The specific immunophenotypic features of nasopharyngeal carcinoma

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Demyashkin G.A.

Sechenov First Moscow State Medical University, Moscow, Russia;
Scientific Clinical Center of Russian Railways, Moscow, Russia

Kastyro I.V.

Department of Otorhinolaryngology of the Medical Institute, Russian University of People’s Friendship, Moscow, Russia, 117198;
Department of Histology, Cytology and Embryology of the Medical Institute, Russian University of People’s Friendship, Moscow, Russia, 117198

Sidorin A.V.

A.F. Tsyb Medical Radiology Research Center, National Medical Radiology Research Center, Ministry of Health of Russia, Obninsk, Russia

Borisov Ya.S.

Faculty of General Medicine, N.I.Pirogov Russian National Research Medical University, Department of Otorhinolaryngology, Ministry of Health of the Russian Federation, Moscow, Russia

The specific immunophenotypic features of nasopharyngeal carcinoma

Authors:

Demyashkin G.A., Kastyro I.V., Sidorin A.V., Borisov Ya.S.

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Journal: Russian Bulletin of Otorhinolaryngology. 2018;83(5): 40‑44

DOI: 10.17116/otorino20188305140

Views: 5657

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To cite this article:

Demyashkin GA, Kastyro IV, Sidorin AV, Borisov YaS. The specific immunophenotypic features of nasopharyngeal carcinoma. Russian Bulletin of Otorhinolaryngology. 2018;83(5):40‑44. (In Russ.)
https://doi.org/10.17116/otorino20188305140

Подписка 2025 (Russian Bulletin of Otorhinolaryngology)

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We have undertaken the retrospective analysis of the medical histories of 119 patients presenting with nasopharyngeal carcinoma (NPC) and the biopsy specimens obtained from them; the wereinvestigated with the use of the histological (staining of the micropreparations with hematoxylin and eosin) and immunehistochemical (monoclonal murine antibodies against Pan-cytokeratin, CK 5/6, EBV, CK7, CK19, p16) techniques. The study has demonstrated the presence of non-differentiated nasopharyngeal carcinoma in 97 patients, diffuse large-cell B-lymphoma in 18 ones, melanoma of the nasopharyngeal mucous membrane in 2, and nasopharyngeal rhabdosarcoma in 1 patient. The immunohistochemical study revealed co-expression of the markers of Epstein—Barr virus, Pan-cytokeratin, and CK 5/6 in the non-differentiated nasopharyngeal carcinoma .

Keywords:

nasopharyngeal carcinoma

nasopharyngeal B-lymphopma

Authors:

Demyashkin G.A.

Sechenov First Moscow State Medical University, Moscow, Russia;
Scientific Clinical Center of Russian Railways, Moscow, Russia

Kastyro I.V.

Department of Otorhinolaryngology of the Medical Institute, Russian University of People’s Friendship, Moscow, Russia, 117198;
Department of Histology, Cytology and Embryology of the Medical Institute, Russian University of People’s Friendship, Moscow, Russia, 117198

Sidorin A.V.

A.F. Tsyb Medical Radiology Research Center, National Medical Radiology Research Center, Ministry of Health of Russia, Obninsk, Russia

Borisov Ya.S.

Faculty of General Medicine, N.I.Pirogov Russian National Research Medical University, Department of Otorhinolaryngology, Ministry of Health of the Russian Federation, Moscow, Russia

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