Forensic characteristics of the cardio-toxic effect of organophosphorus compounds

Zarafyants G.N.

Saint Petersburg State University;
Academician I.P. Pavlov First Saint Petersburg State Medical University

Popov V.L.

Pavlov First Saint Petersburg State Medical University

ORCID: 0000-0001-7058-9541

Forensic characteristics of the cardio-toxic effect of organophosphorus compounds

Authors:

Zarafyants G.N., Popov V.L.

More about the authors

Journal: Forensic Medical Expertise. 2021;64(5): 32‑35

DOI: 10.17116/sudmed20216405132

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To cite this article:

Zarafyants GN, Popov VL. Forensic characteristics of the cardio-toxic effect of organophosphorus compounds. Forensic Medical Expertise. 2021;64(5):32‑35. (In Russ.)
https://doi.org/10.17116/sudmed20216405132

Подписка 2025-2 (Forensic Medical Expertise)

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Objective — to identify the morphological equivalents of the cardiotoxic action of organophosphate poisoning. It was studied 110 fatal organophosphate poisonings in toxicogenic and somatogenic stages. The study of the heart was a comprehensive in term of clinical, biochemical, histological, micromorphometric, histochemical and histoenzymological approaches. We have identified a complex of deep metabolic disorders and necrobiotic changes in the heart muscle and the level of cholinesterase activity inhibition in the cholinergic structures of the heart in the toxicogenic and somatogenic stages of fatal organophosphate poisoning.

Keywords:

fatal organophosphate poisoning

cardiotoxic effect

inhibition of acetylcholinesterase

forensic medical examination

Authors:

Zarafyants G.N.

Saint Petersburg State University;
Academician I.P. Pavlov First Saint Petersburg State Medical University

Popov V.L.

Pavlov First Saint Petersburg State Medical University

ORCID: 0000-0001-7058-9541

Received:

24.03.2021

Accepted:

17.04.2021

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Receiver 24.03.2021

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