The objective of the present study was to estimate the diagnostic value of the characteristics of somatic pathology included in the algorithm for early diagnostics of occupational sensorineural impairment of hearing (OSNIH). The relationship between the development of the main nosological forms of somatic pathology as possible markers of internal ear diseases and professional sensorineural impairment of hearing was elucidated among the members of locomotive crews (n=224). The parameters of interest were evaluated 4 years before, within 1 year, and 4 years after the establishment of diagnosis of OSNIH. It was shown that the members of locomotive crews most frequently suffer atherosclerosis (20.0%), gastrointestinal disorders (34.8%), arterial hypertension (25.0%), osteochondrosis (largely vertebrogenic lumbodynia (21.3%)), and microcirculatory disturbances in the form of vascular spasm in the fundus of the eye (32.9%). 97.6% of the subjects above 35 years of age presented with hypercholesterolemia. Comparative analysis of the occurrence of these nosological forms among the members of locomotive crews with hearing problems on the one hand and the normally functioning organ of hearing on the other hand has demonstrated that none of these pathologies can be regarded as a marker for early diagnosis of OSNIH. At the same time, overweight even in the subjects under 35 years of age should be taken into account when planning and implementing preventive measures.