The present article summarizes the results of experimental studies on the hepatotropic action of native and modified low-mineralized sodium chloride and bicarbonate waters differing in the content of humic acids. It was found that the most beneficial changes after a course of 21 day therapy with the use of such mineral waters for the treatment of experimental hepatitis were observed after the application of the water with a humic acid content of roughly 20 g/dm3. Such treatment resulted in the significant improvement of the liver antitoxic function, intensification of basal metabolism, reduction of the inflammatory processes, normalization of the hepatic enzyme activity, and stimulation of proteinsynthetic function in parallel with positive dynamics of the morphological and histochemical characteristics of the liver.