Neurological deficit following cortical stroke in rats with functional hemispheric asymmetry

Volkov A.I.; Lebedev S.V.; Starykh E.P.; Volkova N.A.; Chekhonin V.P.

doi:https://doi.org/

Volkov A.I.

Gosudarstvennyĭ nauchnyĭ tsentr sotsial'noĭ i sudebnoĭ psikhiatrii im. V.P. Serbskogo

Lebedev S.V.

Gosudarstvennyĭ nauchnyĭ tsentr sotsial'noĭ i sudebnoĭ psikhiatrii im. V.P. Serbskogo

Starykh E.P.

Gosudarstvennyĭ nauchnyĭ tsentr sotsial'noĭ i sudebnoĭ psikhiatrii im. V.P. Serbskogo

Volkova N.A.

kafedra nevrologii i neĭrokhirurgii, problemnaia nauchno-issledovatel'skaia laboratoriia po izucheniiu narusheniĭ mozgovogo krovoobrashcheniia Rossiĭskogo gosudarstvennogo meditsinskogo universiteta, Moskva

Chekhonin V.P.

Otdel fundamental'noĭ i prikladnoĭ neĭrobiologii FGBU "Gosudarstvennyĭ nauchnyĭ tsentr sotsial'noĭ i sudebnoĭ psikhiatrii im. V.P. Serbskogo";
Kafedra meditsinskikh nanobiotekhnologiĭ Rossiĭskogo gosudarstvennogo meditsinskogo universiteta im. N.I. Pirogova

Neurological deficit following cortical stroke in rats with functional hemispheric asymmetry

Authors:

Volkov A.I., Lebedev S.V., Starykh E.P., Volkova N.A., Chekhonin V.P.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2010;110(9‑2): 57‑62

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To cite this article:

Volkov AI, Lebedev SV, Starykh EP, Volkova NA, Chekhonin VP. Neurological deficit following cortical stroke in rats with functional hemispheric asymmetry. S.S. Korsakov Journal of Neurology and Psychiatry. 2010;110(9‑2):57‑62. (In Russ.)

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))

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Abstract:

We evaluated the effect of "sidedness" of focal stroke induced by pial blood vessel devascularization in sensorimotor cortex of right or left hemisphere on neurological deficit in rats. Animals were preliminary examined for paw preference (hemispheric "dominance") by means of food reaching test. Data of cylinder-test, vibrissae-elicited forelimb placing test and swimming task (forepaw inhibition test) were assessed to monitor functional deficit weekly for 8 weeks after stroke. No difference between rats with right or left cortical damage was observed during the experiment. Rats with ischemia in "dominant" hemisphere performed significantly better than those with "nondominant" hemisphere lesion. The revealed effect of functional brain asymmetry on the neurological rehabilitation after stroke should be considered in design of preclinical investigation of new therapeutic approaches to stroke.

Keywords:

ischemic stroke in sensorimotor cortex of rat

functional hemispheric asymmetry

neurological deficit

Authors:

Volkov A.I.

Gosudarstvennyĭ nauchnyĭ tsentr sotsial'noĭ i sudebnoĭ psikhiatrii im. V.P. Serbskogo

Lebedev S.V.

Gosudarstvennyĭ nauchnyĭ tsentr sotsial'noĭ i sudebnoĭ psikhiatrii im. V.P. Serbskogo

Starykh E.P.

Gosudarstvennyĭ nauchnyĭ tsentr sotsial'noĭ i sudebnoĭ psikhiatrii im. V.P. Serbskogo

Volkova N.A.

Chekhonin V.P.

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References:

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