The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Kovalev A.V.

Krasnojarskij filial FGBU «Gematologicheskij nauchnyj tsentr» Minzdrava Rossii

Tolmachev S.I.

FGBU "Rossiĭskiĭ tsentr sudebno-meditsinskoĭ ékspertizy" Minzdravsotsrazvitiia Rossii, Moskva

Mukovskiĭ L.A.

Laboratoriia toksikologii Instituta toksikologii FMBA Rossii, Sankt-Peterburg

Khrustaleva Iu.A.

Kafedra sudebnoĭ meditsiny Voenno-meditsinskoĭ akademii im. S.M. Kirova, Sankt-Peterburg

The biological activity of the irritant dibenz-[b,f]-[1,4]-oxazepine (substance CR) persisting during a long period at the environmental objects

Authors:

Kovalev A.V., Tolmachev S.I., Mukovskiĭ L.A., Khrustaleva Iu.A.

More about the authors

Journal: Forensic Medical Expertise. 2012;55(5): 38‑41

Read: 1676 times

Download PDF (RU)
Contact the author
Table of contents

THE BIOLOGICAL ACTIVITY OF THE IRRITANT DIBENZ-[B,F]-[1,4]-OXAZEPINE (SUBSTANCE CR) PERSISTING DURING A LONG PERIOD AT THE ENVIRONMENTAL OBJECTS
THE BIOLOGICAL ACTIVITY OF THE IRRITANT DIBENZ-[B,F]-[1,4]-OXAZEPINE (SUBSTANCE CR) PERSISTING DURING A LONG PERIOD AT THE ENVIRONMENTAL OBJECTS

To cite this article:

Kovalev AV, Tolmachev SI, Mukovskiĭ LA, Khrustaleva IuA. The biological activity of the irritant dibenz-[b,f]-[1,4]-oxazepine (substance CR) persisting during a long period at the environmental objects. Forensic Medical Expertise. 2012;55(5):38‑41. (In Russ.)

Подписка 2026 Судебно-медицинская экспертиза (Forensic Medical Expertise)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Abstract:

The objective of the present study was to determine the biological activity of the irritant dibenz-[B,F]-[1,4]-oxazepine (substance CR) contained in the environmental samples in case of their "closed" storage during different periods of time. The experiments were carried out using male and female rabbits of the Chinchilla strain with the initial body mass of 3000-4000 g. The animals were administered an aqueous alcoholic extract from the tissue samples of the rabbit eye coat as described in the "Methodological guidelines on the medico-biological assessment of the safety of personal protection devices". The results of experiments indicate that extracts from tissue samples elicit irritation in the eyes of the laboratory animals even after their storage as long as 600 days. This observation suggests that substance CR retains the ability to cause irritation during a prolonged period.

Keywords:

irritant
gaseous self-defense devices
dibenzoxazepine
biological activity

Authors:

Kovalev A.V.

Krasnojarskij filial FGBU «Gematologicheskij nauchnyj tsentr» Minzdrava Rossii

Tolmachev S.I.

FGBU "Rossiĭskiĭ tsentr sudebno-meditsinskoĭ ékspertizy" Minzdravsotsrazvitiia Rossii, Moskva

Mukovskiĭ L.A.

Laboratoriia toksikologii Instituta toksikologii FMBA Rossii, Sankt-Peterburg

Khrustaleva Iu.A.

Kafedra sudebnoĭ meditsiny Voenno-meditsinskoĭ akademii im. S.M. Kirova, Sankt-Peterburg

Close metadata

References:

  1. Tomilin V.V., Babakhanyan R.V., Mukovskii L.A. Gazovoe oruzhie - novaya problema sudebnoi toksikologii. Sud med ekspert 1995; 1: 8-10.
  2. Aleksandrov V.N., Emel'yanov V.I. Otravlyayushchie veshchestva: uchebnoe posobie. M: Voenizdat 1990; 202-225.
  3. Bandman L.A., Savateev N.V. Toksikologiya CR. Voen med zhurn 1977; 3: 84-86.
  4. Franke Z. Khimiya otravlyayushchikh veshchestv. Per. s nem. M: Iz-vo "Khimiya" 1973; 1: 65-108.
  5. Khimicheskii entsiklopedicheskii slovar'. Pod. red. A.I. Knunyantsa. M: Sovetskaya entsiklopediya 1983; 243.
  6. Prikaz Minzdravsotsrazvitiya Rossii ot 22 oktyabrya 2008 g. №583n "O razreshenii k primeneniyu slezotochivykh i razdrazhayushchikh veshchestv v sostave patronov k gazovomu oruzhiyu, mekhanicheskikh raspylitelei, aerozol'nykh i drugikh ustroistv grazhdanskogo oruzhiya samooborony".
  7. Mukovskii L.A., Babaina E.V., Kul'bitskii G.N., Khrustaleva Yu.A. Zagryaznenie okruzhayushchei sredy komponentami gazovogo oruzhiya. Rossiiskaya nauchnaya konferentsiya "Meditsinskie aspekty radiatsionnoi i khimicheskoi bezopasnosti": Materialy. SPb: VMA 2001; 86-87.
  8. Pozdeev V.N., Losenok S.A. Voennaya toksikologiya i meditsinskaya zashchita voisk i naseleniya ot radiatsionnykh i khimicheskikh porazhenii: uchebnoe posobie dlya studentov meditsinskikh vuzov. Kursk: KGMU 2004; 74-77.
  9. Zagryadskaya A.P., Lebedev S.I., Fedorovtsev A.L., Filatov V.Yu., Edelev N.S. Porazhayushchee deistvie gazovogo oruzhiya. Nizhegorodskii med zhurn 2000; 2: 103-106.
  10. Ballantyne B., Beswick F.W., Price-Thomas B. The presentation and management of individuals contaminated with solutions of dibenzoxazepine (CR). Med Sci Law 1973; 13: 265.
  11. Zapadnyuk I.P., Zapadnyuk V.I., Zakhariya E.A., Zapadnyuk B.V. Laboratornye zhivotnye. Razvedenie, soderzhanie, ispol'zovanie v eksperimente - Kiev: Vishcha shkola 1983; 195-223.
  12. Pravila provedeniya rabot s ispol'zovaniem eksperimental'nykh zhivotnykh (utverzhdeny prikazom MZ SSSR ot 12.08.77 №755 "O merakh po dal'neishemu sovershenstvovaniyu organizatsionnykh form raboty s ispol'zovaniem eksperimental'nykh zhivotnykh").
  13. Sanitarnye pravila po ustroistvu, oborudovaniyu i soderzhaniyu eksperimental'no-biologicheskikh klinik (vivariev) ot 6 aprelya 1973 g. №1045-73. MZ SSSR. M 1973.
  14. Natsional'nyi standart Rossiiskoi Federatsii. GOST R 53434 2009. Printsipy nadlezhashchei laboratornoi praktiki. M: Standartinform 2010; 28.
  15. Mediko-biologicheskie i khimiko-analiticheskie ispytaniya bez­opasnosti i effektivnosti gazovogo oruzhiya samooborony. Metodicheskie ukazaniya. Volgograd: NIIGTP 1998; 70.
  16. Spasskii A.S. Metodika otsenki razdrazhayushchego deistviya khimicheskikh veshchestv na perednii otdel glaza. Gig i san 1992; 3: 75-77.
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.