Venous blood flow in ocular vessels of patients with active retinopathy of prematurity

Trifanenkova I.G.; Tereshchenko A.V.; Erokhina E.V.

doi:https://doi.org/10.17116/oftalma202113704165

Trifanenkova I.G.

Kaluga branch of S.N. Fyodorov National Medical Research Center «MNTK «Eye Microsurgery»

Tereshchenko A.V.

Kaluga branch of S.N. Fyodorov National Medical Research Center «MNTK «Eye Microsurgery»

Erokhina E.V.

Kaluga Branch of the S.N. Fedorov National Medical Research Center «MNTK «Eye Microsurgery»

Venous blood flow in ocular vessels of patients with active retinopathy of prematurity

Authors:

Trifanenkova I.G., Tereshchenko A.V., Erokhina E.V.

More about the authors

Journal: Russian Annals of Ophthalmology. 2021;137(4): 65‑71

DOI: 10.17116/oftalma202113704165

Read: 1459 times

Download PDF (RU)

Contact the author

Table of contents

To cite this article:

Trifanenkova IG, Tereshchenko AV, Erokhina EV. Venous blood flow in ocular vessels of patients with active retinopathy of prematurity. Russian Annals of Ophthalmology. 2021;137(4):65‑71. (In Russ.)
https://doi.org/10.17116/oftalma202113704165

Подписка 2026 Вестник офтальмологии (Russian Annals of Ophthalmology)

Использование инфографики авторами научных работ

Close metadata

Abstract:

PURPOSE

To study the characteristics of venous circulation in the eyes with retinopathy of prematurity (ROP) observed in examination of blood flow in the central retinal vein and superior orbital vein in patients with different forms, stages and state of the disease.

MATERIAL AND METHODS

Color duplex scanning of the central retinal vein and superior orbital vein was performed using color Doppler imaging and pulsed Doppler sonography in 55 premature babies (55 eyes) with active ROP and 8 premature babies (8 eyes) with no signs of ROP. All babies included in the study were born at 25—32 weeks of gestation, their birth weight was 680—1760 g.

RESULTS

A characteristic feature of hemodynamic parameters in the central retinal vein at stages 1—3 of active ROP was a decrease in both the maximum and minimum blood flow velocities (V_max and V_min), indicating a serious disorder of ocular hemodynamics in this category of patients. An increase in V_max in the central retinal vein was recorded for patients with aggressive posterior ROP, which occurs in response to venous stasis that is common in this form of the disease. The performed statistical assessment of the prognostic significance of hemodynamic parameters of the central retinal vein in relation to the type of active ROP revealed a high information content of V_min, which is promising for early detection of unfavorable course of the disease helping to ensure timely treatment. The blood flow in the superior orbital vein showed distinctive absence of any correlations with the course of the disease, disallowing any immediate conclusions on the informativeness and predictive value of its parameters.

CONCLUSION

The revealed features of venous blood flow in patients with active ROP help expand the understanding of vascular changes in this pathology, and can also be applied in clinical practice to improve the accuracy of predicting the course of the disease.

Keywords:

retinopathy of prematurity

venous blood flow

central retinal vein

superior orbital vein

Authors:

Trifanenkova I.G.

Kaluga branch of S.N. Fyodorov National Medical Research Center «MNTK «Eye Microsurgery»

Tereshchenko A.V.

Kaluga branch of S.N. Fyodorov National Medical Research Center «MNTK «Eye Microsurgery»

Erokhina E.V.

Kaluga Branch of the S.N. Fedorov National Medical Research Center «MNTK «Eye Microsurgery»

Received:

16.02.2021

Accepted:

14.05.2021

Close metadata

References:

Sidorenko EI. Ophthalmopathy (retinopathy) of prematurity — a problem for all over life. Tavricheskij mediko-biologicheskij vestnik. 2015;18(1):117-119. (In Russ.). https://cyberleninka.ru/article/n/oftalmopatiya-retinopatiya-nedonoshennyh-problema-na-vsyu-zhizn/viewer
Sidorenko EI, Astasheva IB. Retinopathy of prematurity as a problem of modern ophthalmology. Rossijskaya pediatricheskaya oftal’mologiya. 2007;(4): 4-10. (In Russ.).
Tereshhenko AV, Belyj YuA, Isaev SV, Trifanenkova IG, Yudina YuA. Morphometric study of the state of the retinal vessels in the early stages of retinopathy of prematurity. Oftal’mologiya. 2013;10(3):10-14. (In Russ.). https://doi.org/10.18008/1816-5095-2013-3-33-39
Tereshhenko AV, Belyj YuA, Isaev SV, Trifanenkova IG. Retinal vessels condition in retinopathy of prematurity. Vestnik oftal’mologii. 2014;130(3):26-31. (In Russ.). https://www.mediasphera.ru/issues/vestnik-oftalmologii/2014/3/downloads/ru/030042-465X201436
Wilson C, Wong K, Ng J, Cocker K, Ells K, Fielder A. Digital image analysis in retinopathy of prematurity: a comparison of vessel selection methods. J AAPOS. 2012;16(3):223-228. https://doi.org/10.1016/j.jaapos.2011.11.015
Vickers LA, Freedman SF, Wallace DK, Prakalapakorn SG. ROPtool analysis of images acquired using a noncontact handheld fundus camera (Pictor) — a pilot study. J AAPOS. 2015;19(6);570-572. https://doi.org/10.1016/j.jaapos.2015.07.291
Tereshhenko AV, Trifanenkova IG, Belyj YuA, Isaev SV, Panamareva SV. Morphometric analysis of retinal vessels in the active stages of classic retinopathy of prematurity. Vestnik Orenburgskogo gosudarstvennogo universiteta. 2013;(4):253-257. (In Russ.). https://cyberleninka.ru/article/n/morfometricheskiy-analiz-sosudov-setchatki-pri-klassicheskom-techenii-aktivnyh-stadiy-retinopatii-nedonoshennyh/viewer
Ozcan P, Dogan F, Sonmez K, Con R, Dokumaci D, Seyhanli E. Assessment of orbital blood flow velocities in retinopathy of prematurity. Int Ophthalmol. 2017;37(4):795-799. https://doi.org/10.1007/s10792-016-0333-1
Hartenstein S, Müller B, Metze B, Czernik C, Bührer C. Blood flow assessed by color Doppler imaging in retinopathy of prematurity. J Perinatol. 2015; 35(9):745-747. https://doi.org/10.1038/jp.2015.45
Neely D, Harris A, Hynes E, McNulty L, McCranor L, Siesky B, Plager D, Sprunger D, Roberts G. Longitudinal assessment of plus disease in retinopathy of prematurity using color Doppler imaging. J AAPOS. 2009;13(5):509-511. https://doi.org/10.1016/j.jaapos.2009.08.012.
Soares C, Silveira R, Procianoy R. Ophthalmic artery blood flow in very-low-birth-weight preterm infants. Invest Ophthalmol Vis Sci. 2010;51(2):708-711. https://doi.org/10.1167/iovs.09-4206.
Niwald A, Grałek M. Evaluation of blood flow in the ophthalmic artery and central retinal artery in children with retinopathy of prematurity. Klin Oczna. 2006;108(1-3):32-35.
Harris A, Garzozi H, Harris-Izhak M, Shoham N, Holland D. Color Doppler imaging of central retinal artery in retinopathy of prematurity. Harefuah. 2000;138(10):812-815, 912.
Kiseleva TN. Color duplex scanning in the diagnosis of eye and orbit diseases. In: Ul’trazvukovye issledovaniya v oftal’mologii. Rukovodstvo dlya vrachej [Ultrasound examinations in ophthalmology. A guide for doctors]. M. 2019. (In Russ.).
Kiseleva TN, Zaitsev MS, Ramazanova KA, Lugovkina KV. Possibilities of color duplex scanning in the diagnosis of eye vascular pathology. Rossijskij oftal’mologicheskij zhurnal. 2014;130(3):26-31. (In Russ.). https://doi.org/10.21516/2072-0076-2018-11-3-84-94
Kurysheva NI, Maslova EV, Trubilina AV, Fomin AV. OCT-angiography and color Doppler mapping in the study of retinal and optic nerve hemoperfusion in glaucoma. Oftal’mologiya. 2016;13(2):102-110. (In Russ.). https://doi.org/10.18008/1816-5095-2016-2-102-110
Kurysheva NI, Parshunina OA, Maslova EV, Shatalova EO, Kiseleva TN, Lagutin MB. Diagnostic significance of ocular blood flow research in early detection of primary open-angle glaucoma. Nacional’nyj zhurnal glaukoma. 2015;14(3):19-29. (In Russ.). https://www.glaucomajournal.ru/jour/article/view/70
Kurysheva NI, Kiseleva TN, Irtegova EYu. Features of venous blood flow of the eye in primary open-angle glaucoma. Glaukoma. ZHurnal NII GB RAMN. 2012;(4):24-30. (In Russ.). https://elibrary.ru/item.asp?id=21063911
Kurysheva NI, Apostolova AS, Arjevnishvili TD, Kiseleva TN, Fomin AV. Investigation of morphological changes and regional hemodynamics in pseudoexfoliative glaucoma. Oftal’mologiya. 2014;11(1):38-44. (In Russ.). https://doi.org/10.18008/1816-5095-2014-1-38-44
Nikolaeva GV. Detection of myogenic autoregulation of blood flow in the anterior cerebral and ocular arteries in premature infants. Rossijskaya detskaya oftal’mologiya. 2014;(4):15-21. (In Russ.). https://eyepress.ru/article.aspx?15676
Tereshhenko AV, Belyj YuA, Trifanenkova I., Tereshhenkova M. Working classification of early stages of retinopathy of prematurity. Oftal’mokhirurgiya. 2008;(1):32-34. (In Russ.). https://elibrary.ru/item.asp?id=15533675
Kat’kova EA. Diagnosticheskij ul’trazvuk. Oftal’mologiya [Diagnostic ultrasound. Ophthalmology]. 1st ed. Pod red. Zubarev A.V., ed. M. 2002. (In Russ.).
Trifanenkova IG, Tereshhenko AV. The study the possibilities of color duplex scanning in assessing the state of ocular blood flow in patients with active ROP. Saratovskij nauchno-meditsinskij zhurnal. 2020;16(1):303-308. (In Russ.). https://ssmj.ru/system/files/2020_01-2_303-308.pdf
Kulikov VP, Mogozov AV, Graf EV. Power Doppler ultrasonography in the diagnosis of pathological tortuosity of brachiocephalic arteries. Vizualizatsiya v klinike. 1995;(12):13-16. (In Russ.).