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Barsegian S.S.

Biuro sudebno-meditsinskoĭ ékspertizy Departamenta zdravookhraneniia Moskvy

Maksimova T.V.

Kafedra farmatsevticheskoĭ i toksikologicheskoĭ khimii FGBOU VPO "Rossiĭskiĭ universitet druzhby narodov", Moskva, Rossiia, 117198

Morozov Iu.E.

Baltiĭskiĭ federal'nyĭ universitet im. Immanuila Kanta, Kaliningrad

Pleteneva T.V.

Kafedra obshcheĭ i klinicheskoĭ farmakologii i kafedra farmatsevticheskoĭ i toksikologicheskoĭ khimii Rossiĭskogo universiteta druzhby narodov

Salomatin E.M.

FGBU "Rossiĭskiĭ tsentr sudebno-meditsinskoĭ ékspertizy" Minzdravsotsrazvitiia Rossii, Moskva

Tuchik E.S.

GBUZ "Biuro sudebno-meditsinskoĭ ékspertizy" Departamenta zdravookhraneniia Moskvy

The problems of expert evaluation of the results of forensic chemical investigations of clozapine in the biological material

Authors:

Barsegian S.S., Maksimova T.V., Morozov Iu.E., Pleteneva T.V., Salomatin E.M., Tuchik E.S.

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Journal: Forensic Medical Expertise. 2014;57(5): 40‑46

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THE PROBLEMS OF EXPERT EVALUATION OF THE RESULTS OF FORENSIC CHEMICAL INVESTIGATIONS OF CLOZAPINE IN THE BIOLOGICAL MATERIAL
THE PROBLEMS OF EXPERT EVALUATION OF THE RESULTS OF FORENSIC CHEMICAL INVESTIGATIONS OF CLOZAPINE IN THE BIOLOGICAL MATERIAL

To cite this article:

Barsegian SS, Maksimova TV, Morozov IuE, Pleteneva TV, Salomatin EM, Tuchik ES. The problems of expert evaluation of the results of forensic chemical investigations of clozapine in the biological material. Forensic Medical Expertise. 2014;57(5):40‑46. (In Russ.)

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The objective of the present review was to analyse the problems of expert evaluation of the results of forensic chemical investigations of clozapine in the biological material. Such an analysis is needed because many topical aspects of the quantitative evaluation of toxic clozapine concentrations remain unclear. The treatment with clozapine is associated with its accumulation in blood in concentrations up to 2 mg/l in the absence of any toxic effect allegedly due to the development of tolerability of this agent. In the tolerant patients the ratio of the main clozapine metabolite, norclozapine, to clozapine itself in the serum amounts to 0.6-0.9. This value falls down to 0.3-0.4 in case of acute intoxication. In the case of identification of other pharmaceutical products narcotic drugs together with clozapine their influence on the activity of enzymes responsible for clozapine biotransformation should be taken into consideration. The concomitant intake of clozapine and alcohol may be dangerous for the clozapine-intolerant subjects. It is concluded that the above observations must be borne in mind in the assessment of the results of forensic chemical analysis.

Keywords:

clozapine (leponex
azaleptin)
norclozapine
intolerance
clozapine intoxication

Authors:

Barsegian S.S.

Biuro sudebno-meditsinskoĭ ékspertizy Departamenta zdravookhraneniia Moskvy

Maksimova T.V.

Kafedra farmatsevticheskoĭ i toksikologicheskoĭ khimii FGBOU VPO "Rossiĭskiĭ universitet druzhby narodov", Moskva, Rossiia, 117198

Morozov Iu.E.

Baltiĭskiĭ federal'nyĭ universitet im. Immanuila Kanta, Kaliningrad

Pleteneva T.V.

Kafedra obshcheĭ i klinicheskoĭ farmakologii i kafedra farmatsevticheskoĭ i toksikologicheskoĭ khimii Rossiĭskogo universiteta druzhby narodov

Salomatin E.M.

FGBU "Rossiĭskiĭ tsentr sudebno-meditsinskoĭ ékspertizy" Minzdravsotsrazvitiia Rossii, Moskva

Tuchik E.S.

GBUZ "Biuro sudebno-meditsinskoĭ ékspertizy" Departamenta zdravookhraneniia Moskvy

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