Incomplete thrombotic microangiopathy as a variant of hemolytic-uremic syndrome

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Kozlovskaya N.L.

Department of Nephrology and Hemodialysis, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia;
Research Department of Nephrology, Research Center, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia

Chebotareva N.V.

Medical University «Russian University of Friendship of Peoples» Ministry of Health of the Russian Federation, Moscow, Russia, 117198

Nikogosova A.D.

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia

Dem'ianova K.A.

Kafedra nefrologii i gemodializa instituta professional'nogo obrazovaniia GBOU VPO "Pervyĭ MGMU im. I.M. Sechenova" Minzdrava Rossii

Varshavskiĭ V.A.

Kafedra patologicheskoĭ anatomii im. A.I. Strukova GBOU VPO "Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova" Minzdrava Rossii

RSCI AuthorID: 117184

Roshchupkina S.V.

UKB #3, Klinika nefrologii, vnutrennikh i professional'nykh bolezneĭ im. E.M. Tareeva GBOU VPO "Pervyĭ MGMU im. I.M. Sechenova" Minzdrava Rossii

Incomplete thrombotic microangiopathy as a variant of hemolytic-uremic syndrome

Authors:

Kozlovskaya N.L., Chebotareva N.V., Nikogosova A.D., Dem'ianova K.A., Varshavskiĭ V.A., Roshchupkina S.V.

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Journal: Therapeutic Archive. 2016;88(6): 77‑79

DOI: 10.17116/terarkh201688677-79

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To cite this article:

Kozlovskaya NL, Chebotareva NV, Nikogosova AD, Dem'ianova KA, Varshavskiĭ VA, Roshchupkina SV. Incomplete thrombotic microangiopathy as a variant of hemolytic-uremic syndrome. Therapeutic Archive. 2016;88(6):77‑79. (In Russ.)
https://doi.org/10.17116/terarkh201688677-79

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The described case illustrates difficulties in diagnosing atypical hemolytic-uremic syndrome (aHUS) in incomplete thrombotic microangiopathy (TMA) in the absence of thrombocytopenia, one of the signs of the classic triad of aHUS, which has resulted in the delayed verification of its diagnosis and in progressive kidney injury. The paper discusses the need to carry out kidney biopsy and to include sHUS in both the presence of a complete set of symptoms of this disease and in the absence of one of them into a range of diagnostic search.

Keywords:

atypical hemolytic-uremic syndrome

incomplete thrombotic microangiopathy

progressive renal failure

Authors:

Kozlovskaya N.L.

Department of Nephrology and Hemodialysis, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia;
Research Department of Nephrology, Research Center, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia

Chebotareva N.V.

Medical University «Russian University of Friendship of Peoples» Ministry of Health of the Russian Federation, Moscow, Russia, 117198

Nikogosova A.D.

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia

Dem'ianova K.A.

Kafedra nefrologii i gemodializa instituta professional'nogo obrazovaniia GBOU VPO "Pervyĭ MGMU im. I.M. Sechenova" Minzdrava Rossii

Varshavskiĭ V.A.

Kafedra patologicheskoĭ anatomii im. A.I. Strukova GBOU VPO "Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova" Minzdrava Rossii

RSCI AuthorID: 117184

Roshchupkina S.V.

UKB #3, Klinika nefrologii, vnutrennikh i professional'nykh bolezneĭ im. E.M. Tareeva GBOU VPO "Pervyĭ MGMU im. I.M. Sechenova" Minzdrava Rossii

List of references:

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Kozlovskaya N, Demyanova K, Kuznetsov D, Kuchieva A, Bobrova L, Stolyarevich E. Atypical haemolytic uremic syndrome with «subclinical» thrombotic microangiopathy: a single case or regularity? Nefrologiay i Dialis. 2014;16(2):280-287. (In Russ.)

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