The peculiar features of the distribution of 2-metoxy-4-(1-propenyl)-hydroxybenzene in the organism of the warm-blooded animals

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Shormanov V.K.

Kurskiĭ gosudarstvennyĭ meditsinskiĭ universitet

Tsatsua E.P.

State budgetary educational institution of higher professional education "Kursk State Medical University", Russian Ministry of Health, Kursk, Russia, 305041

Astashkina A.P.

GBOU VPO "Kurskiĭ gosudarstvennyĭ meditsinskiĭ universitet"

Vorob’eva O.A.

Department of Pharmaceutical Chemistry and Pharmacognosia, Nizhni Novgorod State Medical Academy, Nizhni Novgorod, Russia, 603005

Mastikhina Yu.A.

Department of Pharmaceutical, Toxicological and analytical Chemistry, Kursk State Medical University, Ministry of Health of the Russia, Kursk, Russia, 305041

The peculiar features of the distribution of 2-metoxy-4-(1-propenyl)-hydroxybenzene in the organism of the warm-blooded animals

Authors:

Shormanov V.K., Tsatsua E.P., Astashkina A.P., Vorob’eva O.A., Mastikhina Yu.A.

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Journal: Forensic Medical Expertise. 2018;61(3): 35‑39

DOI: 10.17116/sudmed201861335-39

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To cite this article:

Shormanov VK, Tsatsua EP, Astashkina AP, Vorob’eva OA, Mastikhina YuA. The peculiar features of the distribution of 2-metoxy-4-(1-propenyl)-hydroxybenzene in the organism of the warm-blooded animals. Forensic Medical Expertise. 2018;61(3):35‑39. (In Russ.)
https://doi.org/10.17116/sudmed201861335-39

Подписка 2026 Судебно-медицинская экспертиза (Forensic Medical Expertise)

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Abstract:

The present study was designed to elucidate the distribution patterns of 2-metoxy-4-(1-propenyl)-hydroxybenzene in the organism of the warm-blooded animals (rats) after its intragastric administration at a dose equivalent to three 50% lethal doses (LD-50) for this compound. 2-metoxy-4-(1-propenyl)-hydroxybenzene was extracted in the unmodified form from the organs and blood of the dead animals after the dualfold infusion of the tissues with ethyl-acetate and purification by chromatography on a macrocolumn with silica gel L 40/100 mcm making use of the hexane-acetone mixture (7:3) mobile phase as the eluent. TLC, HPLC, and UV-spectrometry were employed to identify and quantify the analyte. The study has demonstrated the presence of unmetabolized 2-metoxy-4-(1-propenyl)-hydroxybenzene in the organs and blood of the poisoned animals. The largest amounts of this compound (expressed in milligrams per 100 g of the tissue) were accumulated in the stomach with its contents (236.22±28.21), small intestine with their contents (122.29±15.55), lungs (44.28±2.10), and spleen (44.00±4.70).

Keywords:

2-metoxy-4-(1-propenyl)-hydroxybenzene (isoeugenol)

distribution in the body

chemical toxicological investigation

Authors:

Shormanov V.K.

Kurskiĭ gosudarstvennyĭ meditsinskiĭ universitet

Tsatsua E.P.

State budgetary educational institution of higher professional education "Kursk State Medical University", Russian Ministry of Health, Kursk, Russia, 305041

Astashkina A.P.

GBOU VPO "Kurskiĭ gosudarstvennyĭ meditsinskiĭ universitet"

Vorob’eva O.A.

Department of Pharmaceutical Chemistry and Pharmacognosia, Nizhni Novgorod State Medical Academy, Nizhni Novgorod, Russia, 603005

Mastikhina Yu.A.

Department of Pharmaceutical, Toxicological and analytical Chemistry, Kursk State Medical University, Ministry of Health of the Russia, Kursk, Russia, 305041

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References:

Isoeugenol. Pub Chem. Open chemistry database. https://pubchem.ncbi.nlm.nih.gov/compound/Isoeugenol
Hyldgaard M, Meyer RL, Peng M, Hibberd AA, Fischer J, Sigmundsson A, Mygind T. Binary combination of epsilon-poly-L-lysine and isoeugenol affect progression of spoilage microbiota in fresh turkey meat, and delay onset of spoilage in Pseudomonas putida challenged meat. Int J Food Microbiol. 2015;215:131-142. https://doi.org/10.1016/j.ijfoodmicro.2015.09.014
Kaur B, Chakraborty D. Biotechnological and molecular approaches for vanillin production: a review. Appl Biochem Biotechnol. 2013;169(4):1353-1372. https://doi.org/10.1007/s12010-012-0066-1
Zhao LQ, Sun ZH, Zheng P, Zhu LL. Biotransformation of isoeugenol to vanillin by a novel strain of Bacillus fusiformis. Biotechnol Lett. 2005;27(19):1505-1509. https://doi.org/10.1007/s10529-005-1466-x
Yamada M, Okada Y, Yoshida T, Nagasawa T. Biotransformation of isoeugenol to vanillin by Pseudomonas putida IE27 cells. PPL Microbiol. Biotechnol. 2007;73(5):1025-1030. https://doi.org/10.1007/s00253-006-0569-1
Li YH, Sun ZH, Zhao LQ, Xu Y. Bioconversion of isoeugenol into vanillin by crude enzyme extracted from soybean. Appl Biochem Biotechnol. 2005;125(1):1-10.
Сhimicheskaya encyclopediya. Vol. 2. M. Bolshaya Rossiiskaya encyclopediya. 1990. (In Russ.)
Zielinski GM, Burke LA, Samokhvalov A. Selective activation of C=C bond in sustainable phenolic compounds from lignin via photooxidation: experiment and density functional theory calculations. Photochem Photobiol. 2015;91(6):1332-1339. https://doi.org/10.1111/php.12509
Isoeugenol. 2-methoxy-4-(1-methylvinyl)phenol. http://www.thegoodscentscompany.com/data/rw1006911.html
Kienhuis AS, Slob W, Gremmer ER, Vermeulen J, Ezendam J. A dose response modeling approach shows that effects from mixture exposure to the skin sensitizers isoeugenol and cinnamal are in line with dose addition and not with synergism. Toxicol Sci. 2015;147(1):68-74. https://doi.org/10.1093/toxsci/kfv109
Arancioglu S, Ulker OC, Karakaya A. Utilization of the ex vivo LLNA: BrdU-ELISA to distinguish the sensitizers from irritants in respect of 3 end points-lymphocyte proliferation, ear swelling, and cytokine profiles. Int J Toxicol. 2015;34(1):24-30. https://doi.org/10.1177/1091581814560613
Astashkina AP, Shormanov VK, Ostanin MA, Grishchenko OI, Elizarova MK. Features of distribution of 2- and 3-methoxy derivatives of hydroxybenzene in the body of warm-blooded animals. Farmaciya. 2013;62(5):5-8. (In Russ.)
Dobroriz AM, Borisenko AN, Cleese VV. The case of the death from poisoning by eugenol. Sudebno-medicinskaya ekspertiza. 2004;47(5):45-46. (In Russ.)
Du Plooy WJ, Swart L, Van Huysteen GW. Poisoning with boophane disticha: a forensic case. Hum Exp Toxicol. 2001;20(5):277-278. https://doi.org/10.1191/096032701678227749
Shormanov VK, Ostanin MA, Astashkina AP, Grishchenko OI, Tcatcua EP. Features of distribution of 4-methoxyhydroxybenzoli the body of warm-blooded animals in case of deathly poisoning. Sudebno-medicinskaya ekspertiza. 2016;59(4):48-53. (In Russ.) https://doi.org/10.17116/sudmed201659129-34
Shormanov VK, Pugacheva OI, Astashkina AP, Tcatcua EP. Features of distribution of 2,6-di-tert-buthyl4-methylhydroxybenxoli in the body of warm-blooded animals. Sudebno-medicinskaya ekspertiza. 2016;59(1):29-34. (In Russ.) https://doi.org/10.17116/sudmed201659448-53

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