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Krasitskaya V.V.

Krasnoyarsk Research Centre of the Siberian Division of the Russian Academy of Sciences, Krasnoyarsk, Russia, 660036

Bashmakova E.E.

Krasnoyarsk Research Centre of the Siberian Division of the Russian Academy of Sciences, Krasnoyarsk, Russia, 660036

Dobretsov K.G.

Tsentr otorinolaringologii Sibirskogo klinicheskogo tsentra Rossii, Krasnoiarsk

Orlova N.V.

The Centre for Otorhinolaryngology, Federal Siberian Research and Clinical Centre, Federal Medico-Biological Agency, Krasnoyarsk, Russia, 660037

Frank L.A.

Krasnoyarsk Research Centre of the Siberian Division of the Russian Academy of Sciences, Krasnoyarsk, Russia, 660036

The genetic aspects of occupational hearing impairment

Authors:

Krasitskaya V.V., Bashmakova E.E., Dobretsov K.G., Orlova N.V., Frank L.A.

More about the authors

Journal: Russian Bulletin of Otorhinolaryngology. 2017;82(5): 71‑76

DOI: 10.17116/otorino201782571-76

Views: 1090

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To cite this article:

Krasitskaya VV, Bashmakova EE, Dobretsov KG, Orlova NV, Frank LA. The genetic aspects of occupational hearing impairment. Russian Bulletin of Otorhinolaryngology. 2017;82(5):71‑76. (In Russ.)
https://doi.org/10.17116/otorino201782571-76

Подписка 2025 (Russian Bulletin of Otorhinolaryngology)
 
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This article was designed to be the overview of the current literature publications concerning the identification of the genetic markers of susceptibility to the noise-induced loss of hearing. The analysis of these data has demonstrated that the major gene polymorphisms associated with the development of this pathological condition are localized in the genes encoding for the antioxidant systems, potassium homeostasis, and adhesion molecules as well as in the genes involved in intercellular coupling, the mechanisms underlying the cellular response to stress, activation and regulation of heat shock proteins, and signaling function of the immune system. It is concluded that the further investigations into the genetic aspects of the full-genome sequencing techniques and the search for genomic associations could greatly contribute to the development of personalized medicine and the reduction of risks of occupational noise-induced sensorineural impairment of hearing.

Keywords:

noise-induced impairment of hearing
association studies
single-nucleotide polymorphisms
metabolic pathways

Authors:

Krasitskaya V.V.

Krasnoyarsk Research Centre of the Siberian Division of the Russian Academy of Sciences, Krasnoyarsk, Russia, 660036

Bashmakova E.E.

Krasnoyarsk Research Centre of the Siberian Division of the Russian Academy of Sciences, Krasnoyarsk, Russia, 660036

Dobretsov K.G.

Tsentr otorinolaringologii Sibirskogo klinicheskogo tsentra Rossii, Krasnoiarsk

Orlova N.V.

The Centre for Otorhinolaryngology, Federal Siberian Research and Clinical Centre, Federal Medico-Biological Agency, Krasnoyarsk, Russia, 660037

Frank L.A.

Krasnoyarsk Research Centre of the Siberian Division of the Russian Academy of Sciences, Krasnoyarsk, Russia, 660036

List of references:

  1. Silkina AV, Nakatis YaA. The modern approach to the problem of noiseinduced hearing loss (literature review). Rossiiskaya otorinolaringologiya. 2016;4(83):97-102. (In Russ.)
  2. Pankova VB, Sineva EL, Preobrazhenskaia EA. Problems of diagnostics and expert examination of working capacity in subjects with occupational loss of hearing. Vestnik otorinolaringologii. 2009;6:30-33. (In Russ.)
  3. Sineva EL, Fedina IN, Preobrazhenskaia EA. Topical problems of occupational deafness. Meditsina truda i promyshlennaya ekologiya. 2007;12:34-39. (In Russ.)
  4. Melnick W. Industrial hearing conservation. In: Katz J, ed. Handbook of Clinical Audiology. Baltimore: The Willians & Wilkins; 1985.
  5. Borg E, Canlon B, Engstrom B. Noise-induced hearing loss. Literature review and experiments in rabbits. Morphological and electrophysiological features, exposure parameters and temporal factors, variability and interactions. Scandinavian Audiology, Supplement. 1995;24(40):1-147.
  6. Toppila E, Pyykkö I, Starck J. Age and noise-induced hearing loss. Scandinavian Audiology. 2001;30(4):236-244. https://doi.org/10.1080/01050390152704751
  7. Van Eyken E, Van Laer L, Fransen E, Topsakal V, Hendrickx JJ, Demeester K, Van de Heyning P, Maki-Torkko E, Hannula S, Sorri M, Jensen M, Parving A, Bille M, Baur M, Pfister M, Bonaconsa A, Mazzoli M, Orzan E, Espeso A, Stephens D, Verbruggen K, Huyghe J, Dhooge I, Huygen P, Kremer H, Cremers C, Kunst S, Manninen M, Pyykkö I, Rajkowska E, Pawelczyk M, Sliwinska-Kowalska M, Steffens M, Wienker T, Van Camp G. The contribution of GJB2 (Connexin 26) 35delG to age-related hearing impairment and noise-induced hearing loss. Otology and Neurotology. 2007;28(7):970-975. https://doi.org/10.197/MAO.0b013e3180dca1b9
  8. Li H-S. Influence of genotype and age on acute acoustic trauma and recovery in CBA/Ca and C57BL/6J mice. Acta Oto-Laryngologica. 1992;112(2):956-967. https://doi.org/10.3109/00016489209137496
  9. Davis RR, Newlander JK, Ling X-B, Cortopassi GA, Krieg EF, Erway LC. Genetic basis for susceptibility to noise-induced hearing loss in mice. Hearing Research. 2001;155(1-2):82-90. https://doi.org/10.1016/S0378-5955(01)00250-7
  10. Erway LC, Shiau YW, Davis RR, Krieg EF. Genetics of age-related hearing loss in mice. III. Susceptibility of inbred and F1 hybrid strains to noise-induced hearing loss. Hearing Research. 1996;93(1-2):181-187.
  11. Ohlemiller KK, McFadden SL, Ding DL, Flood DG, Reaume AG, Hoffman EK, Scott RW, Wright JS, Putcha GV, Salvi RJ. Targeted deletion of the cytosolic Cu/Zn-superoxide dismutase gene (Sod1) increases susceptibility to noise-induced hearing loss. Audiology Neurology. 1999;4(5):237-246. https://doi.org/10.1159/000013847
  12. Ohlemiller KK, McFadden SL, Ding DL, Lear PM, Ho YS. Targeted mutation of the gene for cellular glutathione peroxidase (Gpx1) increases noise-induced hearing loss in mice. Journal of the Association for Research in Otolaryngology. 2000;1(3):243-254. https://doi.org/10.1007/s101620010043
  13. Kozel PJ, Davis RR, Krieg EF, Shull GE, Erway LC. Deficiency in plasma membrane calcium ATPase isoform 2 increases susceptibility to noise-induced hearing loss in mice. Hearing Research. 2002;164(1-2):231-239. https://doi.org/10.1016/S0378-5955(01)00420-8
  14. Holme RH, Steel KP. Progressive hearing loss and increased susceptibility to noise-induced hearing loss in mice carrying a Cdh23 but not a Myo7a mutation. Journal of the Association for Research in Otolaryngology. 2004;5(1):66-79. https://doi.org/10.1007/s10162-003-4021-2
  15. Lavinsky J, Crow AL, Pan C, Wang J, Aaron KA, Ho MK, Li Q, Salehide P, Myint A, Monges-Hernadez M, Eskin E, Allayee H, Lusis AJ, Friedman RA. Genome-wide association study identifies nox3 as a critical gene for susceptibility to noise-induced hearing loss. PLoS Genetics. 2015;11(4):1005094. https://doi.org/10.1371/journal.pgen.1005094
  16. Yang S, Cai Q, Vethanayagam RR, Wang J, Yang W, Hu BH. Immune defense is the primary function associated with the differentially expressed genes in the cochlea following acoustic trauma. Hearing Research. 2016;333(1):283-294. https://doi.org/10.1016/j.heares.2015.10.010
  17. Cai Q, Vethanayagam RR, Yang S, Bard J, Jamison J, Cartwright D, Dong Y, Hu BH. Molecular profile of cochlear immunity in the resident cells of the organ of Corti. Jourmal of Neuroinflammation. 2014;11:173-194. https://doi.org/10.1186/s12974-014-0173-8
  18. Park J-S, Kang S-J, Seo M-K, Jou I, Woo HG, Park SM. Role of cysteinyl leukotriene signaling in a mouse model of noise-induced cochlear injury. Proceedings of the National Academy of Sciences of the United States of America. 2014;111(27):9911-9916. https://doi.org/10.1073/pnas.1402261111
  19. Yang S, Cai Q, Bard J, Jamison J,Wang J,Yang W, Hu BH. Variation analysis of transcriptome changes reveals cochlear genes and their associated functions in cochlear susceptibility to acoustic overstimulation. Hearing Research. 2015;330:78-89. https://doi.org/10.1016/j.heares.2015.04.010
  20. Sliwinska-Kowalska M, Pawelczyk. Contribution of genetic factors to noise-induced hearing loss: A human studies review. Mutation Research/Reviews in Mutation Research. 2013;752(1):61-65. https://doi.org/10.1016/j.mrrev.2012.11.001
  21. Grondin Y, Bortoni ME, Sepulveda R, Ghelfi E, Bartos A, Cotanche D, Clifford RE, Rogers RA. Genetic polymorphisms associated with hearing threshold shift in subjects during first encounter with occupational impulse noise. PLoS ONE. 2015;10(6):0130827. https://doi.org/10.1371/journal.pone.0130827
  22. Provenzano MJ, Domann FE. A role for epigenetics in hearing: Establishment and maintenance of auditory specific gene expression patterns. Hearing Research. 2007;233(1-2):1-13. https://doi.org/10.1016/j.heares.2007.07.002
  23. Brocchieri L, Conway de Macario E, Macario AJL. Hsp70 genes in the human genome: Conservation and differentiation patterns predict a wide array of overlapping and specialized functions. BMC Evolutionary Biology. 2008;8(1):19. https://doi.org/10.1186/1471-2148-8-19
  24. Ohlemiller KK. Recent findings and emerging questions in cochlear noise injury. Hearing Research. 2008;245(1-2):5-17. https://doi.org/10.1016/j.heares.2008.08.007
  25. Op de Beeck K, Schacht J, Van Camp G. Apoptosis in acquired and genetic hearing impairment: The programmed death of the hair cell. Hearing Research. 2011;281(1-2):18-27. https://doi.org/10.1016/j.heares.2011.07.002
  26. Böttger EC, Schacht J. The mitochondrion: a perpetrator of acquired hearing loss. Hearing Research. 2013;303:12-19. https://doi.org/10.1016/j.heares.2013.01.006
  27. Henderson D, Bielefeld EC, Harris KC, Hu BH. The role of oxidative stress in noise-induced hearing loss. Ear and Hearing. 2006;27(1):1-19. https://doi.org/10.1097/01.aud.0000191942.36672.f3
  28. Rabinowitz PM, Pierce Wise Sr J, Hur Mobo B, Antonucci PG, Powell C, Slade M Antioxidant status and hearing function in noise-exposed workers. Hearing Research. 2002;173(1-2):164-171. https://doi.org/10.1016/S0378-5955(02)00350-7
  29. Yang M, Tan H, Zheng JR, Jiang CZ. Relationship between GSTM1 and GSTT1 gene polymorphisms and noise induced hearing loss in Chinese workers. Journal of hygiene research. 2005;34(6):647-649.
  30. Carlsson P-I, Van Laer L, Borg E, Bondeson M-L, Thys M, Fransen E, Van Camp G. The influence of genetic variation in oxidative stress genes on human noise susceptibility. Hearing Research. 2005;202(1-2):87-96. https://doi.org/10.1016/j.heares.2004.09.005
  31. Carlsson PI, Fransen E, Stenberg E, Bondeson ML. The influence of genetic factors, smoking and cardiovascular diseases on human noise susceptibility. Audiological Medicine. 2007;5(2):82-91. https://doi.org/10.1080/16513860701194683
  32. Fortunato G, Marciano E, Zarrilli F, Mazzaccara C, Intrieri M, Calcagno G, Vitale DF, La Manna P, Saulino C, Marcelli V, Sacchetti L. Paraoxonase and superoxide dismutase gene polymorphisms and noise-induced hearing loss. Clinical Chemistry. 2004;50(11):2012-2018. https://doi.org/10.1373/clinchem.2004.037788
  33. Li X, Cao J, Wang J, Song H, Ji G, Dong Q, Wei C, Cao Y, Wang B, Zhu B, Xiao H. PON2 and ATP2B2 gene polymorphisms with noise-induced hearing loss. Journal of Thoracic Disease. 2016;8(3):430-438. https://doi.org/10.21037/jtd.2016.02.26
  34. Liu YM, Li XD, Guo X, Liu B, Lin AH, Ding YL, Rao SQ. SOD2 V16A SNP in the mitochondrial targeting sequence is associated with noise induced hearing loss in Chinese workers. Disease Markers. 2010;28(3):137-147. https://doi.org/10.3233/DMA-2010-0693
  35. Liu YM, Li XD, Guo X, Liu B, Lin AH, Rao SQ. Association between polymorphisms in SOD1 and noise-induced hearing loss in Chinese workers. Acta Oto-Laryngologica. 2010;130(4):477-486. https://doi.org/10.3109/00016480903253587
  36. Konings A, Van Laer L, Pawelczyk M, Carlsson P-I, Bondeson M-L, Rajkowska E, Dudarewicz A, Vandevelde A, Fransen E, Huyghe J, Borg E, Sliwinska-Kowalska M, Van Camp G. Association between variations in CAT and noise-induced hearing loss in two independent noise-exposed populations. Human Molecular Genetics. 2007;16(15):1872-1883. https://doi.org/10.1093/hmg/ddm135
  37. Wang SL, Yu LG, Liu RP, Zhu WZ, Gao WM, Xue LP, Jiang X, Zhang, YH, Yi D, Chen D, Zhang YH. Gene-gene interaction of GJB2, SOD2, and CAT on occupational noise-induced hearing loss in Chinese han population. Biomedical and Environmental Sciences. 2014;27(12):965-968. https://doi.org/10.3967/bes2014.131
  38. Zheng G, Hu BH. Cell-cell junctions: a target of acoustic overstimulation in the sensory epithelium of the cochlea. BMC Neuroscience. 2012;13(1):71. https://doi.org/10.1186/1471-2202-13-71
  39. Van Laer L, Carlsson P-I, Ottschytsch N, Bondeson M-L, Konings A, Vandevelde A, Dieltjens N, Fransen E, Snyders D, Borg E, Raes A, Van Camp G. The contribution of genes involved in potassium-recycling in the inner ear to noise-induced hearing loss. Human Mutation. 2006;27(8):786-795. https://doi.org/10.1002/humu.20360
  40. Pawelczyk M, Van Laer L, Fransen E, Rajkowska E, Konings A, CarlssonP-I, Borg E, Van Camp G, Sliwinska-Kowalska M. Analysis of gene polymorphisms associated with K+ ion circulation in the inner ear of patients susceptible and resistant to noise-induced hearing loss. Annals of Human Genetics. 2009;73(4):411-421. https://doi.org/10.1111/j.1469-1809.2009.00521.x
  41. Carlsson P-I, Borg E, Grip L, Dahl N, Bondeson M-L. Variability in noise susceptibility in a Swedish population: The role of 35delG mutation in the connexin 26 (GJB2) gene. Audiological Medicine. 2004;2(2):123-130. https://doi.org/10.1080/16513860410035854
  42. Abreu-Silva RS, Rincon D, Horimoto AR, Squillar AP, Ricardo LA, Kimura L, Batissoco AC, Auricchio MT, Otto PA, Mingroni-Netto RC. The seach of genetic basis for nois-induced hearing loss (NIHL). Annals of Human Biology. 2011;38(2):210-218. https://doi.org/10.3109/03014460.2010.513774
  43. Sakaguchi H, Tokita J, Müller U, Kachar B. Tip links in hair cells: molecular composition and role in hearing loss. Current Opinion in Otolaryngology and Head and Neck Surgery. 2009;17(5):388-393. https://doi.org/10.1097/MOO.0b013e3283303472
  44. Yang M, Tan H, Zheng JR, Wang F, Jiang C, He M, ChenY, Wu T. Association of cadherin CDH23 gene polymorphisms with noise induced hearing loss in Chinese workers. Journal of hygiene research. 2006;35(1):19-22. (In Chinese).
  45. Kowalski TJ, Pawelczyk M, Rajkowska E, Dudarewicz A, Sliwinska-Kowalska M. Genetic variants of CDH23 associated with noise-induced hearing loss. Otology and Neurotology. 2014; 35(2):358-365. https://doi.org/10.1097/MAO.0b013e3182a00332
  46. Konings A, Van Laer L, Wiktorek-Smagur A, Rajkowska E, Pawelczyk M, Carlsson PI, Bondeson ML, Dudarewicz A, Vandevelde A, Fransen E, Huyghe J, Borg E, Sliwinska-Kowalska M, Van Camp G. Candidate gene association study for noise-induced hearing loss in two independent noise-exposed populations. Annals of Human Genetics. 2009;73(2):215-224. https://doi.org/10.1111/j.1469-1809.2008.00499.x
  47. Zhang X, Liu Y, Zhang L, Yang Z, Shao Y, Jiang C, Wang Q, Fang X, Xu Y, Wang H, Zhang S, Zhu Y. Genetic variations in protocadherin 15 and their interactions with noise exposure associated with noise-induced hearing loss in Chinese population. Environmental Research. 2014;135:247-252. https://doi.org/10.1016/j.envres.2014.09.021
  48. Lim HH, Jenkins OH, Myers MW, Miller JM, Altschuler RA. Detection of HSP 72 synthesis after acoustic overstimulation in rat cochlea. Hearing Research. 1993;69(1-2):146-150. https://doi.org/10.1016/0378-5955(93)90102-7
  49. Yoshida N, Kristiansen A, Liberman MC. Heat stress and protection from permanent acoustic injury in mice. Journal of Neuroscience. 1999;19(22):10116-10124.
  50. Wang XW, Wang XJ, Song JS, Chen HX, Man YH. Influence of evoked HSP70 expression on hearing function of the cochlea in guinea pigs. Academic journal of the first medical college of PLA. 2002;22(10):922-924.
  51. Altschuler RA, Fairfield D, Cho Y, Leonova E, Benjamin IJ, Miller JM, Lomax MI. Stress pathways in the rat cochlea and potential for protection from acquired deafness. Audiology and Neuro-Otology. 2002;7(3):152-156. https://doi.org/10.1159/000058301
  52. Konings A, Van Laer L, Michel S, Pawelczyk M, Carlsson P-I, Bondeson M-L, Rajkowska E, Dudarewicz A, Vandevelde A, Fransen E, Huyghe J, Borg E, Sliwinska-Kowalska M, Van Camp G. Variations in HSP70 genes associated with noise-induced hearing loss in two independent populations. European Journal of Human Genetics. 2009;17(3):329-335. https://doi.org/ 10.1038/ejhg.2008.172
  53. Zhang X, Liu Y, Zhang L, Yang Z, Yang L, Wang X, Jiang C, Wang Q, Xia Y, Chen Y, Wu O, Zhu Y. Associations of genetic variations in EYA4, GRHL2 and DFNA5 with noise-induced hearing loss in Chinese population: a case- control study. Environmental Health: A Global Access Science Source. 2015;14(1):77. https://doi.org/10.1186/s12940-015-0063-2
  54. Henderson D, Bielefeld EC, Harris KC, Hu BH. The role of oxidative stress in noise-induced hearing loss. Ear and Hearing. 2006; 27(1):1-19. https://doi.org/10.1097/01.aud.0000191942.36672.f3
  55. Shen H, Cao J, Hong Z, Liu K, Shi J, Ding L, Zhang H, Du C, Li Q, Zhang Z, Zhu B. A functional Ser326Cys polymorphism in hOGG1 is associated with noise-induced hearing loss in a Chinese population. PLoS One. 2014;9(3):89662. https://doi.org/10.1371/journal.pone.0089662
  56. Shen H, Dou J, Han L, Bai Y, Li Q, Hong Z, Shi J, Zhang H, Zhang F, Du C, Tong Z, Zhu B. Genetic variation in APE1 gene promoter is associated with noise-induced hearing loss in a Chinese population. International Archives of Occupational and Environmental Health. 2016;89(4):621-628. https://doi.org/10.1007/s00420-015-1100-8
  57. Strachan T, Read A. Human Molecular Genetics. New York: Garland Science Taylor and Francis Group; 2011.
  58. Clifford RE, Hoffer M, Rogers R. The Genomic Basis of Noise-induced Hearing Loss: A Literature Review Organized by Cellular Pathways. Otology and Neurotology. 2016;37(8):309-316. https://doi.org/10.1097/MAO.0000000000001073

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