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Vorob’ev V.I.

S.P. Botkin State Clinical Hospital, Moscow, Russia

Kravchenko S.K.

Gematologicheskiĭ nauchnyĭ tsentr Minzdrava Rossii

Kovrigina A.M.

Nauchno-klinicheskoe otdelenie gematologicheskoĭ khirurgii Gematologicheskogo nauchnogo tsentra Minzdrava RF, Moskva

Successful therapy for enteropathy-associated peripheral T-cell lymphoma using high-dose polychemotherapy and autologous hematopoietic stem cell transplantation

Authors:

Vorob’ev V.I., Kravchenko S.K., Kovrigina A.M.

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Journal: Therapeutic Archive. 2013;85(7): 79‑83

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SUCCESSFUL THERAPY FOR ENTEROPATHY-ASSOCIATED PERIPHERAL T-CELL LYMPHOMA USING HIGH-DOSE POLYCHEMOTHERAPY AND AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION
SUCCESSFUL THERAPY FOR ENTEROPATHY-ASSOCIATED PERIPHERAL T-CELL LYMPHOMA USING HIGH-DOSE POLYCHEMOTHERAPY AND AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION

To cite this article:

Vorob’ev VI, Kravchenko SK, Kovrigina AM. Successful therapy for enteropathy-associated peripheral T-cell lymphoma using high-dose polychemotherapy and autologous hematopoietic stem cell transplantation. Therapeutic Archive. 2013;85(7):79‑83. (In Russ.)

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Abstract:

Enteropathy-associated T-cell lymphoma (EATL) is a rare disease that accounts for not more than 1.4% of all lymphomas. It is most common in Europe, followed by North America and Asia. The disease is associated with gluten-sensitive celiac disease in 50% of cases and divided into types I and II. Mean-dose CHOP-like therapy is ineffective, with a median overall survival of 7-10 months. With high-dose therapy, 5-year survival rates can be 60%, but it can be used in not more than half of the cases. This is associated with the serious somatic status of most patients at diagnosis and with a median age of 57-64 years. The article presents a literature review and a case of successful therapy in a 58-year-old patient with type I EATL using the mNHL-BFM-90 protocol and autologous hematopoietic stem cell transplantation.

Keywords:

enteropathy-associated T-cell lymphoma
celiac disease
NHL-BFM-90
autologous hematopoietic stem cell transplantation

Authors:

Vorob’ev V.I.

S.P. Botkin State Clinical Hospital, Moscow, Russia

Kravchenko S.K.

Gematologicheskiĭ nauchnyĭ tsentr Minzdrava Rossii

Kovrigina A.M.

Nauchno-klinicheskoe otdelenie gematologicheskoĭ khirurgii Gematologicheskogo nauchnogo tsentra Minzdrava RF, Moskva

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