The aim of the study was to compare the precision of centric relation (CR) assessment by various methods using digital technologies. Material and methods. Determination of the CR was carried out in the clinic of prosthetic dentistry on patients with intact dentition using methods of bilateral manipulation, anterior jig, leaf gauge and device for intraoral recording of the gothic arch angle. Optical jaw impressions were obtained using the intraoral 3D scanner Trios (3Shape) and the CR registers were scanned using the laboratory scanner Prime (DOF). To evaluate the reproducibility of the CR, the computer program of 3D modeling Avantis (Russia) was used, which integrated the obtained optical impressions and digital copies of the CR registers. Results. None of the methods showed 100% accuracy in CR assessment. The most stable reproducibility of the position of the mandible in the CR relative to the first registration was determined by the method using an anterior jig (of our own design) and amounted to 0.119±0.012 mm, which is significantly less than using the methods of bilateral manipulation (0.225±0.028, p≤0.05) and a leaf gauge (0.207±0.02, p≤0.05). We observed a similar mean values of the reproduction accuracy when determining the CR by recording the Gothic arch angle (0,120±0,013, p≤0.05), which also has a significantly lower value (p≤0.05) compared to other methods for CR determining.