The detection and identification of alpha-pyrrolidino-valerophenone (α-PVP) and its metabolites in the objects of the forensic chemical examination

Moskaleva E.V.; Eroshchenko N.N.; Kiryushin A.N.; Kardonsky D.A.; Eganov A.A.

doi:https://doi.org/10.17116/sudmed201760119-22

Moskaleva E.V.

Central Chemical Toxicological Laboratory of I.M. Sechenov First Moscow State Medical University, Russian Ministry of Health, Moscow, Russia, 119991

Eroshchenko N.N.

Central Chemical Toxicological Laboratory of I.M. Sechenov First Moscow State Medical University, Russian Ministry of Health, Moscow, Russia, 119991

Kiryushin A.N.

Central Chemical Toxicological Laboratory of I.M. Sechenov First Moscow State Medical University, Russian Ministry of Health, Moscow, Russia, 119991

Kardonsky D.A.

Central Chemical Toxicological Laboratory of I.M. Sechenov First Moscow State Medical University, Russian Ministry of Health, Moscow, Russia, 119991

Eganov A.A.

Central Chemical Toxicological Laboratory of I.M. Sechenov First Moscow State Medical University, Russian Ministry of Health, Moscow, Russia, 119991

The detection and identification of alpha-pyrrolidino-valerophenone (α-PVP) and its metabolites in the objects of the forensic chemical examination

Authors:

Moskaleva E.V., Eroshchenko N.N., Kiryushin A.N., Kardonsky D.A., Eganov A.A.

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Journal: Forensic Medical Expertise. 2017;60(1): 19‑22

DOI: 10.17116/sudmed201760119-22

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To cite this article:

Moskaleva EV, Eroshchenko NN, Kiryushin AN, Kardonsky DA, Eganov AA. The detection and identification of alpha-pyrrolidino-valerophenone (α-PVP) and its metabolites in the objects of the forensic chemical examination. Forensic Medical Expertise. 2017;60(1):19‑22. (In Russ.)
https://doi.org/10.17116/sudmed201760119-22

Подписка 2026 Судебно-медицинская экспертиза (Forensic Medical Expertise)

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Abstract:

The combined application of the IK 200609 chemical toxicological analyzer and the diagnostic biosensor (reagent) for the determination of synthetic cations (with due regard for compliance with the instruction for analysis) made it possible to detect during 15 minutes the presence of cations in the urine samples at the concentration of 376.64 ng/ml. This result was further confirmed by HPLC-Ms/MS and GH-MS. The use of the analyzer allowed the screening of the urine samples to be performed within several minutes at the preliminary stage of the study. A simplified method of tissue sample preparation with the use of the kits for extraction and solid-phase purification is proposed together with a variant of blood sample preparation with the use of filtration. The proposed approach can be employed for the rapid detection and identification of alpha-pyrrolidino-valerophenone (α-PVP) and its metabolites in urine, blood and tissues of various organs for the purpose of practical toxicological investigations in the framework of forensic chemical expertise.

Keywords:

alpha-pyrrolidino-valerophenone (α-PVP)

chemical toxicological investigations

HPLC-Ms/MS

GH-MS

Authors:

Moskaleva E.V.

Central Chemical Toxicological Laboratory of I.M. Sechenov First Moscow State Medical University, Russian Ministry of Health, Moscow, Russia, 119991

Eroshchenko N.N.

Central Chemical Toxicological Laboratory of I.M. Sechenov First Moscow State Medical University, Russian Ministry of Health, Moscow, Russia, 119991

Kiryushin A.N.

Central Chemical Toxicological Laboratory of I.M. Sechenov First Moscow State Medical University, Russian Ministry of Health, Moscow, Russia, 119991

Kardonsky D.A.

Central Chemical Toxicological Laboratory of I.M. Sechenov First Moscow State Medical University, Russian Ministry of Health, Moscow, Russia, 119991

Eganov A.A.

Central Chemical Toxicological Laboratory of I.M. Sechenov First Moscow State Medical University, Russian Ministry of Health, Moscow, Russia, 119991

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