The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Morozov Iu.E.

Baltiĭskiĭ federal'nyĭ universitet im. Immanuila Kanta, Kaliningrad

Velenko P.S.

Department of Forensic Medicine, I.M. Sechenov First Moscow State Medical University, Russian Ministry of Health, Moscow, Russia, 119435

The characteristic of protein biosynthesis in brain neurons with chronic alcohol intoxication

Authors:

Morozov Iu.E., Velenko P.S.

More about the authors

Journal: Forensic Medical Expertise. 2018;61(1): 49‑51

DOI: 10.17116/sudmed201861149-51

Read: 1357 times

Download PDF (RU)
Contact the author
Table of contents

THE CHARACTERISTIC OF PROTEIN BIOSYNTHESIS IN BRAIN NEURONS WITH CHRONIC ALCOHOL INTOXICATION
THE CHARACTERISTIC OF PROTEIN BIOSYNTHESIS IN BRAIN NEURONS WITH CHRONIC ALCOHOL INTOXICATION

To cite this article:

Morozov IuE, Velenko PS. The characteristic of protein biosynthesis in brain neurons with chronic alcohol intoxication. Forensic Medical Expertise. 2018;61(1):49‑51. (In Russ.)
https://doi.org/10.17116/sudmed201861149-51

Подписка 2026 Судебно-медицинская экспертиза (Forensic Medical Expertise)
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Abstract:

The objective of the present study was to evaluate the possibilities for the use of the changes in the AgNOR staining patterns in the neurons of the dorsal raphe nucleus (DRN) for the purposes of the medical differential diagnostics of the cases of death from chronic alcohol intoxication. We elucidated the characteristics of the activity of protein biosynthesis including the number and the area of the nucleoli in the nuclei of the neurons of the individuals who had died from chronic alcohol intoxication (n=20) in comparison with the subjects of the control group (n=13). To reveal the morphological structures associated with protein biosynthesis in the nucleoli of the serotoninergic neurons of the dorsal raphe nucleus in the brain, the histological preparations were stained with the use of the silver-staining technique for nucleolar organizer regions (AgNOR). The comparative statistical analysis of the results thus obtained with the calculated confidence coefficients was carried out. The aggregated analysis of all the dorsal raphe subnuclei revealed the impairment of the AgNOR staining characteristics in the neurons of the subjects who had died from chronic alcohol intoxication in comparison with those of the subjects comprising the control group. It is concluded that the results of the study can be used for differential diagnostics of deaths from chronic alcohol intoxication and other causes.

Keywords:

chronic alcohol intoxication
neurons of dorsal raphe nucleus
AgNOR staining characteristics of the neurons

Authors:

Morozov Iu.E.

Baltiĭskiĭ federal'nyĭ universitet im. Immanuila Kanta, Kaliningrad

Velenko P.S.

Department of Forensic Medicine, I.M. Sechenov First Moscow State Medical University, Russian Ministry of Health, Moscow, Russia, 119435

Close metadata

References:

  1. Krzyżanowska M, Steiner J, Karnecki K, Kaliszan M, Brisch R, Wiergowski M, Braun K, Jankowski Z, Gos T. Decreased ribosomal DNA transcription in dorsal raphe nucleus neurons differentiates between suicidal and non-suicidal death. European Archives of Psychiatry and Clinical Neuroscience. 2015;266(3):217-224. https://doi.org/10.1007/s00406-015-0655-4
  2. Kovalev AV, Bogomolov DV, Kul'bitsky BN, Zavalishina LE, Fedulova MV. The immunohistochemical study of the structures of the cardiac conduction system in the case of death from alcoholic cardiomyopathy. Sudebno-medicinskaja ekspertiza. 2015;58(2):30-31. (In Russ.) https://doi.org/10.17116/sudmed 201558230-31
  3. Pigolkin JuI, Morozov JuE. Neurohistochemical researches of enzymes in forensic medicine. Tihookeanskij medicinskij zhurnal. 2012;1:76-80. (In Russ.)
  4. Gos T, Steiner J, Jankowski Z, Bogerts B. Postmortem-Assessed Impairment of Neuronal Activity in Depression: The Dominant Impact of Suicide. CNS & Neurological Disorders - Drug Targets. 2013;12(7):930-935. https://doi.org/10.2174/18715273113129990094
  5. Gos T, Krell D, Brish R, Bielau H, Trubner K, Steiner J, Bernstein H-G, Bogerts B. Demonstration of decreased activity of dorsal raphe nucleus neurons in depressed suicidal patients by the AgNOR staining method. Journal of Affective Disorders. 2008;111:251-260. https://doi.org/10.1016/j.jad.2008.03.002
  6. Pigolkin JuI, Morozov JuE, Mamedov VK. Medicolegal diagnosis of sharp and chronic alcoholic intoxication. Sudebno-medicinskaja ekspertiza. 2012;55(1):30-33. (In Russ.)
  7. Mc Gowan PO, Szyf M. The epigenetics of social adversity in early life: implications for mental health outcomes. Neurobiol Dis. 2010;39:66-72. https://doi.org/10.1016/j.nbd.2009.12.026
  8. Andrade R., Haj-Dahmane S. Serotonin neuron diversity in the dorsal raphe. ACS ChemNeurosci. 2013;4:22-25. https://doi.org/10.1021/cn300224n
  9. Ploton D. Structure and molecular organization of the nucleolus. ZentralblPathol. 1994;140:3-6.
  10. Gerasimov AN. Meditsinskaya statistika: uchebnoe posobie. M. OOO MIA, 2007. (In Russ.)
  11. Sirri V, Urcuqui-Inchima S, Roussel P. Nucleolus: the fascinating nuclear body. Histochem Cell Biol. 2008;129:13-31. https://doi.org/10.1007/s00418-007-0359-6
  12. Gomes C, Smith SC, Youssef MN. RNA polymerase 1-driven transcription as a mediator of BDNF-induced neurite outgrowth. J. Biol.Chem. 2011;286:4357-4363. https://doi.org/10.1074/jbc.M110.170134
  13. Raska I, Shaw PJ, Cmarko D. New insights into nucleolar architecture and activity. Int. Rev. Cytol. 2006;225:177-235. https://doi.org/10.1016/S0074-7696(06)55004-1
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.