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Petrukhina N.B.

Kafedra stomatologii FPPOV GBOU VPO "Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova" Minzdrava RF

Zorina O.A.

GBOU VPO "Pervyĭ MGMU imeni I.M. Sechenova"

Chikh E.V.

Kafedra klinicheskoĭ farmakologii i propedevtiki vnutrennikh bolezneĭ GBOU VPO "Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova"

Kartysheva E.V.

I.M. Sechenov First Moscow State Medical University, Moscow, Russia

Microbiocenosis of subgingival biofilm and intestinal content in chronic periodontal disease in patients with metabolic syndrome

Authors:

Petrukhina N.B., Zorina O.A., Chikh E.V., Kartysheva E.V.

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Journal: Stomatology. 2017;96(4): 11‑19

DOI: 10.17116/stomat201796411-19

Read: 1949 times

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Table of contents

MICROBIOCENOSIS OF SUBGINGIVAL BIOFILM AND INTESTINAL CONTENT IN CHRONIC PERIODONTAL DISEASE IN PATIENTS WITH METABOLIC SYNDROME
MICROBIOCENOSIS OF SUBGINGIVAL BIOFILM AND INTESTINAL CONTENT IN CHRONIC PERIODONTAL DISEASE IN PATIENTS WITH METABOLIC SYNDROME

To cite this article:

Petrukhina NB, Zorina OA, Chikh EV, Kartysheva EV. Microbiocenosis of subgingival biofilm and intestinal content in chronic periodontal disease in patients with metabolic syndrome. Stomatology. 2017;96(4):11‑19. (In Russ.)
https://doi.org/10.17116/stomat201796411-19

Подписка 2026 Стоматология (Stomatology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

The aim of the study was to assess correlations of subgingival biofilm and intestinal microbiota in patients with chronic periodontal disease (CPD) and metabolic syndrome (MS). The study included 80 patients divided in 2 groups: 40 healthy individuals with no signs of periodontal disease and 40 patients with CPD and MS. Oral and intestinal microbial consortia compositions were revealed using deep sequencing libraries of 16S rDNA. The study showed than the qualitative composition of the intestinal microbiome in patients with CPD differ significantly from the microbiome of controls. Real-time PCR of subgingival microflora in CPD patients revealed high content of P. gingivalis, T. forsythia and T. denticola, while in intestinal microbiome dominated representatives of Enterobacteriaceae and Eubacteriaceae families with signs of intestinal dysbiosis mostly associated with the decrease of protective species.

Keywords:

periodontal disease
metabolic syndrome
dysbiosis
PCR
NGS sequencing

Authors:

Petrukhina N.B.

Kafedra stomatologii FPPOV GBOU VPO "Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova" Minzdrava RF

Zorina O.A.

GBOU VPO "Pervyĭ MGMU imeni I.M. Sechenova"

Chikh E.V.

Kafedra klinicheskoĭ farmakologii i propedevtiki vnutrennikh bolezneĭ GBOU VPO "Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova"

Kartysheva E.V.

I.M. Sechenov First Moscow State Medical University, Moscow, Russia

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References:

  1. Akimova EV, Kayumov AD, Gakova EI, et al. Population characteristics of the metabolic syndrome in the open male population. Cardiology. 2014;6:58-61. (In Russ.).
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  3. Vedeshina EG, Babichev SA. Correction microbiocenosis oral cavity in patients with periodontitis. Kuban Research Medical Gazette. 2012;1:18-22. (In Russ.).
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  7. Shilov AM, Zorina OA, Petrukhina NB. Disbiotsenoz intestine, periodontitis and associated metabolic cardiovascular disease. Farmateka. 2013;14:85-91. (In Russ.).
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  9. Hansen AK, Hansen CH, Krych L, Nielsen DS. Impact of the gut microbiota on rodent models of human disease. World Journal Gastroenterol. 2014;20(47):17727-17736.
  10. International Diabetes Federation. Global IDF/ISPAD guideline for diabetes in childhood and adolescence. Brussels: IDF. 2011;130.
  11. Kaye EK, Chen N, Cabral HJ, et al. Metabolic Syndrome and Periodontal Disease Progression in Men. Journal Dental Research. 2016. pii: 0022034516641053
  12. Kim J, Amar S. Periodontal disease and systemic conditions: a bidirectional relationship. Odontology. 2006;94:10-21.
  13. Kuo LC, Polson AM, Kang T. Associations between periodontal diseases and systemic diseases: a review of the inter — relationships and interactions with diabetes, respiratory diseases, cardiovascular diseases and osteoporosis. Public Health. 2008;122:417-433.
  14. Socranky SS, Haffajee AD, Cugini MA, et al. Microbial complexes in subgingival plaque. J Clin Periodontol. 1998;25:134-144.
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