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Ivina A.A.

Kafedra patologicheskoĭ anatomii meditsinskogo fakul'teta FGBOU VPO "Rossiĭskiĭ universitet druzhby narodov"

Semkin V.A.

Otdelenie khirurgicheskoĭ stomatologii FGBU "Tsentral'nyĭ nauchno-issledovatel'skiĭ institut stomatologii i cheliustno-litsevoĭ khirurgii" Minzdrava RF, Moskva

Babichenko I.I.

Russian University of People’s Friendship, Moscow, Russia, 117198

The role of Sonic Hedgehog signaling pathway in the development of oral squamous cell carcinoma

Authors:

Ivina A.A., Semkin V.A., Babichenko I.I.

More about the authors

Journal: Stomatology. 2018;97(3): 4‑6

DOI: 10.17116/stomat20189734

Read: 2205 times

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Table of contents

THE ROLE OF SONIC HEDGEHOG SIGNALING PATHWAY IN THE DEVELOPMENT OF ORAL SQUAMOUS CELL CARCINOMA
THE ROLE OF SONIC HEDGEHOG SIGNALING PATHWAY IN THE DEVELOPMENT OF ORAL SQUAMOUS CELL CARCINOMA

To cite this article:

Ivina AA, Semkin VA, Babichenko II. The role of Sonic Hedgehog signaling pathway in the development of oral squamous cell carcinoma. Stomatology. 2018;97(3):4‑6. (In Russ.)
https://doi.org/10.17116/stomat20189734

Подписка 2026 Стоматология (Stomatology)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

The research of the Sonic Hedgehog signaling pathway activity was carried out on biopsy specimens of 43 patients with oral hyperplasia, squamous intraepithelial neoplasia and oral squamous cell carcinoma. Tissue antigens were determined using a mouse monoclonal antibody to Ki-67 protein and rabbit monoclonal antibody to Gli-1 protein. In squamous intraepithelial neoplasia and oral squamous cell carcinoma specimens Gli-1 was detected in the cytoplasm of cells only. The correlation was found between the proliferative activity of epithelial cells and Gli-1 distribution. Protein Gli-1 can be used for early diagnosis of malignant transformation of oral stratified squamous epithelium.

Keywords:

immunohistochemistry
squamous cell carcinoma
Ki-67
Sonic Hedgehog
Gli-1

Authors:

Ivina A.A.

Kafedra patologicheskoĭ anatomii meditsinskogo fakul'teta FGBOU VPO "Rossiĭskiĭ universitet druzhby narodov"

Semkin V.A.

Otdelenie khirurgicheskoĭ stomatologii FGBU "Tsentral'nyĭ nauchno-issledovatel'skiĭ institut stomatologii i cheliustno-litsevoĭ khirurgii" Minzdrava RF, Moskva

Babichenko I.I.

Russian University of People’s Friendship, Moscow, Russia, 117198

Close metadata

References:

  1. Paluszczak J, et al. Prognostic significance of the methylation of Wnt pathway antagonists — CXXC4, DACT2, and the inhibitors of sonic hedgehog signaling—ZIC1, ZIC4, and HHIP in head and neck squamous cell carcinomas. Clin Oral Invest. 2017;21:1777-1178. https://doi.org/10.1007/s00784-016-1946-5
  2. Ivina AA, Semkin VA, Babichenko II. Immunohistochemical criteria for the differential diagnosis squamous epithelium changes in pyogenic granuloma and squamous cell carcinoma of the oral mucosa. Stomatologiia. 2017;96(2):33-35. (In Russ.) https://doi.org/10.17116/stomat201796233-35
  3. Wu F, et al. Role of GLI1 and NDRG1 in Increased Resistance to Apoptosis Induction. J Environ Pathol Toxicol Oncol. 2015;34(3):213-225.
  4. Ivina AA, Semkin VA, Babichenko II. Proteins Ki-67 and GLUT1 in estimation of oral malignant transformation. Arkhiv patologii. 2016;78(5):15-19. (In Russ.) https://doi.org/10.17116/patol201678515-19
  5. Ivina AA, Semkin VA, Babichenko II. Morphological basis of epithelial-mesenchymal transition of oral neoplastic epithelium. Stomatologiia. 2017;96(5). (In Russ.)
  6. Rabinovich OF, Ivina AA, Guseva AV, Babichenko II. Immunomorphology of oral lichen planus. Stomatologiia. 2016;95(2): 4-7. (In Russ.) https://doi.org/10.17116/stomat20169524-7
  7. Paluszczak J, et al. Frequent hypermethylation of WNT pathway genes in laryngeal squamous cell carcinomas. J Oral Pathol Med. 2014;43(9):652-657. https://doi.org/10.1111/jop.12178
  8. Wang YF, et al. Expression of hedgehog signaling molecules as a prognostic indicator of oral squamous cell carcinoma. HEAD & NECK. 2012;34(11):1556-1561. https://doi.org/10.1002/hed.21958
  9. Fan HX, et al. Sonic hedgehog signaling may promote invasion and metastasis of oral squamous cell carcinoma by activating MMP-9 and E-cadherin expression. Med Oncol. 2014;31:41. https://doi.org/10.1007/s12032-014-0041-5
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