The specific features of the distribution of 4-metoxyhydroxybenzene in the organism of the warm-blooded animals suffering lethal intoxication

Shormanov V.K.; Astashkina A.P.; Ostanin M.A.; Grishechko O.I.; Tsatsua E.P.

doi:https://doi.org/10.17116/sudmed201659448-53

Shormanov V.K.

Kurskiĭ gosudarstvennyĭ meditsinskiĭ universitet

Astashkina A.P.

GBOU VPO "Kurskiĭ gosudarstvennyĭ meditsinskiĭ universitet"

Ostanin M.A.

GUZ Tul'skoĭ oblasti "Tul'skaia oblastnaia klinicheskaia bol'nitsa"

Grishechko O.I.

GBOU VPO "Kurskiĭ gosudarstvennyĭ meditsinskiĭ universitet"

Tsatsua E.P.

State budgetary educational institution of higher professional education "Kursk State Medical University", Russian Ministry of Health, Kursk, Russia, 305041

The specific features of the distribution of 4-metoxyhydroxybenzene in the organism of the warm-blooded animals suffering lethal intoxication

Authors:

Shormanov V.K., Astashkina A.P., Ostanin M.A., Grishechko O.I., Tsatsua E.P.

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Journal: Forensic Medical Expertise. 2016;59(4): 48‑53

DOI: 10.17116/sudmed201659448-53

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Shormanov VK, Astashkina AP, Ostanin MA, Grishechko OI, Tsatsua EP. The specific features of the distribution of 4-metoxyhydroxybenzene in the organism of the warm-blooded animals suffering lethal intoxication. Forensic Medical Expertise. 2016;59(4):48‑53. (In Russ.)
https://doi.org/10.17116/sudmed201659448-53

Подписка 2026 Судебно-медицинская экспертиза (Forensic Medical Expertise)

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Abstract:

This work was designed to study the distribution of 4-metoxyhydroxybenzene in the organism of the omnivorous warm-blooded animals (rats) after the intragastric administration of this poisonous compound at a dose three-fold greater than the LD50 value. The administered 4-metoxyhydroxybenzene was isolated from the organs and blood of the experimental animals by exposing the biological tissues to acetone with subsequent purification on a silica gel L 40/100 mcm using a hexane:dioxane:propanol-2 (20:5:1) as the mobile phase. The identification and quantitation of 4-metoxyhydroxybenzene were carried out with the use of TLC, GC-MS, and UF-spectrophotometry. It was shown that the administered 4-metoxyhydroxybenzene remained unmetabolized in the internal organs and blood of the poisoned experimental animals. The largest amounts of 4-metoxyhydroxybenzene were found in the stomach contents (2584,92±117,47), brain (59.49±6.05), contents of small intestines (28.21±3.77), and kidneys (26.13±1.64).

Keywords:

4-metoxyhydroxybenzene

distribution in the body

chemico-toxicological analysis

Authors:

Shormanov V.K.

Kurskiĭ gosudarstvennyĭ meditsinskiĭ universitet

Astashkina A.P.

GBOU VPO "Kurskiĭ gosudarstvennyĭ meditsinskiĭ universitet"

Ostanin M.A.

GUZ Tul'skoĭ oblasti "Tul'skaia oblastnaia klinicheskaia bol'nitsa"

Grishechko O.I.

GBOU VPO "Kurskiĭ gosudarstvennyĭ meditsinskiĭ universitet"

Tsatsua E.P.

State budgetary educational institution of higher professional education "Kursk State Medical University", Russian Ministry of Health, Kursk, Russia, 305041

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References:

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