 107.
Albers G.W., Caplan L.R., Easton J.D. et al. Transient ischemic attack-proposal for a new definition. N Engl J Med 2002; 347: 21: 1713-1716.
Dambinova S.A., Khunteev G.A., Olson D.A. et al. NR2 peptide indicates transient ischemic attack and acute ischemic stroke. Int J Stroke 2008; 3: 153-154.
Bokesch P.M., Izykenova G.A., Justice J.B. et al. NMDA receptor antibodies predict adverse neurological outcome after cardiac surgery in high-risk patients. Stroke 2006; 37: 1432-1436.
Brightwell R.E., Sherwood R.A., Athanasiou T. et al. The neurological morbidity of carotid revascularisation: using markers of cellular brain injury to compare CEA and CAS. Eur J Vasc Endovasc Surg 2007; 34: 552-560.
Whiteley W., Tseng M.C., Sandercock P. Blood biomarkers in the diagnosis of ischemic stroke. A systematic review. Stroke 2008; 39: 2902-2909.
Gingrich M.D., Traynelis S.F. Serine proteases and brain damage-is there a link? Trends Neurosci 2000; 23: 399-407.
Dambinova S.A., Khounteev G.A., Izykenova G.A. et al. Blood test detecting autoantibodies to N-methyl-d-aspartate neuroreceptors for evaluation of patients with transient ischemic attack and stroke. Clin Chem 2003; 49: 1752-1762.
Dambinova S.A., Khounteev G.A., Skoromets A.A. Multiple panel of markers for TIA/stroke evaluation [Letter]. Stroke 2002; 33: 1181-1182.
Dambinova S.A. Brain Biomarkers for Cerebral Ischemia: NMDA Receptor Degradation and Blood Assay Development. AACC Press. Forthcoming.
Weissman J.D., Khunteev G.A., Olson D. et al. NR2 peptide levels correlate with acute cortical stroke volume and may detect reversible ischemia. Stroke 2007; 38: 494.
Dambinova S.A., Brightwell R.E., Khunteev G.A., Cheshire N.J. NR2 peptide correlates with acute cerebrovascular events after carotid revascularization. Submitted to Stroke.