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Runova G.S.

Kafedra gospital'noĭ terapevticheskoĭ stomatologii, parodontologii, geriatricheskoĭ stomatologii Moskovskogo gosudarstven­nogo mediko-stomatologicheskogo universiteta

Kuznetsova L.V.

Federal'nyĭ tsentr serdtsa, krovi i éndokrinologii im. V.A. Almazova Minzdravsotsrazvitiia Rossii, Institut perinatologii i pediatrii, NKO reproduktsii i zdorov'ia zhenshchiny, Sankt-Peterburg

Morozova M.A.

Laboratoriia psikhofarmakologii Nauchnogo tsentra psikhicheskogo zdorov'ia RAMN, Moskva

Adzhieva A.G.

Moscow State University of Medicine and Dentistry named after A.I. Evdokimov, Moscow, Russia

Zairat’yants O.V.

A.I. Evdokimov Moscow State Medical Stomatological, Moscow, Russia, 127473

Malyshev I.Yu.

Department of pathological physiology of the Medical Faculty Moscow State University of Medicine and Dentistry named after A.I. Evdokimov Russian Ministry of Health, Moscow, Russia, Department of Periodontology of the Medical Faculty Moscow State University of Medicine and Dentistry named after A.I. Evdokimov Russian Ministry of Health, Moscow, Russia

Yanushevich O.O.

Evdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia

Growing of murine tooth in situ by homotopic transplantation of embryonic germ

Authors:

Runova G.S., Kuznetsova L.V., Morozova M.A., Adzhieva A.G., Zairat’yants O.V., Malyshev I.Yu., Yanushevich O.O.

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Journal: Stomatology. 2019;98(3): 12‑14

DOI: 10.17116/stomat20199803112

Read: 4133 times

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Table of contents

GROWING OF MURINE TOOTH IN SITU BY HOMOTOPIC TRANSPLANTATION OF EMBRYONIC GERM
GROWING OF MURINE TOOTH IN SITU BY HOMOTOPIC TRANSPLANTATION OF EMBRYONIC GERM

To cite this article:

Runova GS, Kuznetsova LV, Morozova MA, Adzhieva AG, Zairat’yants OV, Malyshev IYu, Yanushevich OO. Growing of murine tooth in situ by homotopic transplantation of embryonic germ. Stomatology. 2019;98(3):12‑14. (In Russ.)
https://doi.org/10.17116/stomat20199803112

Подписка 2026 Стоматология (Stomatology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Tissue engineering offers to restore the lost tooth using a biological analogue grown from the tooth germ. These technologies provide long-term cultivation of the germ in bioreactor in vitro. The subsequent transfer and growth of the in vitro grown tooth in the jaw is hampered by difficulty of integration of the new tooth with the host tissue. We suggested that growing tooth by homotopic transplantation in situ, that is, immediately in the jaw passing the in vitro stage will help to solve these problems. The aim of the work was to test the hypothesis. The principal possibility of transfer of the tooth germ directly into the jaw and cultivation in situ eliminating the stage in vitro is shown. The results showed a good integration of the grown teeth with the jaw without signs of inflammation and with the appearance of blood vessels in the pulp. At the same time, the results also showed the necessity to improve the preparation of tooth germs for transplantation and surgical procedures.

Authors:

Runova G.S.

Kafedra gospital'noĭ terapevticheskoĭ stomatologii, parodontologii, geriatricheskoĭ stomatologii Moskovskogo gosudarstven­nogo mediko-stomatologicheskogo universiteta

Kuznetsova L.V.

Federal'nyĭ tsentr serdtsa, krovi i éndokrinologii im. V.A. Almazova Minzdravsotsrazvitiia Rossii, Institut perinatologii i pediatrii, NKO reproduktsii i zdorov'ia zhenshchiny, Sankt-Peterburg

Morozova M.A.

Laboratoriia psikhofarmakologii Nauchnogo tsentra psikhicheskogo zdorov'ia RAMN, Moskva

Adzhieva A.G.

Moscow State University of Medicine and Dentistry named after A.I. Evdokimov, Moscow, Russia

Zairat’yants O.V.

A.I. Evdokimov Moscow State Medical Stomatological, Moscow, Russia, 127473

Malyshev I.Yu.

Department of pathological physiology of the Medical Faculty Moscow State University of Medicine and Dentistry named after A.I. Evdokimov Russian Ministry of Health, Moscow, Russia, Department of Periodontology of the Medical Faculty Moscow State University of Medicine and Dentistry named after A.I. Evdokimov Russian Ministry of Health, Moscow, Russia

Yanushevich O.O.

Evdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia

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References:

  1. Jamal HA. Tooth organ bioengineering: cell sources and innovative approaches. Dent J. 2016;4(18):1-12. https://doi.org/10.3390/dj4020018
  2. Hirayama M, Oshima M, Tsuji T. Development and prospects of organ replacement regenerative therapy. Cornea. 2013;32(1):13-21. https://doi.org/10.1097/ICO.0b013e3182a18e6c
  3. Hashmi B, Zarzar LD, Mammoto T, Mammoto A, Jiang A, Aizenberg J, Ingber DE. Developmentally-inspired shrink-wrap polymers for mechanical induction of tissue differentiation. Advanced Materials. 2014;26(20):3253-3257. https://doi.org/10.1002/adma.201304995
  4. Monteiro N, Yelick PC. Advances and perspectives in tooth tissue engineering. Journal of Tissue Engineering and Regenerative Medicine. 2016. https://doi.org/10.1002/term.2134
  5. Tooth regeneration. In: methods in molecular biology. Clifton N.J. Vol 1597. 2017;97-116. https://doi.org/10.1007/978-1-4939-6949-4_8
  6. Jussila M, Thesleff I. Signaling networks regulating tooth organogenesis and regeneration, and the specification of dental mesenchymal and epithelial cell lineages. Cold Spring Harbor Perspectives in Biology. 2012;4(4):a008425. https://doi.org/10.1101/cshperspect.a008425
  7. Otsu K, Kumikami-Sakano M, Fujiwara N, Kikuchi K, Keller L, Lesot H, Harada H. Stem cell sources for tooth regeneration: current status and future prospects. Frontiers in Physiology. 2014;5:36. https://doi.org/10.3389/fphys.2014.00036
  8. Sonoyama W, Liu Y, Yamaza T. Characterization of the apical papilla and its residing stem cells from human immature permanent teeth: a pilot study. Journal of Endodontics. 2008;34(2):166-171. https://doi.org/10.1016/j.joen.2007.11.021
  9. Otsu K, Kishigami R, Oikawa-Sasaki A. Differentiation of iPS cells into dental mesenchymal cells. Stem Cells and Development. 2012;21(7):1156-1164. https://doi.org/10.1089/scd.2011.0210
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