Methods for the protection against counterfeit medications. Part 2. The assessment of interlot dispersion of the metoprolol succinate tablets fabricated by different manufacturers

Iakushev V.A.; Morozova M.A.; Elizarova T.E.; Fitilev S.B.; Pleteneva T.V.

doi:https://doi.org/

Iakushev V.A.

Kafedra obshcheĭ i klinicheskoĭ farmakologii i kafedra farmatsevticheskoĭ i toksikologicheskoĭ khimii Rossiĭskogo universiteta druzhby narodov

Morozova M.A.

Laboratoriia psikhofarmakologii Nauchnogo tsentra psikhicheskogo zdorov'ia RAMN, Moskva

Elizarova T.E.

OOO "KoAL Farmanaliz", Moskva

Fitilev S.B.

Kafedra obshcheĭ i klinicheskoĭ farmakologii i kafedra farmatsevticheskoĭ i toksikologicheskoĭ khimii Rossiĭskogo universiteta druzhby narodov

Pleteneva T.V.

Kafedra obshcheĭ i klinicheskoĭ farmakologii i kafedra farmatsevticheskoĭ i toksikologicheskoĭ khimii Rossiĭskogo universiteta druzhby narodov

Methods for the protection against counterfeit medications. Part 2. The assessment of interlot dispersion of the metoprolol succinate tablets fabricated by different manufacturers

Authors:

Iakushev V.A., Morozova M.A., Elizarova T.E., Fitilev S.B., Pleteneva T.V.

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Journal: Forensic Medical Expertise. 2012;55(5): 46‑48

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Iakushev VA, Morozova MA, Elizarova TE, Fitilev SB, Pleteneva TV. Methods for the protection against counterfeit medications. Part 2. The assessment of interlot dispersion of the metoprolol succinate tablets fabricated by different manufacturers. Forensic Medical Expertise. 2012;55(5):46‑48. (In Russ.)

Подписка 2026 Судебно-медицинская экспертиза (Forensic Medical Expertise)

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Abstract:

This paper reports the results of analysis of the metoprolol succinate tablets fabricated by two different manufacturers, Akrikhin (Russia) and AstraZeneka (Sweden) by near-IR spectroscopy in the combination with the chemometric processing of the data obtained (discriminative analysis). It is concluded that this method is applicable for the assessment of `interlot dispersion of the metoprolol succinate tablets.

Keywords:

near-IR spectroscopy

discriminative analysis

metoprolol succinate.

Authors:

Iakushev V.A.

Kafedra obshcheĭ i klinicheskoĭ farmakologii i kafedra farmatsevticheskoĭ i toksikologicheskoĭ khimii Rossiĭskogo universiteta druzhby narodov

Morozova M.A.

Laboratoriia psikhofarmakologii Nauchnogo tsentra psikhicheskogo zdorov'ia RAMN, Moskva

Elizarova T.E.

OOO "KoAL Farmanaliz", Moskva

Fitilev S.B.

Kafedra obshcheĭ i klinicheskoĭ farmakologii i kafedra farmatsevticheskoĭ i toksikologicheskoĭ khimii Rossiĭskogo universiteta druzhby narodov

Pleteneva T.V.

Kafedra obshcheĭ i klinicheskoĭ farmakologii i kafedra farmatsevticheskoĭ i toksikologicheskoĭ khimii Rossiĭskogo universiteta druzhby narodov

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