Seronegative celiac disease: A case report

Krums L.M.; Parfenov A.I.; Sabel'nikova E.A.; Poleva N.I.; Bykova S.V.; Dubtsova E.A.; Gudkova R.B.; Khomeriki S.G.; Rotin D.L.; Pavlov M.V.; Starostina N.S.

doi:https://doi.org/10.17116/terarkh201688275-77

Krums L.M.

Moskovskiĭ klinicheskiĭ nauchno-prakticheskiĭ tsentr

Parfenov A.I.

GBUZ "Moskovskiĭ klinicheskiĭ nauchno-prakticheskiĭ tsentr" Departamenta zdravookhraneniia Moskvy

Sabel'nikova E.A.

Moskovskiĭ klinicheskiĭ nauchno-prakticheskiĭ tsentr

Poleva N.I.

TsNII gastroénterologii Departamenta zdravookhraneniia Moskvy

Bykova S.V.

Moskovskiĭ klinicheskiĭ nauchno-prakticheskiĭ tsentr. TsNII gastronterologii Departamenta zdravookhraneniia Moskvy

Dubtsova E.A.

TsNII gastroénterologii Departamenta zdravookhraneniia Moskvy

Gudkova R.B.

GBUZ "Tsentral'nyĭ nauchno-issledovatel'skiĭ institut gastroénterologii" Departamenta zdravookhraneniia Moskvy

Khomeriki S.G.

Moscow Clinical Research and Practical Centre, Moscow Health Department, Central Research Institute of Gastroenterology, Moscow

Rotin D.L.

Moscow Clinical Scientific and Practical Center of Moscow Healthcare Department, Moscow, Russia

Pavlov M.V.

Moscow Clinical Research and Practical Center, Moscow Healthcare Department, Moscow, Russia

Starostina N.S.

Institut khirurgii im. A.V. Vishnevskogo Minzdravsotsrazvitiia RF

Seronegative celiac disease: A case report

Authors:

Krums L.M., Parfenov A.I., Sabel'nikova E.A., Poleva N.I., Bykova S.V., Dubtsova E.A., Gudkova R.B., Khomeriki S.G., Rotin D.L., Pavlov M.V., Starostina N.S.

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Journal: Therapeutic Archive. 2016;88(2): 75‑77

DOI: 10.17116/terarkh201688275-77

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To cite this article:

Krums LM, Parfenov AI, Sabel'nikova EA, et al. . Seronegative celiac disease: A case report. Therapeutic Archive. 2016;88(2):75‑77. (In Russ.)
https://doi.org/10.17116/terarkh201688275-77

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Abstract:

The paper describes a rare case of celiac disease in the absence of serum anti-tissue transglutaminase (anti-tTG) antibodies. A 51-year-old patient has been suffering from diarrheas for 20 years. He has lost 15 kg gradually; weakness progressed; muscle cramps, leg edemas, and signs of dynamic pseudoobstruction appeared. Morphological examination revealed small intestinal mucosal (SIM) villous atrophy (Marsh IIIC stage). IgA anti-tTG and IgG anti-tTG antibodies were 0.086 and 0.178, respectively. The patient was prescribed a gluten-free diet, water electrolyte solutions to correct metabolic disturbances, and prednisolone. During a control examination after 6 months, the patient had no complaints and gained 22 kg, and the SIM villus height was increased. The specific feature of the case is specific negative serological tests for celiac disease.

Keywords:

serological tests

small and large intestinal pseudoobstruction

small intestine mucosal atrophy

Authors:

Krums L.M.

Moskovskiĭ klinicheskiĭ nauchno-prakticheskiĭ tsentr

Parfenov A.I.

GBUZ "Moskovskiĭ klinicheskiĭ nauchno-prakticheskiĭ tsentr" Departamenta zdravookhraneniia Moskvy

Sabel'nikova E.A.

Moskovskiĭ klinicheskiĭ nauchno-prakticheskiĭ tsentr

Poleva N.I.

TsNII gastroénterologii Departamenta zdravookhraneniia Moskvy

Bykova S.V.

Moskovskiĭ klinicheskiĭ nauchno-prakticheskiĭ tsentr. TsNII gastronterologii Departamenta zdravookhraneniia Moskvy

Dubtsova E.A.

TsNII gastroénterologii Departamenta zdravookhraneniia Moskvy

Gudkova R.B.

GBUZ "Tsentral'nyĭ nauchno-issledovatel'skiĭ institut gastroénterologii" Departamenta zdravookhraneniia Moskvy

Khomeriki S.G.

Moscow Clinical Research and Practical Centre, Moscow Health Department, Central Research Institute of Gastroenterology, Moscow

Rotin D.L.

Moscow Clinical Scientific and Practical Center of Moscow Healthcare Department, Moscow, Russia

Pavlov M.V.

Moscow Clinical Research and Practical Center, Moscow Healthcare Department, Moscow, Russia

Starostina N.S.

Institut khirurgii im. A.V. Vishnevskogo Minzdravsotsrazvitiia RF

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References:

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