The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 101-59-87
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2024
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Ulashchik V.S.

Institut fiziologii NAN Belarusi, Minsk, Respublika Belarus'

Electroporation: characteristics and therapeutic application of the method (a review)

Authors:

Ulashchik V.S.

More about the authors

Journal: Problems of Balneology, Physiotherapy and Exercise Therapy. 2016;93(4): 66‑73

DOI: 10.17116/kurort201646-73

Views: 6595

Downloaded: 1269

Download PDF (RU)
Contact the author
Table of contents

To cite this article:

Ulashchik VS. Electroporation: characteristics and therapeutic application of the method (a review). Problems of Balneology, Physiotherapy and Exercise Therapy. 2016;93(4):66‑73. (In Russ.)
https://doi.org/10.17116/kurort201646-73

Подписка 2025 (Problems of Balneology, Physiotherapy and Exercise Therapy)
 
МСФ на ЯМ
Close metadata
Recommended articles:
FGF23 tumor indu­ced osteomalacia with loca­lization of neoplasm in the tympanic cavity. Russian Bulletin of Otorhinolaryngology. 2023;(6):91-96
Pathology of the kidneys in mali­gnant tumors of various loca­lizations and anti­tumor therapy. Russian Journal of Archive of Pathology. 2024;(3):59-66

The article briefly summarizes the currently available information on electroporation and electroporation-based therapy. We consider the definition and the biophysical basis of the method as well as the possible mechanisms underlying the formation of pores under the influence of the application of a pulsed electric field. The characteristics of the devices for electroporation are described and the most typical examples of the use of electroporation and electrochemotherapy in experimental and clinical oncology, dermatology, cosmetology, and other fields of medicine are provided.

Keywords:

electroporation
electroporation therapy
electroporator
electrochemotherapy
tumor
the therapeutic application of electroporation

Authors:

Ulashchik V.S.

Institut fiziologii NAN Belarusi, Minsk, Respublika Belarus'

List of references:

  1. Rompe JD. Extracorporale Stoβwellentherapie. Grundlagen, Indication, Anwendung. Weinheim; 1997.
  2. Ulashhik V. Extracorporeal shock wave therapy: new directions of application. Zdravoohranenie. 2010;(6):28-32. (In Russ.)
  3. Uzdenskij A. Celular and molecular mechanisms of photodynamic therapy. M.: Nauka; 2010:321. (In Russ.)
  4. Ulashhik V. Photodynamic therapy and its application in clinical medicine. Zdravoohranenie. 2006;(6):24-28. (In Russ.)
  5. Meacham JM, Durvasula K, Degertekin FL, Fedorov AG. Physical methods for intracellular delivery:practical aspects from laboratory use to industrial-scale processing. J Lab Autom. 2014;9(1):1-18.
  6. Barry BW. Novel mechanisms and devices to enable successful transdermal drug delivery. Eur J Pharm Sci. 2001;14(2):101-114.
  7. Tiwary AK, Sapra B, Jain S. Innovations in transdermal drug delivery: formulations and techniques. Recent Pat Drug Deliv Formul. 2007;1(1):23-36.
  8. Watanabe H, Nagoshi T, Suzuki S, Kobayashi M, Usa M, Inaba H. Chemiluminescence in the crude extracts of soybean seedlings. Postulated mechanism on the formation of hydroperoxide intermediates. Biochim Biophys Acta. 1992;1117(2):107-113.
  9. Labas YA, Matz MV, Zakhartchenko VA. On the origin of bioluminescent systems. Pros. of the 11 Intern. Sympos. on Bioluminescence and Chemoluminescence. Singapore; 2000:91-94.
  10. Meshherskij M, Kaaba S, Sokolovskaja A, Moskovcev A, Blohin D, Andrijanov Ju, Kubatiev A. A new method for the combined electroporation and sonoporation with reduced stress-inducing effects on cells. Patogenez. 2012;10(2):59-67. (In Russ.)
  11. Rabussay D, Widera G. Electroporation therapy. Electroporation Мediated Drug. 2002;2(3):34-40.
  12. Moroz V, Bogushevich M, Chernysh A, Kozlova E, Sharakshanje A. Experimental investigation of the effects of different forms of defibrillating pulses on biological membranes. Bjulleten' jeksperimental'noj biologii i mediciny. 2004;137(2):140-144. (In Russ.)
  13. Ostapenko O, Bojcov A, Baranov A, Lesina E, Mihajlov V, Baranov V. Dependence of the efficacy of transfecting muscle fibers in vivo on electroporation conditions. Genetika. 2004;40(1):41-48. (In Russ.)
  14. Lombry E, Dujardin N, Preat V. Transdermal delivery of macromolecules using skin electroporation. Pharm Res. 2000;17(1):32-37.
  15. Weaver JC. Electroporation - a general phenomenon for manipulating cells and tissues. J Cell Biochem. 1993;51(4):426-435.
  16. Antonov V. Lipid pores: stability аnd permeability оf membrane. Sorosovskij obrazovatel'nyj zhurnal. 1998;(10):10-17. (In Russ.)
  17. Powell KT, Weaver JC. Transient aqueous pores in bilayer membranes: A statistical theory. Bioelectrochem Bioenergetic. 1986;15(Suppl 2):211-227.
  18. Plequett U, Langer R, Weaver JC. Changes in the passive electrical properties of human stratum corneum due to electroporation. Biochim Biophys Acta. 1995;1239(2):111-121.
  19. Hohlov A, Shugajlo V, Kononenko V, Kostenko S. Cell electroporator. Nauchnoe priborostroenie. 2007;17(4):79-81. (In Russ.)
  20. Byhovec I. Development and research of electroporator. Aktual'nye problemy transportnoj mediciny. 2011;(2):519-520. (In Russ.)
  21. Jakovenko S, Forsberg Je, Betthauzer Dzh, Tverdislov V. Permeabilization of cell membrane by programmed form of electrical pulses. Biofizika. 2004;49(1):79-87. (In Russ.)
  22. Nikitin V. Methods of substances and organelles introduction in living cell for cell engineering technologies. Citologija. 2007;49(8):631-641. (In Russ.)
  23. Gehl J. Electroporation: theory and methods, perspectives for drug delivery, gene therapy and research. Acta Physiol Scand. 2003;177(4):437-447.
  24. Heller LC, Heller L. In vivo Electroporation for gene therapy. Hum Gene Ther. 2006;17(9):890-897.
  25. Bax BE, Bain MD, Fairbanks LD et al. In vitro and in vivo studies with human carrier erythrocytes loaded with polyethylene glycol-conjugated and native adenosine deaminase. Br J Haematol. 2000;109(3):549-554.
  26. Sarbash V, Tihonova A, Vujmo T, Derbov A, Aleksandrovich Ju, Butylin A, Vitvickij V, Ataullahanov F. Red blood cells as drug carriers. Rossijskij himicheskij zhurnal. 2007;51(1):143-149. (In Russ.)
  27. Okino M, Mohri H. Effects of a high-voltage electrical impulse and an anticancer drug on in vivo growing tumor. Jpn J Cancer Res. 1987;78(12):1319-1321.
  28. Dev S, Hofman G, Gilbert R, Hajakava J, Heller R, Jarozeski M. A method of treatment by means of introduction of drugs and genes by electroporation. Patent RUS na izobretenie №2168337 ot 10.06.01. (In Russ.)
  29. Mizgireuv I, Anikin I, Mayorova I. Experimental electrochemotherapy of transplanted tumors. Sovremennye tehnologii. 2002;(5):33.
  30. Lucas ML, Heller L, Coppola D, Heller RI. L-12 plasmid delivery by in vivo electroporation for the successful treatment of established subcutaneous B16.F10 melanoma. Mol Ther. 2002;5(6):668-675.
  31. Spugnini EP, Pizzuto M, Filipponi M., Romani L, Vincenzi B, Menicagli F, Lanza A, De Girolamo R, Lomonaco R, Fanciulli M, Spriano G, Baldi A. Electroporation Enhances Bleomycin Efficacy in cats with Periocular Carcinoma and Advanced Squamous Cell Carcinoma of the Head. J Vet Intern Med. 2015;29(5):1368-1375.
  32. Panchenkov D, Ivanov Ju, Pikunov D, Zabozlaev F, Nechunaev A, Kochieva M, Aleksanjan G. Irreversible electroporation of colorectal liver metastases with the «nanoknife» system. Klinicheskaja praktika. 2013;(1):37-42. (In Russ.)
  33. Guo Y, Zhang Y, Klein R., Nijm GM, Sahakian AV, Omary RA, Yang GY, Larson AC. Irreversible electroporation therapy in the liver: longitudinal efficacy studies in rat model of hepatocellular carcinoma. Cancer Res. 2010;70(4):1555-1563.
  34. Kingham TP, Karkar AM, D' Angelica M.I, Allen PJ, Dematteo RP, Getrajdman GI, Sofocleous CT, Solomon SB, Jarnagin WR, Fong Y. Ablation of perivascular hepatic malignant tumors with irreversible electroporation. J Am Coll Surg. 2012;215(3):379-387.
  35. Sugimoto K, Moriyasu F, Kobayashi Y, Saito K, Takeuchi H, Ogawa S, Ando M, Sano T, Mori T, Furuichi Y, Nakamura I. Irreversible electroporation for nonthermal tumor ablation in patients with hepatocellular carcinoma: initial clinical experience in Japan. Jpn J Radiol. 2015;33(7):424-432.
  36. Cheng RG, Bhattacharya R, Yen MM, Padia SA. Irreversible electroporation can effectively ablate hepatocellular carcinoma to complete pathologic necrosis. J Vasc Intern Radiol. 2015;26(8):1184-1188.
  37. Narayanan G, Froud T, Suthar R, Barbery K. Irreversible electroporation of hepatic malignancy. Semin Intervent Radiol. 2013;30(1):67-73.
  38. Martin RS, Schwartz E, Adams J, Farah I, Derhake BM. Intraoperative Anestesia Management in Patients Undergoing Surgical Irreversible Electroporation of the Pancreas, Liver, Kidney and Retroperitoneal Tumors. Anesth Pain Med. 2015;5(3):e22786.
  39. Yeung ES, Chung MW, Wong K, Wong CY, So EC, Chan AC. An update on irreversible electroporation of liver tumors. Hong Kong Med J. 2014;20(4):313-316.
  40. Silk MT, Wimmer T, Lee KS, Srimathveeravalli G, Brown KT, Kingham PT, Fong Y, Durack JC, Sofocleous CT, Solomon SB. Percutaneous ablation of peribiliary tumors with irreversible electroporation. J Vasc Interv Radiol. 2014;25(1):112-118.
  41. Reinhold U. Electrochemotherapy of skin tumors. Hautarzt. 2011;62(7):549-558.
  42. Tafuto S, von Arx C, De Divitiis C, Maura CT, Palaia R, Albino V, Fusco R, Membrini M, Petrillo A, Granata V, Izzo F; ENETS Center of Excellence Multidisciplinary Group for Neuroendocrine Tumors in Naples (Italy). Electrochemotherapy as a new approach on pancreatic cancer and liver metastases. Int J Surg. 2015;21 Suppl 1:S78-82.
  43. Martin RC. Use of irreversible electroporation in unresectable pancreatic cancer. Hepatobiliary Surg Nutr. 2015;4(3):211-215.
  44. Rombouts SJ, Vogel JA, van Santvoort HC, van Lienden KP, van Hillegersberg R, Busch OR, Besselink MG, Molenaar IQ. Systematic review of innovative ablative therapies for the treatment of locally advanced pancreatic cancer. Br J Surg. 2015;102(3):182-193.
  45. Kwon D, McFarland K, Velanovich V, Martin RC. Borderline and locally advanced pancreatic adenocarcinoma margin accentuation with intraoperative irreversible electroporation. Surgery. 2014;156(4):910-920.
  46. Wendler JJ, Porsch M, Nitschke S, Köllermann J, Siedentopf S, Pech M, Fischbach F, Ricke J, Schostak M, Liehr UB. A prospective Phase II pilot study investigating focal percutaneous irreversible electroporation (IRE) ablation by NanoKnife in patients with localized renal cell carcinoma (RCC) with delayed interval tumour resection (IRENE trial). Contemp Clin Trials. 2015;43:10-19.
  47. Wendler JJ, Ganzer R, Hadaschik B, Blana A, Henkel T, Köhrmann KU, Machtens S, Roosen A, Salomon G, Sentker L, Witzsch U, Schlemmer HP, Baumunk D, Köllermann J, Schostak M, Liehr UB; Working Group for Focal and Microtherapy, Academy of the German Society of Urology. Irreversible electroporation: Current value fur focal treatment of prostate cancer. Urologe. 2015;54(6):854-862.
  48. Van den Bos W, de Bruin DM, Muller BG, Varkarakis IM, Karagiannis AA, Zondervan PJ, Laguna Pes MP, Veelo DP, Savci Heijink CD, Engelbrecht MR, Wijkstra H, de Reijke TM, de la Rosette JJ. The safety and efficacy of irreversible electroporation for the ablation of prostate cancer: a multicentre prospective human in vivo pilot study protocol. BMJ Open. 2014;4(10):e006382.
  49. Campana LG, Testori A, Mozzillo N, Rossi CR.Treatment of metastatic melanoma with electrochemotherapy. J Surg Oncol. 2014;109(4):301-307.
  50. Queirolo P, Marincola F, Spagnolo F. Electrochemotherapy for the management of melanoma skin metastasis: a review of the literature and possible combinations with immunotherapy. Arch Dermatol Res. 2014;306(6):521-526.
  51. Miclavčic D, Serša G, Brecelj E, Gehl J, Soden D, Bianchi G, Ruggieri P, Rossi CR, Campana LG, Jarm T. Electrochemotherapy: technological advancements for efficient electroporation-based treatment of internal tumors. Med Biol Eng Comput. 2012;50(12):1213-1225.
  52. Rabussay DP, Nanda GS, Goldfarb PM. Enhancing the effectiveness of drug-based cancer therapy by electroporation (electropermeabilization). Technol Cancer Res Treat. 2002;1(1):71-82.
  53. Jarm T, Cemazar M, Miklavčic D, Sersa G. Antivascular effects of electrochemotherapy: implications in treatment of bleeding metastases. Expert Rev Anticancer Ther. 2010;10(5):729-746.
  54. Tobinaga S, Matsumoto K, Nagayasu T, Furukawa K, Abo T, Yamasaki N, Tsuchiya T, Miyazaki T, Koji T. Keratinocyte Growth Factor Gene Electroporation into Skeletal Muscle as a Novel Gene Therapeutic Approach for Elastase-Induced Pulmonary Emphysema in Mice. Acta Histochem Cytochem. 2015;48(3):83-94.
  55. Wong SS, Hui JW, Chan AW, Chu CM, Rowlands DK, Yu SC. Irreversible Electroporation of the Femoral Neurovascular Bundle: Imaging and Histologic Evaluation in a Swine Model. J Vasc Interv Radiol. 2015;26(8):1212-1220.
  56. Kamimura K, Liu D. Physical approaches for nucleic acid delivery to liver. AAPS J. 2008;10(4):589-595.
  57. Rabussay D, Widera G, Burian G. Electroporation therapy: treatment of cancer and other therapeutic applications. In: Rosch P, Markov M, eds. Bioelectromagnetic medicine. New York; 2004:620-626.
  58. Haritonova E, Korol'kova T, Bezuglyj A. Using zinc hyaluronate for the treatment of androgenetic alopecia. Klinicheskaja dermatologija i venerologija. 2013;(3):19-22. (In Russ.)
  59. Chekman I, Koljadenko E, Zvjaginceva T, Syirova A. Drug delivery: dermatological aspect. Ukrainskij zhurnal dermatologii, venerologii, kosmetologii. 2010;(3):20-27. (In Russ.)
  60. Banga AK, Bose S, Ghosh TK. Iontophoresis and electroporation: comparisons and contrasts. Int J Pharmac. 1999;179(1):1-19.
  61. Kost J, Pliquett U, Mitragotri S, Yamamoto A, Langer R, Weaver J. Synergistic effect of electric field and ultrasound on transdermal transport. Pharm Res. 1996;13(4):633-638.
  62. Silk M, Tahour D, Srimathveeravalli G, Solomon SB, Thornton RH. The state of irreversible electroporation in interventional oncology. Semin Intervent Radiol. 2014;31(2):111-117.
  63. Reed SD, Li S. Electroporation advances in large animals. Curr Gene Ther. 2009;9(4):316-326.
  64. Deipolyi AR, Golberg A, Yarmush ML, Arellano RS, Oklu R. Irreversible electroporation: evolution of a laboratory technique in interventional oncology. Diagn Interv Radiol. 2014;20(2):147-154.
  65. Miklavčic D, Mali B, Kos B, Heller R, Serša G. Electrotherapy:from the drawing board into medical practice. Biomed Eng Online. 2014;13(1):29.
  66. Lakshmanan S, Gupta GK, Avci P, Chandran R, Sadasivam M, Jorge AE, Hamblin MR. Physical energy for drug delivery; poration, concentration and activation. Adv Drug Deliv Res. 2014;71:98-114.
  67. Schoellhammer CM, Blankschtein D, Langer R. Skin permiabilization for transdermal drug delivery: recent advances and future prospects. Expert Opin Drug Deliv. 2014;11(3):393-407.

Close metadata

Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register


We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.