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Voronin A.V.

Samara State Medical University

Malkova T.L.

Perm State Pharmaceutical Academy

Synbulatov I.V.

Samara State Medical University

Forecast of the metrological characteristics of the method of the quantitative determination of verapamil in blood in forensic chemical analysis

Authors:

Voronin A.V., Malkova T.L., Synbulatov I.V.

More about the authors

Journal: Forensic Medical Expertise. 2020;63(6): 35‑38

DOI: 10.17116/sudmed20206306135

Views: 1121

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Table of contents

FORECAST OF THE METROLOGICAL CHARACTERISTICS OF THE METHOD OF THE QUANTITATIVE DETERMINATION OF VERAPAMIL IN BLOOD IN FORENSIC CHEMICAL ANALYSIS
FORECAST OF THE METROLOGICAL CHARACTERISTICS OF THE METHOD OF THE QUANTITATIVE DETERMINATION OF VERAPAMIL IN BLOOD IN FORENSIC CHEMICAL ANALYSIS

To cite this article:

Voronin AV, Malkova TL, Synbulatov IV. Forecast of the metrological characteristics of the method of the quantitative determination of verapamil in blood in forensic chemical analysis. Forensic Medical Expertise. 2020;63(6):35‑38. (In Russ.)
https://doi.org/10.17116/sudmed20206306135

Подписка 2025-2 (Forensic Medical Expertise)
 
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The aim of the work is to test theoretical prognosis of metrological characteristics of methods of quantitative determination in forensic chemical analysis on the example of method of determination of verapamil content in blood by thin layer chromatography with computer densitometry. The algorithm of prognostic determination of relative error for methods of quantitative analysis in forensic chemical examination using computer program «ChemMetrEvaluation 1.0» is offered. The implementation of the algorithm is based on a detailed analysis of error estimation of measurements at the stages of sample preparation, measuring the value of the analytical signal.

Keywords:

forensic chemical analysis
verapamil
metrological characteristics
quantitative determination

Authors:

Voronin A.V.

Samara State Medical University

Malkova T.L.

Perm State Pharmaceutical Academy

Synbulatov I.V.

Samara State Medical University

Received:

19.04.2020

Accepted:

26.05.2020

List of references:

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  2. Gorbacheva TV, Bychkov VA. Organization of quality control of the forensic medical investigations. Sudebno-meditsinskaya expertisa. 2018;61(5):21-24. (In Russ.). https://doi.org/10.17116/sudmed20186105121
  3. Voronin AV. Razrabotka metodologicheskikh osnov issledovaniya otdel’nykh mnogokomponentnykh ob’ektov analiticheskogo kontrolya v sudebno-khimicheskoi ekspertize i farmatsevticheskom analize: Dis. ... d-ra farm. nauk. Samara. 2019.
  4. Kvachakhia LL, Shormanov VK. Determination of verapamil in biological fluids. Pharmaciya. 2015;2:19-22. (In Russ.).
  5. Melnikov ES, Belova MV, Rodina TA, Ramenskaya GV. Determination of some antihypertensive drugs in blood plasma by high performance liquid chromatography/tandem mass spectrometry in the analysis of acute poisonings. Sorptionnye i chromatographycheskie processys. 2015;15(2):257-268. (In Russ.).
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  7. Problemy zloupotrebleniya lekarstvennymi preparatami i novymi psikhoaktivnymi veshchestvami. Materialy 4-i Vserossiiskoi nauchno-prakticheskoi konferentsii s mezhdunarodnym uchastiem. Perm’: FGBOU VO PGFA Minzdrava Rossii; 2018.
  8. Voronin AV, Malkova TL. Densitometricheskoe opredelenie opiatov, barbituratov, verapamila pri sudebno-khimicheskom issledovanii krovi. Metodicheskie rekomendatsii. M.: RTsSME; 2019. (In Russ.).
  9. Metodicheskie rekomendatsii po validatsii analiticheskikh metodik, ispol’zuemykh v sudebno-khimicheskom i khimiko-toksikologicheskom analize biologicheskogo materiala. M.: RTsSME; 2014. (In Russ.).
  10. Voronin AV, Synbulatov IV, Kachalkin MN, Voronin SV. Svidetel’stvo o gosudarstvennoi registratsii programmy dlya EVM №2019617347 ot 06.06.19. «Chem Metr Evaluation 1.0» [Elektronnyi resurs]: Baza patentov Rossii. Accesset 17 Mart, 2020. (In Russ.). https://patentinform.ru/programs/reg-2019617347.html
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