Mechanisms underlying formation of stress-related immunodeficiency associated with reconstructive facial surgery in children with congenital and acquired deformations of the maxillofacial region

Savchenko Z.I.; Topol'nitskiĭ O.Z.; Nikolaev A.P.; Evstifeeva O.V.

doi:https://doi.org/

Savchenko Z.I.

Kafedra detskoĭ khirurgicheskoĭ stomatologii i cheliustno-litsevoĭ khirurgii Moskovskogo gosudarstvennogo mediko-stomatologicheskogo universiteta

Topol'nitskiĭ O.Z.

Moskovskiĭ gosudarstvennyĭ mediko-stomatologicheskiĭ universitet

Nikolaev A.P.

N.V. Sklifosovskiy Institute for Emergency Care, Moscow Health Department;
Institute of Pulmonology, Federal Medical and Biological Agency of Russia, Moscow, Russia

Evstifeeva O.V.

Kafedra detskoĭ khirurgicheskoĭ stomatologii i cheliustno-litsevoĭ khirurgii Moskovskogo gosudarstvennogo mediko-stomatologicheskogo universiteta

Mechanisms underlying formation of stress-related immunodeficiency associated with reconstructive facial surgery in children with congenital and acquired deformations of the maxillofacial region

Authors:

Savchenko Z.I., Topol'nitskiĭ O.Z., Nikolaev A.P., Evstifeeva O.V.

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Journal: Russian Journal of Stomatology. 2011;4(2): 37‑42

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Savchenko ZI, Topol'nitskiĭ OZ, Nikolaev AP, Evstifeeva OV. Mechanisms underlying formation of stress-related immunodeficiency associated with reconstructive facial surgery in children with congenital and acquired deformations of the maxillofacial region. Russian Journal of Stomatology. 2011;4(2):37‑42. (In Russ.)

Подписка 2026 Российская стоматология (Russian Journal of Stomatology)

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Abstract:

This study has demonstrated the development of immunodeficiency related to the stress associated with reconstructive facial surgery in children with deformations of the maxillofacial region. Formation of immune deficiency was shown to be due to blockade of the stress-limiting system. Hence, the necessity of differential immune correction therapy in the postoperative period for reducing glucocorticoid-induced immunosuppression.

Keywords:

stress-related immunodeficiency

glucocorticoid-induced immunosuppression

stress-mediating system

stress-limiting system

immune correction therapy

Authors:

Savchenko Z.I.

Kafedra detskoĭ khirurgicheskoĭ stomatologii i cheliustno-litsevoĭ khirurgii Moskovskogo gosudarstvennogo mediko-stomatologicheskogo universiteta

Topol'nitskiĭ O.Z.

Moskovskiĭ gosudarstvennyĭ mediko-stomatologicheskiĭ universitet

Nikolaev A.P.

N.V. Sklifosovskiy Institute for Emergency Care, Moscow Health Department;
Institute of Pulmonology, Federal Medical and Biological Agency of Russia, Moscow, Russia

Evstifeeva O.V.

Kafedra detskoĭ khirurgicheskoĭ stomatologii i cheliustno-litsevoĭ khirurgii Moskovskogo gosudarstvennogo mediko-stomatologicheskogo universiteta

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References:

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