The purpose of the study was clinical and laboratory analysis of the remineralizing properties and clinical efficacy of the course application of the Sensodyne Rapid Relief therapeutic and prophylactic toothpaste for sensitive teeth with tin fluoride. The study involved 50 overwise healthy patients aged from 18 to 25 years diagnosed with a localized form of hyperesthesia of hard dental tissues and no signs of acute inflammation of periodontal tissues. After 7 days of clinical observation and daily use of the toothpaste the hygienic condition of the oral cavity in all patients improved: oral hygiene index was 1.02±0.2 units; gum inflammation index (PMA) — 8.0±1.5%; the absence of hyperesthesia was diagnosed (1 point, p≤0.05). Examination of patients after 14 and 28 days confirmed the absence of pain in 100%, the organoleptic properties of the toothpaste under investigation were also highly appreciated by the participants. A laboratory study showed that patients have an increase in the pH value of mixed saliva and a decrease in its buffer capacity by 13.4±2.25%, which contributes to a more effective remineralizing effect of calcium ions by calcium-binding proteins of mixed saliva. The concentration of fluoride ions in the saliva of patients of both groups increased by average rate of 34±0.5% per week. The combination of tin and fluoride is more effective than fluoride alone. The presence of tin ions causes a higher ability of fluorides to bind with calcium ions on the surface of the dentin and dentinal tubules, inhibits the process of demineralization, enhances the additive interaction of the ions forming the acid-resistant layer on the surface of the dentin and dentinal tubules, leading to a decrease in hyperesthesia of the teeth.