Recurrent herpetic erosion of the cornea: diagnosis, treatment and prevention of recurrences

Kasparova Evg.A.

Krasnov Research Institute of Eye Diseases;
OOO Moscow Research Ophthalmological Center “Noviy Vzglyad”

ORCID: 0000-0001-8594-2395

Kasparova E.A.

OOO Moscow Research Ophthalmological Center “Noviy Vzglyad”

ORCID: 0000-0003-3372-7989

Marchenko N.R.

Krasnov Research Institute of Eye Diseases

ORCID: 0000-0001-6945-237X

Kasparov A.A.

Krasnov Research Institute of Eye Diseases;
OOO Moscow Research Ophthalmological Center “Noviy Vzglyad”

Recurrent herpetic erosion of the cornea: diagnosis, treatment and prevention of recurrences

Authors:

Kasparova Evg.A., Kasparova E.A., Marchenko N.R., Kasparov A.A.

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Journal: Russian Annals of Ophthalmology. 2024;140(2‑2): 102‑108

DOI: 10.17116/oftalma2024140022102

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To cite this article:

Kasparova EvgA, Kasparova EA, Marchenko NR, Kasparov AA. Recurrent herpetic erosion of the cornea: diagnosis, treatment and prevention of recurrences. Russian Annals of Ophthalmology. 2024;140(2‑2):102‑108. (In Russ.)
https://doi.org/10.17116/oftalma2024140022102

Подписка 2025 (Russian Annals of Ophthalmology)

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A group of patients was found to have a special form of recurrent corneal erosion caused by types I and II herpes virus. This form represents an independent form of ophthalmic herpes — herpetic recurrent erosion (HRE) of the cornea. The herpetic etiology of recurrent corneal erosion was confirmed by the immunofluorescence study of scraping from the conjunctiva, which revealed a high concentration of the herpes simplex virus antigen. Treatment of patients (171 patients, 182 eyes) with HRE included 2 consecutive stages: stage I — relief of acute symptoms of the disease with the help of conservative treatment (instillations of interferon inducers, autologous serum, corneal protectors, tear substitutes, use of therapeutic soft contact lenses); in some cases, phototherapeutic keratectomy was used in the absence of the effect of conservative therapy, as well as in the localization of the focus in the optical zone. Stage II involved anti-relapse therapy based on the use of a Russian-produced herpes vaccine in the intercurrent period. After vaccination, observation for 2 years or more showed that 81.3% of patients achieved clinical recovery (complete cessation of HRE recurrences), 15.8% had a decrease in the frequency and severity of relapses, while 2.9% of patients did not respond to the treatment.

Keywords:

herpetic eye diseases

recurrent corneal erosion

herpetic recurrent corneal erosion

corneal epithelium

herpes simplex virus

fluorescent antibody method

interferon inducer

autologous serum

herpes vaccine

herpetic eye diseases

recurrent corneal erosion

herpetic recurrent corneal erosion

corneal epithelium

herpes simplex virus

fluorescent antibody method

interferon inducer

autologous serum

herpes vaccine

Authors:

Kasparova Evg.A.

Krasnov Research Institute of Eye Diseases;
OOO Moscow Research Ophthalmological Center “Noviy Vzglyad”

ORCID: 0000-0001-8594-2395

Kasparova E.A.

OOO Moscow Research Ophthalmological Center “Noviy Vzglyad”

ORCID: 0000-0003-3372-7989

Marchenko N.R.

Krasnov Research Institute of Eye Diseases

ORCID: 0000-0001-6945-237X

Kasparov A.A.

Krasnov Research Institute of Eye Diseases;
OOO Moscow Research Ophthalmological Center “Noviy Vzglyad”

Received:

28.04.2023

Accepted:

04.08.2023

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