The modern approaches to the determination of the content of elemental impurities in the pharmaceutical substances with the use of inductively-coupled plasma mass-spectrometry

Bol’shov M.A.; Seregina I.F.; Uspenskaya E.V.; Titorovich O.V.; Syroeshkin A.V.; Maksimova T.V.; Pleteneva T.V.

doi:https://doi.org/10.17116/sudmed201558631-33

Bol’shov M.A.

Department of Analytical Chemistry, Chemical Faculty, M.V. Lomonosov Moscow State University, Moscow, Russia, 119899;
Institute of Spectroscopy, Russian Academy of Sciences, Moscow, Russia, 142190

Seregina I.F.

Department of Analytical Chemistry, Chemical Faculty, M.V. Lomonosov Moscow State University, Moscow, Russia, 119899

Uspenskaya E.V.

Department of Pharmaceutical and Toxicological Chemistry, Medical Institute of the Russian University of People’s Friendship, Moscow, Russia, 117198

Titorovich O.V.

Department of Pharmaceutical and Toxicological Chemistry, Medical Institute of the Russian University of People’s Friendship, Moscow, Russia, 117198

Syroeshkin A.V.

Department of Pharmaceutical and Toxicological Chemistry, Medical Institute of the Russian University of People’s Friendship, Moscow, Russia, 117198

Maksimova T.V.

Kafedra farmatsevticheskoĭ i toksikologicheskoĭ khimii FGBOU VPO "Rossiĭskiĭ universitet druzhby narodov", Moskva, Rossiia, 117198

Pleteneva T.V.

Kafedra obshcheĭ i klinicheskoĭ farmakologii i kafedra farmatsevticheskoĭ i toksikologicheskoĭ khimii Rossiĭskogo universiteta druzhby narodov

The modern approaches to the determination of the content of elemental impurities in the pharmaceutical substances with the use of inductively-coupled plasma mass-spectrometry

Authors:

Bol’shov M.A., Seregina I.F., Uspenskaya E.V., Titorovich O.V., Syroeshkin A.V., Maksimova T.V., Pleteneva T.V.

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Journal: Forensic Medical Expertise. 2015;58(6): 31‑33

DOI: 10.17116/sudmed201558631-33

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To cite this article:

Bol’shov MA, Seregina IF, Uspenskaya EV, Titorovich OV, Syroeshkin AV, Maksimova TV, Pleteneva TV. The modern approaches to the determination of the content of elemental impurities in the pharmaceutical substances with the use of inductively-coupled plasma mass-spectrometry. Forensic Medical Expertise. 2015;58(6):31‑33. (In Russ.)
https://doi.org/10.17116/sudmed201558631-33

Подписка 2026 Судебно-медицинская экспертиза (Forensic Medical Expertise)

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Abstract:

The elemental impurities contained in the composition of the pharmaceutical dose forms are known to be capable of interacting with their active substances and excipients and of catalyzing their degradation; thereby, they alter stability of the drug products and exert toxic effects on the human tissues. The present publication was designed to report the results of the purity tests for ascorbic acid, valine, and galactose substances by inductively-coupled plasma mass-spectrometry (IBP-MS). This method is recommended for use by the US and EU pharmacopoeias and for the replacement of the traditional test for heavy metals with the use of PbS ethanol suspension.

Keywords:

elemental impurities

pharmaceutical substances

inductively-coupled plasma mass-spectrometry

Authors:

Bol’shov M.A.

Department of Analytical Chemistry, Chemical Faculty, M.V. Lomonosov Moscow State University, Moscow, Russia, 119899;
Institute of Spectroscopy, Russian Academy of Sciences, Moscow, Russia, 142190

Seregina I.F.

Department of Analytical Chemistry, Chemical Faculty, M.V. Lomonosov Moscow State University, Moscow, Russia, 119899

Uspenskaya E.V.

Department of Pharmaceutical and Toxicological Chemistry, Medical Institute of the Russian University of People’s Friendship, Moscow, Russia, 117198

Titorovich O.V.

Department of Pharmaceutical and Toxicological Chemistry, Medical Institute of the Russian University of People’s Friendship, Moscow, Russia, 117198

Syroeshkin A.V.

Department of Pharmaceutical and Toxicological Chemistry, Medical Institute of the Russian University of People’s Friendship, Moscow, Russia, 117198

Maksimova T.V.

Kafedra farmatsevticheskoĭ i toksikologicheskoĭ khimii FGBOU VPO "Rossiĭskiĭ universitet druzhby narodov", Moskva, Rossiia, 117198

Pleteneva T.V.

Kafedra obshcheĭ i klinicheskoĭ farmakologii i kafedra farmatsevticheskoĭ i toksikologicheskoĭ khimii Rossiĭskogo universiteta druzhby narodov

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