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Krasitskaya V.V.

Krasnoyarsk Research Centre of the Siberian Division of the Russian Academy of Sciences, Krasnoyarsk, Russia, 660036

Bashmakova E.E.

Krasnoyarsk Research Centre of the Siberian Division of the Russian Academy of Sciences, Krasnoyarsk, Russia, 660036

Dobretsov K.G.

Tsentr otorinolaringologii Sibirskogo klinicheskogo tsentra Rossii, Krasnoiarsk

Orlova N.V.

The Centre for Otorhinolaryngology, Federal Siberian Research and Clinical Centre, Federal Medico-Biological Agency, Krasnoyarsk, Russia, 660037

Frank L.A.

Krasnoyarsk Research Centre of the Siberian Division of the Russian Academy of Sciences, Krasnoyarsk, Russia, 660036

The genetic aspects of occupational hearing impairment

Authors:

Krasitskaya V.V., Bashmakova E.E., Dobretsov K.G., Orlova N.V., Frank L.A.

More about the authors

Journal: Russian Bulletin of Otorhinolaryngology. 2017;82(5): 71‑76

DOI: 10.17116/otorino201782571-76

Read: 1777 times

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Table of contents

THE GENETIC ASPECTS OF OCCUPATIONAL HEARING IMPAIRMENT
THE GENETIC ASPECTS OF OCCUPATIONAL HEARING IMPAIRMENT

To cite this article:

Krasitskaya VV, Bashmakova EE, Dobretsov KG, Orlova NV, Frank LA. The genetic aspects of occupational hearing impairment. Russian Bulletin of Otorhinolaryngology. 2017;82(5):71‑76. (In Russ.)
https://doi.org/10.17116/otorino201782571-76

Подписка 2026 Вестник оториноларингологии (Russian Bulletin of Otorhinolaryngology)
МСФ на ЯМ
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Abstract:

This article was designed to be the overview of the current literature publications concerning the identification of the genetic markers of susceptibility to the noise-induced loss of hearing. The analysis of these data has demonstrated that the major gene polymorphisms associated with the development of this pathological condition are localized in the genes encoding for the antioxidant systems, potassium homeostasis, and adhesion molecules as well as in the genes involved in intercellular coupling, the mechanisms underlying the cellular response to stress, activation and regulation of heat shock proteins, and signaling function of the immune system. It is concluded that the further investigations into the genetic aspects of the full-genome sequencing techniques and the search for genomic associations could greatly contribute to the development of personalized medicine and the reduction of risks of occupational noise-induced sensorineural impairment of hearing.

Keywords:

noise-induced impairment of hearing
association studies
single-nucleotide polymorphisms
metabolic pathways

Authors:

Krasitskaya V.V.

Krasnoyarsk Research Centre of the Siberian Division of the Russian Academy of Sciences, Krasnoyarsk, Russia, 660036

Bashmakova E.E.

Krasnoyarsk Research Centre of the Siberian Division of the Russian Academy of Sciences, Krasnoyarsk, Russia, 660036

Dobretsov K.G.

Tsentr otorinolaringologii Sibirskogo klinicheskogo tsentra Rossii, Krasnoiarsk

Orlova N.V.

The Centre for Otorhinolaryngology, Federal Siberian Research and Clinical Centre, Federal Medico-Biological Agency, Krasnoyarsk, Russia, 660037

Frank L.A.

Krasnoyarsk Research Centre of the Siberian Division of the Russian Academy of Sciences, Krasnoyarsk, Russia, 660036

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