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Gritsaev S.V.

Rossiĭskiĭ NII gematologii i transfuziologii, Sankt-Peterburg;
K/O "Gematologiia"

Kostroma I.I.

Rossiĭskiĭ NII gematologii i transfuziologii FMBA Rossii, Sankt-Peterburg

Ryadnova G.M.

Russian Research Institute of Hematology and Transfusiology, Federal Biomedical Agency of Russia, Moscow, Russia

Tiranova S.A.

FGBU "Rossiĭskiĭ NII gematologii i transfuziologii" FMBA, Sankt-Peterburg

Chubukina Zh.V.

Rossiĭskiĭ NII gematologii i transfuziologii

Balashova V.A.

Russian Research Institute of Hematology and Transfusiology, Federal Biomedical Agency of Russia, Moscow, Russia

Zenina M.N.

Russian Research Institute of Hematology and Transfusiology, Federal Biomedical Agency of Russia, Moscow, Russia

Martynkevich I.S.

Klinicheskiĭ otdel "Gematologiia" Rossiĭskogo nauchno-issledovatel'skogo instituta gematologii i transfuziologii, Sankt-Peterburg

Potikhonova N.A.

Klinicheskiĭ otdel "Gematologiia" Rossiĭskogo nauchno-issledovatel'skogo instituta gematologii i transfuziologii, Sankt-Peterburg

Abdulkadyrov K.M.

Rossiĭskiĭ NII gematologii i transfuziologii, Sankt-Peterburg;
K/O "Gematologiia"

The specific features of diagnosis of mixed-phenotype acute leukemia: A combination of B-cell antigen expressions according to the results of flow cytometry and morphological markers of myeloid differentiation in blast cells: A clinical case

Authors:

Gritsaev S.V., Kostroma I.I., Ryadnova G.M., Tiranova S.A., Chubukina Zh.V., Balashova V.A., Zenina M.N., Martynkevich I.S., Potikhonova N.A., Abdulkadyrov K.M.

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Journal: Therapeutic Archive. 2015;87(7): 97‑100

DOI: 10.17116/terarkh201587797-100

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THE SPECIFIC FEATURES OF DIAGNOSIS OF MIXED-PHENOTYPE ACUTE LEUKEMIA: A COMBINATION OF B-CELL ANTIGEN EXPRESSIONS ACCORDING TO THE RESULTS OF FLOW CYTOMETRY AND MORPHOLOGICAL MARKERS OF MYELOID DIFFERENTIATION IN BLAST CELLS: A CLINICAL CASE
THE SPECIFIC FEATURES OF DIAGNOSIS OF MIXED-PHENOTYPE ACUTE LEUKEMIA: A COMBINATION OF B-CELL ANTIGEN EXPRESSIONS ACCORDING TO THE RESULTS OF FLOW CYTOMETRY AND MORPHOLOGICAL MARKERS OF MYELOID DIFFERENTIATION IN BLAST CELLS: A CLINICAL CASE

To cite this article:

Gritsaev SV, Kostroma II, Ryadnova GM, et al. . The specific features of diagnosis of mixed-phenotype acute leukemia: A combination of B-cell antigen expressions according to the results of flow cytometry and morphological markers of myeloid differentiation in blast cells: A clinical case. Therapeutic Archive. 2015;87(7):97‑100. (In Russ.)
https://doi.org/10.17116/terarkh201587797-100

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Abstract:

This rare type of acute leukemia, blast cells of which express myeloid and/or lymphoid markers, is mainly diagnosed using flow cytometric findings. The paper describes a clinical case of mixed-phenotype acute leukemia, in which B-cell lymphoid antigen expressions were revealed by a flow cytometric technique, while bone marrow morphological specimens showed the signs of myeloid differentiation specific to blast cells. It is concluded that there is a need for a comprehensive examination of patients with new-onset acute leukemia and for an aggregate analysis of flow cytometric results with morphological and cytochemical findings.

Keywords:

acute myeloid leukemia
mixed-phenotype

Authors:

Gritsaev S.V.

Rossiĭskiĭ NII gematologii i transfuziologii, Sankt-Peterburg;
K/O "Gematologiia"

Kostroma I.I.

Rossiĭskiĭ NII gematologii i transfuziologii FMBA Rossii, Sankt-Peterburg

Ryadnova G.M.

Russian Research Institute of Hematology and Transfusiology, Federal Biomedical Agency of Russia, Moscow, Russia

Tiranova S.A.

FGBU "Rossiĭskiĭ NII gematologii i transfuziologii" FMBA, Sankt-Peterburg

Chubukina Zh.V.

Rossiĭskiĭ NII gematologii i transfuziologii

Balashova V.A.

Russian Research Institute of Hematology and Transfusiology, Federal Biomedical Agency of Russia, Moscow, Russia

Zenina M.N.

Russian Research Institute of Hematology and Transfusiology, Federal Biomedical Agency of Russia, Moscow, Russia

Martynkevich I.S.

Klinicheskiĭ otdel "Gematologiia" Rossiĭskogo nauchno-issledovatel'skogo instituta gematologii i transfuziologii, Sankt-Peterburg

Potikhonova N.A.

Klinicheskiĭ otdel "Gematologiia" Rossiĭskogo nauchno-issledovatel'skogo instituta gematologii i transfuziologii, Sankt-Peterburg

Abdulkadyrov K.M.

Rossiĭskiĭ NII gematologii i transfuziologii, Sankt-Peterburg;
K/O "Gematologiia"

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