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Kartashov V.A.

Kafedra farmatsii Maĭkopskogo gosudarstvennogo tekhnologicheskogo universiteta, Maĭkop, Rossiia, 385000

Chernova L.V.

Institute of Pharmacy of Sechenov First State Medical University, Moscow, Russia, Chair of Pharmaceutical Technology, Moscow, Russia

Determination of olanzapine in cadaveric blood

Authors:

Kartashov V.A., Chernova L.V.

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Journal: Forensic Medical Expertise. 2014;57(4): 40‑43

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Table of contents

DETERMINATION OF OLANZAPINE IN CADAVERIC BLOOD
DETERMINATION OF OLANZAPINE IN CADAVERIC BLOOD

To cite this article:

Kartashov VA, Chernova LV. Determination of olanzapine in cadaveric blood. Forensic Medical Expertise. 2014;57(4):40‑43. (In Russ.)

Подписка 2026 Судебно-медицинская экспертиза (Forensic Medical Expertise)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Recommended articles:
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Abstract:

The authors present the results of experimental isolation of olanzapine from the biological objects in conjunction with the detailed description of the method for olanzapine extraction from cadaveric blood with the use of one of the amphiphilic solvents (e.g. acetone), purification by solvent extraction, and TLC-screening. Olanzapine was quantitatively determined by UV-spectrophotometry following its chromatography and elution. It was shown that one-step extraction from cadaveric blood by the proposed method made it possible to detect 55% of the total olanzapine content. The method was validated in the studies of blood and liver from the laboratory animals (rats) and can be recommended for the investigation in a chemical toxicological laboratory.

Keywords:

olanzapine
biological objects
extraction
TLC-screening
UV-spectrophotometry

Authors:

Kartashov V.A.

Kafedra farmatsii Maĭkopskogo gosudarstvennogo tekhnologicheskogo universiteta, Maĭkop, Rossiia, 385000

Chernova L.V.

Institute of Pharmacy of Sechenov First State Medical University, Moscow, Russia, Chair of Pharmaceutical Technology, Moscow, Russia

Close metadata

References:

  1. Stephens B.G., Coleman D.E., Baselt R.C. Olansapine - Related Fatality. J Forens Sci 1998; 43: 6: 1252-1253.
  2. Robertson M.D., McMullin M.M. Olansapine concentrations in clinical serum and postmortem blood specimes - when does therapeutic become toxic? J Forens Sci 2000; 45: 2: 418-421.
  3. Jenkins A.J., Sarkoni K.M., Raaf H.N. Determination of olansapine in a postmortem case. J Anal Toxicol 1998; 22: 7: 605-609.
  4. Сhue P., Singer P. A review of olanzapine-associated toxicity and fatality in overdose. J Psychiat Neurosci 2003; 28: 4: 253-261.
  5. Elean A.A. Fatal overdose of olanzapine. Forens Sci Int 1998; 91: 3: 231-235.
  6. Kartashov V.A., Chernova L.V. Khimiko-toksikologicheskiy analiz. Metody issledovaniya. Tonkosloinaya khromatografiya [The chemical and toxicological analysis. The research methods. Thin-layer chromatography]. Maikop: Kachestvo 2011.
  7. Kartashov V.A. Izuchenie voprosov ekstraktsii lekarstvennykh veshchestv iz biologicheskogo materiala: Avtoref. dis. … d-ra pharm. nauk [The study on the problem: of extraction of medicinal substances from the biological materials: Synopsis of the thesis ... for d-r pharm. sci. degree]. Barnaul 1990.
  8. Chernova L.V. Izolirovanie, obnaruzhenie I opredelenie khlorprotiksena, aminazina, amitriptilina I imizina pri issledovanii biologicheskogo materiala: Avtoref. dis. … kand. pharm. Nauk [Isolation, detection, and identification of chlorprotiksen, aminazine, amitriptyline, and imizine during investigations of the biological material: Synopsis of the thesis ... for candidate pharm. sci. degree]. Pyatigorsk 1990.
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