Cytogenetic profile in patients with primary myelodysplastic syndrome

Gritsaev S.V.

Rossiĭskiĭ NII gematologii i transfuziologii, Sankt-Peterburg;
K/O "Gematologiia"

Martynkevich I.S.

Klinicheskiĭ otdel "Gematologiia" Rossiĭskogo nauchno-issledovatel'skogo instituta gematologii i transfuziologii, Sankt-Peterburg

Petrova E.V.

National research of Tomsk State University, City Hospital №2, Tomsk

Martynenko L.S.

Klinicheskiĭ otdel "Gematologiia" Rossiĭskogo nauchno-issledovatel'skogo instituta gematologii i transfuziologii, Sankt-Peterburg

Ivanova M.P.

Klinicheskiĭ otdel "Gematologiia" Rossiĭskogo nauchno-issledovatel'skogo instituta gematologii i transfuziologii, Sankt-Peterburg

Aksenova V.Iu.

Klinicheskiĭ otdel "Gematologiia" Rossiĭskogo nauchno-issledovatel'skogo instituta gematologii i transfuziologii, Sankt-Peterburg

Tsybakova N.Iu.

Klinicheskiĭ otdel "Gematologiia" Rossiĭskogo nauchno-issledovatel'skogo instituta gematologii i transfuziologii, Sankt-Peterburg

Potikhonova N.A.

Klinicheskiĭ otdel "Gematologiia" Rossiĭskogo nauchno-issledovatel'skogo instituta gematologii i transfuziologii, Sankt-Peterburg

Abdulkadyrov K.M.

Rossiĭskiĭ NII gematologii i transfuziologii, Sankt-Peterburg;
K/O "Gematologiia"

Cytogenetic profile in patients with primary myelodysplastic syndrome

Authors:

Gritsaev S.V., Martynkevich I.S., Petrova E.V., Martynenko L.S., Ivanova M.P., Aksenova V.Iu., Tsybakova N.Iu., Potikhonova N.A., Abdulkadyrov K.M.

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Journal: Therapeutic Archive. 2013;85(7): 43‑49

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To cite this article:

Gritsaev SV, Martynkevich IS, Petrova EV, et al. . Cytogenetic profile in patients with primary myelodysplastic syndrome. Therapeutic Archive. 2013;85(7):43‑49. (In Russ.)

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Aim. To analyze the prevalence of chromosome aberrations presented in the revised International Prognostic Scoring System (R-IPSS) in patients with de novo myelodysplastic syndrome (MDS). Subjects and methods. Chromosome aberrations were analyzed in 197 patients aged 14 to 86 years (median age 64 years) with de novo MDS. Results. Karyotype abnormalities were revealed in 129 (65.5%) patients with de novo MDS. According to the IPSS criteria, the karyotypes found 52 (26.4%) patients were assigned to an intermediate prognostic group whereas in accordance with the R-IPSS guidelines, an intermediate karyotype group included chromosome abnormalities in 32 (16.2%) patients. Out of 5 R-IPSS prognostic types, the favorable karyotype group was the largest (48.2%). The very favorable and unfavorable karyotype groups comprised few patients with MDS: 3 and 3.6%, respectively. Despite the fact that it was not mentioned in the R-IPSS, a monosomal karyotype was verified in 24 (12.2%) patients There was a correlation of the (normal and complex) karyotype with bone marrow blast counts (r=0.469; p=0.000), but not with age. Conclusion. A variety of cytogenetic damages cannot identify the prognostic potential of all chromosome aberrations occurring in patients with MDS even if prognostic factors increased up to 5.

Keywords:

de novo myelodysplastic syndrome

karyotype

R-IPS

Authors:

Gritsaev S.V.

Rossiĭskiĭ NII gematologii i transfuziologii, Sankt-Peterburg;
K/O "Gematologiia"

Martynkevich I.S.

Klinicheskiĭ otdel "Gematologiia" Rossiĭskogo nauchno-issledovatel'skogo instituta gematologii i transfuziologii, Sankt-Peterburg

Petrova E.V.

National research of Tomsk State University, City Hospital №2, Tomsk

Martynenko L.S.

Klinicheskiĭ otdel "Gematologiia" Rossiĭskogo nauchno-issledovatel'skogo instituta gematologii i transfuziologii, Sankt-Peterburg

Ivanova M.P.

Klinicheskiĭ otdel "Gematologiia" Rossiĭskogo nauchno-issledovatel'skogo instituta gematologii i transfuziologii, Sankt-Peterburg

Aksenova V.Iu.

Klinicheskiĭ otdel "Gematologiia" Rossiĭskogo nauchno-issledovatel'skogo instituta gematologii i transfuziologii, Sankt-Peterburg

Tsybakova N.Iu.

Klinicheskiĭ otdel "Gematologiia" Rossiĭskogo nauchno-issledovatel'skogo instituta gematologii i transfuziologii, Sankt-Peterburg

Potikhonova N.A.

Klinicheskiĭ otdel "Gematologiia" Rossiĭskogo nauchno-issledovatel'skogo instituta gematologii i transfuziologii, Sankt-Peterburg

Abdulkadyrov K.M.

Rossiĭskiĭ NII gematologii i transfuziologii, Sankt-Peterburg;
K/O "Gematologiia"

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