The objective of the present study was to estimate the prevalence of chronic pathology of ENT organs and mucous membrane of the oral cavity in the HIV-infected patients depending on the number of cells containing CD4 markers in 1 mcl of blood plasma. It was shown that the prevalence of chronic pathology of ENT organs and oral mucosa in the HIV-infected patients depends on the number of cells carrying CD4 markers in 1 mcl of blood plasma. This pathology was found in 64.6% of the patients at immunological stage I of infection with human immunodeficiency virus (over 500 CD4 per 1 mcl plasma), in 73.4% of the patients at stage II of HIV infection (200-499 CD4/1 mcl), and in 90.7% of the patients at stage III of HIV infection (less than 200 CD4/1 mcl). The frequency of individual nosological forms of ENT disease at different stages of infection with human immunodeficiency virus is discussed. Certain diseases pathognomonic for HIV-infected adult subjects were identified including adenoid vegetations, cheilitis, oral hairy leukoplakia, and oropharyngeal candidiasis. Combined chronic pathology of ENT organs as well as certain clinical features of the above diseases may suggest diagnosis of immunodeficiency and require the assessment for the HIV status.