Comparison of two types of sorbents for solid-phase extraction of cannabimimetic MDMB(N)-073F metabolites from urine

Kataev S.S.; Dvorskaya O.N.; Gofenberg M.A.

doi:https://doi.org/10.17116/sudmed20216401129

Kataev S.S.

Perm Regional Bureau of Forensic Medical Examination

ORCID: 0000-0001-6742-2054

Dvorskaya O.N.

Perm State Pharmaceutical Academy of the Ministry of Health

Gofenberg M.A.

Regional Narcological Hospital;
Ural State Medical University of the Ministry of Health of Russia

Comparison of two types of sorbents for solid-phase extraction of cannabimimetic MDMB(N)-073F metabolites from urine

Authors:

Kataev S.S., Dvorskaya O.N., Gofenberg M.A.

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Journal: Forensic Medical Expertise. 2021;64(1): 29‑33

DOI: 10.17116/sudmed20216401129

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To cite this article:

Kataev SS, Dvorskaya ON, Gofenberg MA. Comparison of two types of sorbents for solid-phase extraction of cannabimimetic MDMB(N)-073F metabolites from urine. Forensic Medical Expertise. 2021;64(1):29‑33. (In Russ.)
https://doi.org/10.17116/sudmed20216401129

Подписка 2026 Судебно-медицинская экспертиза (Forensic Medical Expertise)

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Abstract:

The purpose of this work is to study the possibility of using cartridges with a mixed sorbent C8/SAX for the extraction of synthetic cannabimimetic metabolites MDMB (N)-073F from urine. It was used enzymatic hydrolysis of urine, solid phase extraction using cartridges C8/SAX and C8/SCX with mixed phase, derivatization and gas chromatography with a mass spectrometric detector. The results of the study allow us to recommend cartridges for solid-phase extraction with an anion-exchange phase (C8/SAX or SAX) when conducting a targeted study for the presence of cannabimimetics metabolites that have compounds with a carboxyl group as the main metabolites.

Keywords:

synthetic cannabimimetics

MDMB (N) -073F

solid phase extraction

gas chromatography — mass spectrometry

Authors:

Kataev S.S.

Perm Regional Bureau of Forensic Medical Examination

ORCID: 0000-0001-6742-2054

Dvorskaya O.N.

Perm State Pharmaceutical Academy of the Ministry of Health

Gofenberg M.A.

Regional Narcological Hospital;
Ural State Medical University of the Ministry of Health of Russia

Received:

05.07.2020

Accepted:

07.08.2020

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References:

Melentyev AB, Kataev SS, Dvorskaya ON. Dizaynerskiyenarkotiki. Metabolizm i podkhody k analizu v biologicheskikh sredakh. M.: Pero; 2016. (In Russ.).
Saudan C, Augsburger M, Mangin P, Saugy M. Carbon isotopic ratio analysis by gas chromatography/combustion/isotope ratio mass spectrometry for the detection of gamma-hydroxybutyric acid (GHB) administration to humans. Rapid Commun. Mass Spectrom. 2007;21:3956-3962. https://doi.org/10.1002/rcm.3298
Stanley SMR, Owens NA, Rodgers JP. Detection of flunixin in equine urine using high-performance liquid chromatography with particle beam and atmospheric pressure ionization mass spectrometry after solid-phase extraction. J Chromatography B. 1995;667(1):95-103. https://doi.org/10.1016/0378-4347(94)00603-3
Dixit VA, Dixit VM. Unique solid-phase extraction column for isolation of 11-nor-delta-9-tetrahydrocannabinol-9-carboxylic acid from in human urine. J Liquid Chromatogr. 1990;13(16):3313-3325.
Yamamoto E, Takakuwa S, Kato T, Asakawa N. Sensitive determination of aspirin and its metabolites in plasma by LC-UV using on-line solid-phase extraction with methylcellulose-immobilized anion-exchange restricted access media. J Chromatogr B AnalytTechnol Biomed Life Sci. 2007;846(1-2):132-138. https://doi.org/10.1016/j.jchromb.2006.08.037
Zheng Y, Helander A. Solid-phase extraction procedure for ethyl glucuronide in urine. J Anal Toxicol. 2008;32(9):778-781. https://doi.org/10.1093/jat/32.9.778
Hegstad S, Johnsen L, Mørland J, Christophersen AS. Determination of ethylglucuronide in oral fluid by ultra-performance liquid chromatography-tandem mass spectrometry. J Anal Toxicol. 2009;33(4):204-207. https://doi.org/10.1093/jat/33.4.204
Kataev SS, Dvorskaya ON, Gofenberg MA. Identification of cannabimimetic MDMB(N)-073F metabolites in urine by method of gas chromatography with mass spectrometric detection. Pharmaciya i Pharmacoloiya. 2019;7:2: 4-12. (In Russ.). https://doi.org/10.19163/2307-9266-2019-7-2-4-12
https://doi.org/10.30906/0023-1134-2017-51-3-36-40 https://doi.org/10.1007/s11094-017-1585-4
Kataev SS, Dvorskaya ON, Krokhin IP. Optimization of the solid-phase extraction procedure for the screening of the medicinal and narcotic substances in the blood by gas chromatography with mass-spectrometric detection. Sudebno-meditsinskaya ekspertiza. 2017;60(1):29-35. (In Russ.). https://doi.org/10.17116/sudmed201760129-35