In this study, the efficacy of intraseptal anesthesia (ISA) with the use of a 4% articaine-based anesthetic containing adrenalin (1: 200,000) was tudied in 70 children aged from 6 to 12 years and in 255 adult patients aged between 18 and 50 years. All the patients were treated for caries and its complications in the absence of apparent concomitant pathology. The efficacy of ISA in the treatment of uncomplicated caries on the permanent mandibular molars in children was estimated at 90%. In adults undergoing the treatment of maxillary teeth hard tissues and depulping, the efficacy of anesthesia was 85% and 78% respectively. In case of tissue preparation for the treatment of median caries on the surface of the mandibular teeth the efficacy was 83%, for the treatment of deep caries 65%, and for depulping 60%. The duration of any intervention did not exceed 15-17 minutes.