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Pigolkin Yu.I.

Sechenov’s First Moscow State Medical University, Moscow, Russia

Dolzhansky O.V.

Petrovsky Russian Research Center for Surgery, Moscow, Russia

Zolotenkova G.V.

Kafedra sudebnoĭ meditsiny Pervogo MGMU im. I.M. Sechenova

Ametrin M.D.

Department of Forensic Medicine, I.M. Sechenov First Moscow State Medical University, Ministry of Health of the Russia, Moscow, Russia, 119021;
Bureau of forensic medical expertise, Moscow Health Department, Moscow, Russia, 115516

Zolotenkov D.D.

Department of Forensic Medical Expertise, I.M. Sechenov First Moscow State Medical University, Ministry of Health of the Russia, Moscow, Russia, 119991

The forensic medical estimation of the biological age of the corpse based on the morphological changes in the skin

Authors:

Pigolkin Yu.I., Dolzhansky O.V., Zolotenkova G.V., Ametrin M.D., Zolotenkov D.D.

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Journal: Forensic Medical Expertise. 2018;61(4): 32‑34

DOI: 10.17116/sudmed201861432

Read: 1742 times

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Table of contents

THE FORENSIC MEDICAL ESTIMATION OF THE BIOLOGICAL AGE OF THE CORPSE BASED ON THE MORPHOLOGICAL CHANGES IN THE SKIN
THE FORENSIC MEDICAL ESTIMATION OF THE BIOLOGICAL AGE OF THE CORPSE BASED ON THE MORPHOLOGICAL CHANGES IN THE SKIN

To cite this article:

Pigolkin YuI, Dolzhansky OV, Zolotenkova GV, Ametrin MD, Zolotenkov DD. The forensic medical estimation of the biological age of the corpse based on the morphological changes in the skin. Forensic Medical Expertise. 2018;61(4):32‑34. (In Russ.)
https://doi.org/10.17116/sudmed201861432

Подписка 2026 Судебно-медицинская экспертиза (Forensic Medical Expertise)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

The objective of the present work was the immunohistochemical evaluation of the age-related dynamics of apoptosis-associated proteins contained in the human skin epidermis. We studied the samples of skin tissues obtained during the forensic medical expertises of 100 corpses of the subjects who died in the consequence of acute blood loss in the absence of injuries or pathological changes in the skin (56 men and 44 women at the age varying from 5 to 85 years). The results of this study give evidence that the histoimmunological investigations of the skin tissues can be carried out with the use of the mmunohistochemical Ki67, bcl-2, and p53 markers for the more accurate determination of the biological age of the deceased subjects. The quantitative characteristics thus obtained serve as reliable indicators of the chronic changes in the skin and can be used as the components of the combined diagnostic procedures.

Keywords:

age-related changes in the skin
immunohistochemical markers
biological age

Authors:

Pigolkin Yu.I.

Sechenov’s First Moscow State Medical University, Moscow, Russia

Dolzhansky O.V.

Petrovsky Russian Research Center for Surgery, Moscow, Russia

Zolotenkova G.V.

Kafedra sudebnoĭ meditsiny Pervogo MGMU im. I.M. Sechenova

Ametrin M.D.

Department of Forensic Medicine, I.M. Sechenov First Moscow State Medical University, Ministry of Health of the Russia, Moscow, Russia, 119021;
Bureau of forensic medical expertise, Moscow Health Department, Moscow, Russia, 115516

Zolotenkov D.D.

Department of Forensic Medical Expertise, I.M. Sechenov First Moscow State Medical University, Ministry of Health of the Russia, Moscow, Russia, 119991

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References:

  1. Glybochko PV, Pigolkin YuI, Nikolenko VN, Zolotenkova GV, Efimov AA, Alekseev YuD, Fedulova MV, Savenkova EN, Kurzin LM, Goncharova NN,Yurchenko MA, Miroshnichenko NV. Sudebno-medicinskaja diagnostika vozrasta. M.: Pervyj MGMU in I.M. Sechenova. 2016. (In Russ.)
  2. Pigolkin YuI, Poletaeva MP, Zolotenkova GV, Volkov AV. The age-specific changes in the histological structure of the thyroid cartilage in the men. Sudebno-meditsinskaya ekspertiza. 2017;60(5):11-14. (In Russ.) https://doi.org/10.17116/sudmed201760511-14
  3. Pigolkin YuI, Garcia Corro MA, Zolotenkova GV. The age-dependent changes of sella turcica, frontal and sphenoid sinuses. Sudebno-meditsinskaya ekspertiza. 2016;59(6):48-53. (In Russ.) https://doi.org/10.17116/sudmed201659648-534
  4. Pigolkin YuI, Zolotenkova GV, Velenko PS, Izotov BN. The investigations into the amino acid composition of the tooth for the purpose of forensic medical personality identification. Sudebno-meditsinskaya ekspertiza. 2017;60(1):42-45. (In Russ.) https://doi.org/10.17116/sudmed201760142-45
  5. Pashinyan GA, Ayub F, Belyaeva EV. The current state of identity of a person on dental status: a review. Sudebno-meditsinskaya ekspertiza. 1996;39(4):52-54. (In Russ.)
  6. Korkmaz U, Korkmaz N, Yazici S. Anemia as a risk factor for low bone mineral density in postmenopausal Turkish women. European Federation of Internal Medicine (EFIM). 2012;23(2):154-158. https://doi.org/10.1016/j.ejim.2011.11.009
  7. Johnell O, Kanis JA. An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Internacional. 2006;17:1726-1733.
  8. Rutten EP, Franssen FM, Spruit MA, Wouters EF. Anemia is associated with bone mineral density in chronic obstructive pulmonary disease. COPD. 2013;10(3)286-292. https://doi.org/10.3109/15412555.2012.744390
  9. Benoist HM, Seck Diallo A, Diop S. Periodontal conditions in young sickle cell anemia Senegalese patients. Dakar Medical. 2008;53(2):91-98.
  10. Hatipoglu H, Hatipoglu MG, Cagirankaya LB, Caglayan F. Severe periodontal destruction in a patient with advanced anemia: a case report. European Journal of Dentistry. 2012;6(1):95-100.
  11. Zolotenkova GV, Tkachenko SB, Pigolkin YuI. The modern non-invasive methods for the evaluation of the age-specific changes in the skin. Sudebno-meditsinskaya ekspertiza. 2015;58(1):26-30. (In Russ.) https://doi.org/:10.17116/sudmed201558126-30
  12. Sarkisov DS, Perov YuL. Mikroskopicheskaya tekhnika. M.: Meditsina, 1996. (In Russ.)
  13. Rukovodstvo po immunogistohimicheskoj diagnostike opuholej cheloveka: (monografiya). Pod red. Petrova SV, Rajkhlina NT. Kazan’: Titul, 2004. (In Russ.)
  14. Glants S. Mediko-biologicheskaya statistika. Praktika. 1999. (In Russ.)
  15. Kanitakis J. Anatomy, histology and immunohisto-chemistry of normal human skin. European Journal of Dermatology. 2002;12(4):390-399.
  16. Leontyuk AS, Sluka BA. Osnovy vozrastnoi gistologii: ucheb. posobie. M.: Vysh shk, 2000. (In Russ.)
  17. Meissner C, Ritz-Timme S. Molecular pathology and age estimation. Forensic Science International. 2010;203(1):34-43. https://doi.org/10.1016/j.forsciint.2010.07.010
  18. Einspahr JG, Alberts DS, Warneke JA. Relationship of p53 mutations to epidermal cell proliferation and apoptosis in human UV-induced skin carcinogenesis. Neoplasia. 1999;1(5):468-475. https://doi.org/10.1038/sj.neo.7900061
  19. Kakasheva-Mazhenkovska L, Milenkova L, Kostovska N, Gjokik G. Histomorphometrical characteristics of human skin from capillitium in subjects of different age. Prilozi. 2011;32(2):105-118.
  20. Carpenter PM, Linden KG, McLaren CE. Nuclear morphometry and molecular biomarkers of actinic keratosis, sundamaged, and nonexposed skin. Cancer Epidemiology, Biomarkers & Prevention. 2004;13(12):1996-1920.
  21. Puschmann S, Rahn CD, Wenck H, Gallinat S, Fischer F. Approach to quantify human dermal skin aging using multiphoton laser scanning microscopy. J Biomed Opt. 2012 Mar;17(3):036005. https://doi.org/10.1117/1.JBO.17.3.036005
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