The rationale for the choice of local anesthesia in teeth with mild to moderate periodontal disease was formulated based on a comparative analysis of the effectiveness and safety of different local anesthesia methods with 4% articaine. Effectiveness of anesthesia was assessed using objective values of electric study of pulp sensitivity and registration of microcirculation in dental pulp. Safety analysis was based on changes in periodontal tissues microcirculation assessed by laser Doppler flowmetry, as well as of central hemodynamics rates.