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Barsegian S.S.

Biuro sudebno-meditsinskoĭ ékspertizy Departamenta zdravookhraneniia Moskvy

Kiryushin A.N.

Central Chemical Toxicological Laboratory of I.M. Sechenov First Moscow State Medical University, Russian Ministry of Health, Moscow, Russia, 119991

Eroshchenko N.N.

Central Chemical Toxicological Laboratory of I.M. Sechenov First Moscow State Medical University, Russian Ministry of Health, Moscow, Russia, 119991

Tuaeva N.O.

Laboratory of Analytical Toxicology, V.P Serbsky Federal Medical Research Centre of Psychiatry and Narcology, Ministry of Health of the Russia, Moscow, Russia, 119002

Nosyrev A.E.

Laboratory of Analytical Toxicology, V.P Serbsky Federal Medical Research Centre of Psychiatry and Narcology, Ministry of Health of the Russia, Moscow, Russia, 119002;
Bureau of Forensic Medical Expertise, Moscow Health Department, Moscow, Russia, 115516

Kirilyuk A.A.

Laboratory of Metrological Support of Biological and Information Technologies, All-Russian Research Institute of Metrological Services, Moscow, Russia, 119361

The detection of the 25B-NBOMe derivative of phenylethylamine in the biological material

Authors:

Barsegian S.S., Kiryushin A.N., Eroshchenko N.N., Tuaeva N.O., Nosyrev A.E., Kirilyuk A.A.

More about the authors

Journal: Forensic Medical Expertise. 2019;62(2): 34‑39

DOI: 10.17116/sudmed20196202134

Views: 2109

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Table of contents

THE DETECTION OF THE 25B-NBOME DERIVATIVE OF PHENYLETHYLAMINE IN THE BIOLOGICAL MATERIAL
THE DETECTION OF THE 25B-NBOME DERIVATIVE OF PHENYLETHYLAMINE IN THE BIOLOGICAL MATERIAL

To cite this article:

Barsegian SS, Kiryushin AN, Eroshchenko NN, Tuaeva NO, Nosyrev AE, Kirilyuk AA. The detection of the 25B-NBOMe derivative of phenylethylamine in the biological material. Forensic Medical Expertise. 2019;62(2):34‑39. (In Russ.)
https://doi.org/10.17116/sudmed20196202134

Подписка 2025-2 (Forensic Medical Expertise)
 
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This article is focused on the conditions for the detection and identification of 2-(4-bromo-2.5-dimethoxyl]-N-[(2-methoxyphenyl)methyl] ethamine (25B-NBOMe) and its major metabolites by the combination of the HPLC/MS/MS techniques. The high-resolution mass spectra obtained with the use of a linear ion trap are described. The results of the study give evidence of the possibility for the detection of the analytes within 24 hours after drug consumption and within 3 months after the storage of the biological material of interest in a refrigerator at a temperature of 3—5 °C. The data obtained confirmed high stability of 2-(4-bromo-2.5-dimethoxyl]-N-[(2-methoxyphenyl)methyl] ethamine and its metabolites in the biological tissues.

Keywords:

25B-NBOMe
narcotic drugs
tandem mass-spectrometry
metabolites

Authors:

Barsegian S.S.

Biuro sudebno-meditsinskoĭ ékspertizy Departamenta zdravookhraneniia Moskvy

Kiryushin A.N.

Central Chemical Toxicological Laboratory of I.M. Sechenov First Moscow State Medical University, Russian Ministry of Health, Moscow, Russia, 119991

Eroshchenko N.N.

Central Chemical Toxicological Laboratory of I.M. Sechenov First Moscow State Medical University, Russian Ministry of Health, Moscow, Russia, 119991

Tuaeva N.O.

Laboratory of Analytical Toxicology, V.P Serbsky Federal Medical Research Centre of Psychiatry and Narcology, Ministry of Health of the Russia, Moscow, Russia, 119002

Nosyrev A.E.

Laboratory of Analytical Toxicology, V.P Serbsky Federal Medical Research Centre of Psychiatry and Narcology, Ministry of Health of the Russia, Moscow, Russia, 119002;
Bureau of Forensic Medical Expertise, Moscow Health Department, Moscow, Russia, 115516

Kirilyuk A.A.

Laboratory of Metrological Support of Biological and Information Technologies, All-Russian Research Institute of Metrological Services, Moscow, Russia, 119361

List of references:

  1. Poklis JL, Devers KG, Arbefeville EF, Pearson JM, Houston E, Poklis A. Postmortem detection of 25I-NBOMe [2-(4-iodo-2, 5-dimethoxyphenyl)-N-[(2-methoxyphenyl) methyl] ethanamine] in fluids and tissues determined by high performance liquid chromatography with tandem mass spectrometry from a traumatic death. Forensic science international. 2014;234:e14-e20. https://doi.org/10.1016/j.forsciint.2013.10.015
  2. Nikolaou P, Papoutsis I, Stefanidou M, Spiliopoulou C, Athanaselis S. 2C-I-NBOMe, an «N-bomb» that kills with «Smiles». Toxicological and legislative aspects. Drug and chemical toxicology. 2015;38(1):113-119. https://doi.org/10.3109/01480545.2014.911882
  3. Suzuki J, Dekker MA, Valent ES, Cruz FAA, Correa AM, Poklis JL, Poklis A. Toxicities associated with NBOMe ingestion-a novel class of potent hallucinogens: a review of the literature. Psychosomatics. 2015;56(2):129-139. https://doi.org/10.1016/j.psym.2014.11.002
  4. Kristofic JJ, Chmiel JD, Jackson GF, Vorce SP, Holler JM, Robinson SL, Bosy TZ. Detection of 25C-NBOMe in three related cases. Journal of analytical toxicology. 2016;40(6):466-472. https://doi.org/10.1093/jat/bkw035
  5. Gee P, Schep LJ, Jensen BP, Moore G, Barrington S. Case series: toxicity from 25B-NBOMe — a cluster of N-bomb cases. Clinical Toxicology. 2016;54(2):141-146. https://doi.org/10.3109/15563650.2015.1115056
  6. Leth-Petersen S, Gabel-Jensen C, Gillings N, Lehel S, Hansen HD, Knudsen GM, Kristensen JL. Metabolic fate of hallucinogenic NBOMes. Chemical research in toxicology. 2016;29(1):96-100. https://doi.org/10.1021/acs.chemrestox.5b00450
  7. Temporal KDH, Scott KS, Mohr AL, Logan BK. Metabolic Profile Determination of NBOMe Compounds Using Human Liver Microsomes and Comparison with Findings in Authentic Human Blood and Urine. Journal of Analytical Toxicology. 2017;1:41(7):646-657. https://doi.org/10.1093/jat/bkx029
  8. Nielsen LM, Holm NB, Leth-Petersen S, Kristensen JL, Olsen L, Linnet K. Characterization of the hepatic cytochrome P450 enzymes involved in the metabolism of 25I-NBOMe and 25I-NBOH. Drug testing and analysis. 2017;9(5):671-679. https://doi.org/10.1002/dta.2031
  9. Wohlfarth A, Roman M, Andersson M, Kugelberg FC, Diao X, Carlier J, Huestis MA. 25C-NBOMe and 25I-NBOMe metabolite studies in human hepatocytes, in vivo mouse and human urine with high-resolution mass spectrometry. Drug testing and analysis. 2017;9(5):680-698. https://doi.org/10.1002/dta.2044
  10. Poklis JL, Clay DJ, Poklis A. High-performance liquid chromatography with tandem mass spectrometry for the determination of nine hallucinogenic 25-NBOMe designer drugs in urine specimens. Journal of Analytical Toxicology. 2014;38(3):113-121. https://doi.org/10.1093/jat/bku005
  11. Poklis JL, Raso SA, Alford KN, Poklis A, Peace MR. Analysis of 25I-NBOMe, 25B-NBOMe, 25C-NBOMe and other dimethoxyphenyl-N-[(2-methoxyphenyl) methyl] ethanamine derivatives on blotter paper. Journal of analytical toxicology. 2016;39(8):617-623. https://doi.org/10.1093/jat/bkv073
  12. Soh YNA, Elliott S. An investigation of the stability of emerging new psychoactive substances. Drug testing and analysis. 2014;6(7-8):696-704.
  13. Poklis JL, Nanco CR, Troendle MM, Wolf CE, Poklis A. Determination of 4-bromo-2,5-dimethoxy-N-[(2-methoxyphenyl)methyl]-benzeneethanamine (25B-NBOMe) in serum and urine by high performance liquid chromatography with tandem mass spectrometry in a case of severe intoxication. Drug testing and analysis. 2014;6(7-8):764-769. https://doi.org/10.1002/dta.1522
  14. Poklis JL, Dempsey SK, Liu K, Ritter JK, Wolf C, Zhang S, Poklis A. Identification of metabolite biomarkers of the designer hallucinogen 25I-NBOMe in mouse hepatic microsomal preparations and human urine samples associated with clinical intoxication. Journal of analytical toxicology. 2016;39(8):607-616. https://doi.org/10.1093/jat/bkv079

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