The biological activity of the irritant dibenz-[b,f]-[1,4]-oxazepine (substance CR) persisting during a long period at the environmental objects

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Kovalev A.V.

Krasnojarskij filial FGBU «Gematologicheskij nauchnyj tsentr» Minzdrava Rossii

Tolmachev S.I.

FGBU "Rossiĭskiĭ tsentr sudebno-meditsinskoĭ ékspertizy" Minzdravsotsrazvitiia Rossii, Moskva

Mukovskiĭ L.A.

Laboratoriia toksikologii Instituta toksikologii FMBA Rossii, Sankt-Peterburg

Khrustaleva Iu.A.

Kafedra sudebnoĭ meditsiny Voenno-meditsinskoĭ akademii im. S.M. Kirova, Sankt-Peterburg

The biological activity of the irritant dibenz-[b,f]-[1,4]-oxazepine (substance CR) persisting during a long period at the environmental objects

Authors:

Kovalev A.V., Tolmachev S.I., Mukovskiĭ L.A., Khrustaleva Iu.A.

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Journal: Forensic Medical Expertise. 2012;55(5): 38‑41

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To cite this article:

Kovalev AV, Tolmachev SI, Mukovskiĭ LA, Khrustaleva IuA. The biological activity of the irritant dibenz-[b,f]-[1,4]-oxazepine (substance CR) persisting during a long period at the environmental objects. Forensic Medical Expertise. 2012;55(5):38‑41. (In Russ.)

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The objective of the present study was to determine the biological activity of the irritant dibenz-[B,F]-[1,4]-oxazepine (substance CR) contained in the environmental samples in case of their "closed" storage during different periods of time. The experiments were carried out using male and female rabbits of the Chinchilla strain with the initial body mass of 3000-4000 g. The animals were administered an aqueous alcoholic extract from the tissue samples of the rabbit eye coat as described in the "Methodological guidelines on the medico-biological assessment of the safety of personal protection devices". The results of experiments indicate that extracts from tissue samples elicit irritation in the eyes of the laboratory animals even after their storage as long as 600 days. This observation suggests that substance CR retains the ability to cause irritation during a prolonged period.

Keywords:

irritant

gaseous self-defense devices

dibenzoxazepine

biological activity

Authors:

Kovalev A.V.

Krasnojarskij filial FGBU «Gematologicheskij nauchnyj tsentr» Minzdrava Rossii

Tolmachev S.I.

FGBU "Rossiĭskiĭ tsentr sudebno-meditsinskoĭ ékspertizy" Minzdravsotsrazvitiia Rossii, Moskva

Mukovskiĭ L.A.

Laboratoriia toksikologii Instituta toksikologii FMBA Rossii, Sankt-Peterburg

Khrustaleva Iu.A.

Kafedra sudebnoĭ meditsiny Voenno-meditsinskoĭ akademii im. S.M. Kirova, Sankt-Peterburg

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