Subjective, functional and microbiological parameters of the oral cavity in gastroesophageal reflux patients with acidic and subacidic refluctant

The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Search result: 0

Lukina G.I.

A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia, Moscow, Russia

Krikheli N.I.

Moskovskiĭ gosudarstvennyĭ mediko-stomatologicheskiĭ universitet

Ivannikova A.V.

GBOU VPO «Moskovskij gosudarstvennyj mediko-stomatologicheskij universitet im. A.I. Evdokimova» Minzdrava Rossii, Rossija

Gioeva Iu.A.

Moskovskiĭ mediko-stomatologicheskiĭ universitet

Subjective, functional and microbiological parameters of the oral cavity in gastroesophageal reflux patients with acidic and subacidic refluctant

Authors:

Lukina G.I., Krikheli N.I., Ivannikova A.V., Gioeva Iu.A.

More about the authors

Journal: Stomatology. 2018;97(3): 23‑29

DOI: 10.17116/stomat201897323

Views: 849

Downloaded: 11

Download PDF (RU)

Contact the author

Table of contents

To cite this article:

Lukina GI, Krikheli NI, Ivannikova AV, Gioeva IuA. Subjective, functional and microbiological parameters of the oral cavity in gastroesophageal reflux patients with acidic and subacidic refluctant. Stomatology. 2018;97(3):23‑29. (In Russ.)
https://doi.org/10.17116/stomat201897323

Подписка 2025-2 (Stomatology)

Close metadata

Recommended articles:

Features of the oral microbiota in patients with type II diabetes in the background of dental implantation. Russian Journal of Stomatology. 2024;(2):21-26

The aim of the study was to compare dental and periodontal status, oral hygiene, salivation rate, functional parameters of saliva and oral microbiota composition in patients with gastroesophageal reflux disease (GERD) with acidic and subacidic refluctant. The study comprised 69 participants divided in 3 groups: 22 healthy volunteers (controls) and 2 main groups: 25 GERD patients with acidic (group 2) and 22 patients with subacidic refluctant (group 3). Poor dental and periodontal condition was revealed in group 3 patients probably because of aggressive intestinal content reflux in the oral cavity resulting in higher PMA an saliva pH values, Escherichia coli species in oral microbiota and low buffer capacity of saliva. The results show that GERD may be suspected due to oral manifestations thus promoting it’s prompt treatment.

Keywords:

gastroesophageal reflux disease (GERD)

24-hour multichannel intraesophageal impedance monitoring

acidic refluctant

subacidic refluctant

oral hygiene

periodontal status

salivation rate

saliva pH

buffer capacity of saliva

oral microbiota

Authors:

Lukina G.I.

A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia, Moscow, Russia

Krikheli N.I.

Moskovskiĭ gosudarstvennyĭ mediko-stomatologicheskiĭ universitet

Ivannikova A.V.

GBOU VPO «Moskovskij gosudarstvennyj mediko-stomatologicheskij universitet im. A.I. Evdokimova» Minzdrava Rossii, Rossija

Gioeva Iu.A.

Moskovskiĭ mediko-stomatologicheskiĭ universitet

List of references:

Fadeenko GD. Vnepishhevodnye projavlenija gastrojezofageal’noj refljuksnoj bolezni. (In Russ.) http://www.gastroscan.ru/literature/authors/454
Jurenev GL, Samsonov AA, Jureneva-Thorzhevskaja TV i dr. Vlijanie psihokorrekcii na klinicheskij status i kachestvo zhizni komorbidnyh pacientov s GJeRB i bronhial’noj astmoj. Farmateka. Gastrojenterologija. 2014;14:40-46. (In Russ.)
Kahrilas PJ, McColl K, Fox M, ORourke L, Sifrim D, Smout AJ, et al. The acid pocket: a target for treatment in reflux disease? Am J Gastroenterol. 2013;108:1058-1064.
Mönkemüller K, Wex T, Kuester D, Fry LC, Kandulski A, Kropf S, Roessner A, Malfertheiner P. Role of tight junction proteins in gastroesophageal reflux disease. BMC Gastroenterol. 2012;12:128.
Rohof WO, Bennik RJ, de Ruigh AA, Hirsch DP, Zwinderman AH, Boeckxstaens GE. Effect of azithromycin on acid reflux, hiatus hernia and proximal acid pocket in the postprandial period. Gut. 2012.
Seo AY, Shin CM, Kim N, Yoon H, Park YS, Lee DH. Correlation between hypersensitivity induced by esophageal acid infusion and the baseline impedance level in patients with suspected gastroesophageal reflux. J Gastroenterol. 2014;50:735-743.
Weijenborg PW, Smout AJ, Verseijden C, van Veen HA, Verheij J, de Jonge WJ, Bredenoord AJ. Hypersensitivity to acid is associated with impaired esophageal mucosal integrity in patients with gastroesophageal reflux disease with and without esophagitis. Am J Physiol. 2014;307:323-329.
Woodland P, Sifrim D. Managent of gastro-oesophageal reflux disease symptoms that do not respond to proton pump inhibitors. Curr Opin Gastroenterol. 2013;29:4:431-436.
Yerian L, Fiocca R, Mastracci L, Riddell R, Vieth M, Sharma P, Franzen S, Fernstrom P, Ruth M. Refinement and reproducibility of histologic criteria for the assessment of microscopic lesions in patients with gastroesophageal reflux disease: the Esohisto Project. Dig Dis Sci. 2011;56:2656-2665.
Andreev DN, Kucherjavyj YuA. Perspektivy lechenija gastrojezofageal’noj refljuksnoj bolezni. Consilium medicum. 2013;2:9-14. (In Russ.)
Ahmedhanov IA. Ocenka urovnja salivacii i sostojanija polosti rta pri patologii verhnih otdelov pishhevaritel’nogo trakta: Dis... kand. med. nauk. M. 2013. (In Russ.)
Dzhulaj GS, Sekareva EV, Chervinec VM. i dr. Gastrojezofagealnaja refluksnaja bolezn, associirovannaja s duodenogastrojezofagealnym refljuksom, u bolnyh s biliarnoj patologiej: osobennosti techenija I mikrobnogo biocenoza jezofagogastroduodenalnoj zony. Terapevt arh. 2014;2:17-22. (In Russ.)
Ivanova OI, Minushkin ON. Antacidy v sovremennoj terapii kislotozavisimyh zabolevanij. Medicinskij sovet. 2015;13:30-36. (In Russ.)
Kajbysheva VO, Storonova OA, Truhmanov AS i dr. Vozmozhnosti vnutripishhevodnoj rN-impedansometrii v diagnostike GJeRB. Ros zhurn gastrojenterol, gepatol, koloproktol. 2013;23:2:4-16. (In Russ.)
Kurilovich S, Chekalina E, Belkovec A, Shherbakova L. Antisekretornaja aktivnost’ jezomeprazola (JemaneraR) u pacientov s kislotozavisimymi zabolevanijami. Vrach. 2015;8:35-40. (In Russ.)
BjÃ¶rkman EV, Edebo A, Oltean M, Casselbrant A. Esophageal barrier function and tight junction expression in healthy subjects and patients with gastroesophageal reflux disease: functionality of esophageal mucosa exposed to bile salt and trypsin in vitro. Scand J Gastroenterol. 2013;48:1118-1126.
Oshima T, Koseki J, Chen X, Matsumoto T, Miwa H. Acid modulates the squamous epithelial barrier function by modulating the localization of claudins in the superficial layers. Lab Invest. 2012;92:22-31.
Vaezi MF. Ambulatory Monitoring for Gastroesophageal Reflux Disease: Where Do We Stand? Clin Gastroenterol Hepatol. 2014;5:19-23.
Lukina GI. Morfofunkcional’nye osobennosti slizistoj obolochki polosti rta u bol’nyh s zabolevanijami organov pishhevarenija: Dias. … d-ra med. nauk. M. 2011. (In Russ.)
Maev IV, Iurenev GL, Burkov SG. Mnogolikaia GERB: problemy i resheniia. M.: GEOTAR-Media; 2015. (In Russ.)
Spechler RF. Souza. S. Barrettâ€™s esophagus. J N Engl J Med. 2014;371:836-845.
Chiu CTI, Hsu CM, Wang CC, Chang JJ, Sung CM, Lin CJ, Chen LW, Su MY, Chen TH. Randomised clinical trial: sodium alginate oral suspension is non-inferior to omeprazole in the treatment of patients with nonerosive gastroesophageal disease. Aliment Pharmacol Ther. 2013;38(9):1054-1064.
De Ruigh A, Roman S, Chen J, Pandolfino J, Cahrillas PJ. Gaviscon Double Action Liquid (antacid & alginate) is more effective than antacid in controlling post-prandial oesophageal acid exposure in GERD patients: a double-blind crossover study. Aliment Pharmacol Ther. 2014;40(5):531-537.
Pardon N, Vanheel H, Toth J, et al. Effect of the perfusion of acidic and weakly acidic solutions on mucosal integrity and expression of cell-to-cell adhesion proteins in humans. Neurogastroenterol. Motil. 2014;26:36-37.

Close metadata

Log in to the site using your account in one of the services

Registration

Last Name

Name

Middle Name

E-mail

Phone

Address

Country

Zip

City

Region

Street

Home

Apartmen

Legal entity name

ИНН

КПП

Password

Password

Repeat password

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.