The objective of the present controlled randomized study was to estimate the clinical effectiveness of the antiseptic treatment of the operative field for endoscopic adenotomy. It is based on the results of the examination and treatment of 202 children at the age varying from 4 to 10 years admitted with the diagnosis of adenoids for the planned surgical intervention between 2010 and 2012. The results of the study indicate that postoperative objective and subjective symptoms of the disease were significantly less pronounced in the case of the preoperative treatment of the operative field than without it. Specifically, statistically significant reduction in the severity of postoperative reactive inflammation was documented. Double antiseptic washing of the nasopharynx caused neither complications nor undesirable adverse reactions and significantly reduced the requirements for systemic antibacterial preparations and anesthetics. It is concluded that the preoperative antiseptic treatment of the operative field for endoscopic adenotomy is a safe and effective procedure that can be recommended for a wider clinical application.