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Guliaev S.V.

Klinika nefrologii, vnutrennikh i professional'nykh zabolevaniĭ, Universitetskaia klinicheskaia bol'nitsa #3 Pervogo MGMU im. I.M. Sechenova, Moskva

Strizhakov L.A.

Klinika nefrologii, vnutrennikh i professional'nykh zabolevaniĭ, Universitetskaia klinicheskaia bol'nitsa #3 Pervogo MGMU im. I.M. Sechenova, Moskva

Novikov P.I.

UCH №3 of I.M. Sechenov First Moscow State Medical University, 11, str.5 Rossolimo St., Moscow, Russian Federation, 119021

Mukhin N.A.

GBOU VPO «Pervyj Moskovskij gosudarstvennyj meditsinskij universitet im. I.M. Sechenova», Moskva

Fomin V.V.

I.M. Sechenov First State Moscow Medical University

Giant cell arteritis: Genetic and epigenetic aspects

Authors:

Guliaev S.V., Strizhakov L.A., Novikov P.I., Mukhin N.A., Fomin V.V.

More about the authors

Journal: Therapeutic Archive. 2017;89(8): 72‑76

Read: 2369 times


To cite this article:

Guliaev SV, Strizhakov LA, Novikov PI, Mukhin NA, Fomin VV. Giant cell arteritis: Genetic and epigenetic aspects. Therapeutic Archive. 2017;89(8):72‑76. (In Russ.)
https://doi.org/10.17116/terarkh201789872-76

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References:

  1. Jennette JC, Falk RJ, Bacon PA, Basu N, Cid MC, Ferrario F, Flores-Suarez LF, Gross WL, Guillevin L, Hagen EC, Hoffman GS, Jayne DR, Kallenberg CGM, Lamprecht P, Langford CA, Luqmani RA, Mahr AD, Matteson EL, Merkel PA, Ozen S, Pusey CD, Rasmussen N, Rees AJ, Scott DGI, Specks U, Stone JH, Takahashi K, Watts RA. 2012 Revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides. Arthritis Rheum. 2013;65:1-11. https://doi.org/10.1002/art.37715
  2. Hutchinson J. Diseases of the arteries. I. On a peculiar form of thrombotic arteritis of the aged which is sometimes productive of gangrene. Arch Surg (Lond). 1890;1:323-329.
  3. Horton BT, Magath T, Brown GE. An undescribed form of arteritis of the temporal vessels. Mayo Clin Proc. 1932;7:700-701.
  4. Schmidt J1, Warrington KJ. Polymyalgia rheumatica and giant cell arteritis in older patients: diagnosis and pharmacological management. Drugs Aging. 2011;1;28(8):651-666. https://doi.org/10.2165/11592500-000000000-00000
  5. Richard A Watts, David GI Scott. Epidemiology of vasculitis in Oxford Textbook of Vasculitis, edited by Gene V Ball, Barri J Fessler, S Louis Bridges. Oxford University Press 2014, third edition. https://doi.org/0.1093/med/ 9780199659869.001.0001
  6. Liozon E, Ouattara B, Rhaiem K, Ly K, Bezanahary H, Loustaud V, Letellier P, Drouet M, Vidal E. Familial aggregation in giant cell arteritis and polymyalgia rheumatica: a comprehensive literature review including 4 new families. Clin Exp Rheumatol. 2009;27: S89-94.
  7. Fietta P, Manganelli P, Zanetti A, Neri TM. Familial giant cell arteritis and polymyalgia rheumatica: aggregation in 2 families. J Rheumatol. 2002;29:1551-1555.
  8. Liang GC, Simkin PA, Hunder GG, Wilske KR, Healey LA. Familial aggregation of polymyalgia rheumatica and giant cell arteritis. Arthritis Rheum. 1974;17(1):19-24.
  9. Granato JE, Abben RP, May WS. Familial association of giant cell arteritis. A case report and brief review. Arch Intern Med. 1981;141:115-117.
  10. Mathewson JA, Hunder GG. Giant cell arteritis in two brothers. J Rheumatol. 1986;13:190-192.
  11. Wernick R, Davey M, Bonafede P. Familial giant cell arteritis: report of an HLA-typed sibling pair and a review of the literature. Clin Exp Rheumatol. 1994;12:63-66.
  12. Gros F, Maillefert JF, Behin A, Guignier F. Giant cell arteritis with ocular complications discovered simultaneously in two sisters. Clin Rheumatol. 1998;17:58-61.
  13. Raptis L, Pappas G, Akritidis N. Horton’s three sisters: familial clustering of temporal arteritis. Clin Rheumatol. 2007;26:1997-1998.
  14. Hunder GG, Bloch DA, Michel BA, Stevens MB, Arend WP, Calabrese LH, Edworthy SM, Fauci AS, Leavitt RY, Lie JT. The American College of Rheumatology 1990 criteria for the classification of giant cell arteritis, et al. Arthritis Rheum. 1990;33(8):1122-1128.
  15. Gulyaev SV, Meshkov AD, Novikov PI, Moiseev SV, Fomin VV. Giant cell arteritis as a cause of fever of unclear genesis in the elderly. Therapeutic archive. 2014;12(2):47-51. (In Russ.).
  16. Carmona FD, González-Gay MA, Martín J. Genetic component of giant cell arteritis. Rheumatology (Oxford). 2014;53(1):6-18. https://doi.org/10.1093/rheumatology/ket231
  17. González-Gay MA, García-Porrúa C, Llorca J, Hajeer AH, Brañas F, Dababneh A, González-Louzao C, Rodriguez-Gil E, Rodríguez-Ledo P, Ollier WE. Visual manifestations of giant cell arteritis. Trends and clinical spectrum in161 patients. Medicine. 2000;79:283-292.
  18. Rauzy O, Fort M, Nourhashemi F, Alric L, Juchet H, Ecoiffier M, Abbal M, Adoue D. Relation between HLA DRB1 alleles and corticosteroid resistance in giant cell arteritis. Ann Rheum Dis. 1998;57:380-382.
  19. Weyand CM, Ma-Krupa W, Pryshchep O, Gröschel S, Bernardino R, Goronzy JJ. Vascular dendritic cells in giant cell arteritis. Ann NY Acad Sci. 2005;1062:195-208.
  20. Palomino-Morales R, Torres O, Vazquez-Rodriguez TR, Morado IC, Castañeda S, Callejas-Rubio JL, Miranda-Filloy JA, Fernandez-Gutierrez B, Martin J, Gonzalez-Gay MA. Association between toll-like receptor 4 gene polymorphism and biopsy-proven giant cell arteritis. J Rheumatol. 2009;36:1501-1506.
  21. Song GG1, Choi SJ, Ji JD, Lee YH. Toll-like receptor polymorphisms and vasculitis susceptibility: meta-analysis and systematic review. Mol Biol Rep. 2013;40(2):1315-1323.
  22. Serrano A, Carmona FD, Castañeda S, Solans R, Hernández-Rodríguez J, Cid MC, Prieto-González S, Miranda-Filloy JA, Rodríguez-Rodríguez L, Morado IC, Gomez-Vaquero C, Blanco R, Sopeña B, Ortego-Centeno N, Unzurrunzaga A, Marí-Alfonso B, Sánchez-Martín J, García-Villanueva MJ, Hidalgo-Conde A, Pazzola G, Boiardi L, Salvarani C, González-Gay MA, Martín J. Evidence of association of the NLRP1 gene with giant cell arteritis. Ann Rheum Dis. 2013;72:628-630. https://doi.org/10.1136/annrheumdis-2012-202609
  23. Ly KH, Régent A, Tamby MC, Mouthon L. Pathogenesis of giant cell arteritis: more than just an inflammatory condition? Autoimmun Rev. 2010;9:635-645. https://doi.org/10.1016/j.autrev.2010.05.002
  24. Terrier B, Geri G, Chaara W, Allenbach Y, Rosenzwajg M, Costedoat-Chalumeau N, Fouret P, Musset L, Benveniste O, Six A, Klatzmann D, Saadoun D, Cacoub P. Interleukin-21 Modulates Th1 and Th17 Responses in Giant Cell Arteritis, Th17 and Th1 T-cell responses in Giant Cell Arteritis. Arthritis Rheum. 2012;64(6):2001-2011. https://doi.org/10.1002/art.34327
  25. Márquez A, Hernández-Rodríguez J, Cid MC, Solans R, Castañeda S, Fernández-Contreras ME, Ramentol M, Morado IC, Narváez J, Gómez-Vaquero C, Martínez-Taboada VM, Ortego-Centeno N, Sopeña B, Monfort J, García-Villanueva MJ, Caminal-Montero L, de Miguel E, Blanco R; Spanish GCA Consortium, Palm O, Molberg O, Latus J, Braun N, Moosig F, Witte T, Beretta L, Santaniello A, Pazzola G, Boiardi L, Salvarani C, González-Gay MA, Martín J. Influence of the IL17A locus in giant cell arteritis susceptibility. Ann Rheum Dis. 2014;73:1742-1745. https://doi.org/10.1136/annrheumdis-2014-205261
  26. Espígol-Frigolé G, Corbera-Bellalta M, Planas-Rigol E, Lozano E, Segarra M, García-Martínez A, Prieto-González S, Hernández-Rodríguez J, Grau JM, Rahman MU, Cid MC. IncreasedIL-17A expression in temporal artery lesions is a predictor of sustained response to glucocorticoid treatment in patients with giant-cell arteritis. Ann Rheum Dis. 2013;72:1481-1487. https://doi.org/10.1136/annrheumdis-2012-201836
  27. Deng J, Younge BR, Olshen RA, Goronzy JJ, Weyand CM. Th17 and Th1 T-cell responses in giant cell arteritis. Circulation. 2010;121:906-915. https://doi.org/10.1161/CIRCULATIONAHA.109.872903
  28. Weyand CM, Liao YJ, Goronzy JJ. The immunopathology of giant cell arteritis: diagnostic and therapeutic implications. J Neuroophthalmol. 2012;32(3):259-265. https://doi.org/10.1097/WNO.0b013e318268aa9b
  29. Stanford SM, Bottini N. PTPN22: the archetypal non-HLA autoimmunity gene. Nat Rev Rheumatol. 2014;10(10):602-611. https://doi.org/10.1038/nrrheum.2014.109
  30. Zhang J, Zahir N, Jiang Q, Miliotis H, Heyraud S, Meng X, Dong B, Xie G, Qiu F, Hao Z, McCulloch CA, Keystone EC, Peterson AC, Siminovitch KA. The autoimmune disease-associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness. Nat Genet. 2011;43:902-907. https://doi.org/10.1038/ng.904
  31. Bird AP, Wolffe AP. Methylation-induced repression—belts, braces, and chromatin. Cell. 1999;99(5):451-454.
  32. Brunet A, Berger SL. Epigenetics of aging and aging-related disease. J Gerontol A Biol Sci Med Sci. 2014;69(Suppl.1):S17-20. https://doi.org/10.1093/gerona/glu042
  33. Zhang Y, Zhao M, Sawalha AH, Richardson B, Lu Q. Impaired DNA methylation and its mechanisms in CD4(+)T cells of systemic lupus erythematosus. J Autoimmun. 2013;41:92-99. https://doi.org/10.1016/j.jaut.2013.01.005
  34. Gupta B, Hawkins RD. Epigenomics of autoimmune diseases. Immunol Cell Biol. 2015;93(3):271-276. https://doi.org/10.1038/icb.2015.18
  35. Coit P, De Lott LB, Nan B, Elner VM, Sawalha AH. DNA methylation analysis of the temporal artery microenvironment in giant cell arteritis. Ann Rheum Dis. 2016;75:1196-1202. https://doi.org/10.1136/annrheumdis-2014-207116

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