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Kamyshova E.S.

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia

Shvetsov M.Iu.

Kafedra nefrologii i gemodializa FPPOV Pervogo MGMU im. I.M. Sechenova Minzdrava Rossii

Kutyrina I.M.

Otdel nefrologii NII uronefrologii i reproduktivnogo zdorov'ia cheloveka, kafedra nefrologii i gemodializa FPPOV Pervogo MGMU im. I.M. Sechenova Minzdrava Rossii

Burdennyy A.M.

Institute of General Pathology and Pathophysiology, 8 Baltiiskaya St., Moscow, Russian Federation, 125315

Zheng A.

M.V. Lomonosov Moscow State University, Moscow, Russia

Nosikov V.V.

Institut biokhimicheskoĭ fiziki im. N.M. Émanuélia RAN

Bobkova I.N.

Otdel nefrologii NII uronefrologii i reproduktivnogo zdorov'ia cheloveka Pervogo MGMU im. I.M. Sechenova Minzdrava Rossii

Clinical value of TNF, IL-6, and IL-10 gene polymorphic markers in chronic glomerulonephritis

Authors:

Kamyshova E.S., Shvetsov M.Iu., Kutyrina I.M., Burdennyy A.M., Zheng A., Nosikov V.V., Bobkova I.N.

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Journal: Therapeutic Archive. 2016;88(6): 45‑50

DOI: 10.17116/terarkh201688645-50

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CLINICAL VALUE OF TNF, IL-6, AND IL-10 GENE POLYMORPHIC MARKERS IN CHRONIC GLOMERULONEPHRITIS
CLINICAL VALUE OF TNF, IL-6, AND IL-10 GENE POLYMORPHIC MARKERS IN CHRONIC GLOMERULONEPHRITIS

To cite this article:

Kamyshova ES, Shvetsov MIu, Kutyrina IM, Burdennyy AM, Zheng A, Nosikov VV, Bobkova IN. Clinical value of TNF, IL-6, and IL-10 gene polymorphic markers in chronic glomerulonephritis. Therapeutic Archive. 2016;88(6):45‑50. (In Russ.)
https://doi.org/10.17116/terarkh201688645-50

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Abstract:

Aim. To study the association of the polymorphic markers (PMs) G(-238)A of the TNF gene, G(–174)C of the IL-6 gene, and G(–1082)A of the IL-10 gene with the clinical characteristics of chronic glomerulonephritis (CGN) and a response to immunosuppressive therapy (IST). Subjects and methods. Clinical syndromes at the time of diagnosis, the morphological types of nephritis, and a response to IST were analyzed in relation to the carriage of the examined PMs of the TNF, IL-6, and IL-10 genes in 102 patients with CGN.  Results. No association was found between the PM G(-238)A of the TNF gene and the clinical features of CGN. The carriers of the C allele of the PM G(-174) C of the IL-6 gene versus the homozygous individuals were observed to have more frequently kidney dysfunction at the time of diagnosis (р=0.014). Hypertension was more common in the carriers of the AA genotype of the PM G(-1082)A of the IL-10 gene (p=0.023); moreover, they tended to have a more frequent concurrence of nephrotic syndrome and hypertension (p=0.082). Analysis of the distribution of the morphological types of CGN disclosed that the proliferative variants were more common in the patients with the GG genotype (the TNF gene) as compared to the A allele carriers (p=0.067); and the nonproliferative forms were in the individuals homozygous for GG (the IL-6 gene) as compared to the C allele carriers (p=0.067). Examination of an IST response showed that a complete response at 12 months of treatment occurred more frequently in the carriers of the C allele of the IL-6 gene (p=0.045) and in those of the GG genotypes of the IL-10 gene (p=0.030). Conclusion. There was an association of the PMs G(–174)C of the IL-6 gene and G(–1082)A of the IL-10 gene with the clinical features of CGN and a response to IST.

Keywords:

chronic glomerulonephritis
polymorphic marker
TNF gene
IL-6 gene
IL-10 gene

Authors:

Kamyshova E.S.

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia

Shvetsov M.Iu.

Kafedra nefrologii i gemodializa FPPOV Pervogo MGMU im. I.M. Sechenova Minzdrava Rossii

Kutyrina I.M.

Otdel nefrologii NII uronefrologii i reproduktivnogo zdorov'ia cheloveka, kafedra nefrologii i gemodializa FPPOV Pervogo MGMU im. I.M. Sechenova Minzdrava Rossii

Burdennyy A.M.

Institute of General Pathology and Pathophysiology, 8 Baltiiskaya St., Moscow, Russian Federation, 125315

Zheng A.

M.V. Lomonosov Moscow State University, Moscow, Russia

Nosikov V.V.

Institut biokhimicheskoĭ fiziki im. N.M. Émanuélia RAN

Bobkova I.N.

Otdel nefrologii NII uronefrologii i reproduktivnogo zdorov'ia cheloveka Pervogo MGMU im. I.M. Sechenova Minzdrava Rossii

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