The significance of nasal respiration for the establishment of nasal mucosa structures

Piskunov G.Z.; Kartashkina N.L.; Kuzmin E.A.; Pokidova K.S.; Abramenko M.A.; Pyavchenko G.A.; Nikolenko V.N.

doi:https://doi.org/10.17116/rosrino202432041275

Piskunov G.Z.

Russian Medical Academy of Continuous Professional Education

ORCID: 0000-0003-2223-4812

Kartashkina N.L.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

ORCID: 0000-0003-4648-9027

Kuzmin E.A.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

ORCID: 0000-0003-4098-1125

Pokidova K.S.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

ORCID: 0009-0000-0323-7669

Abramenko M.A.

Kursk State Medical University

Pyavchenko G.A.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

ORCID: 0000-0001-7782-3468

Nikolenko V.N.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

ORCID: 0000-0001-9532-9957

The significance of nasal respiration for the establishment of nasal mucosa structures

Authors:

Piskunov G.Z., Kartashkina N.L., Kuzmin E.A., Pokidova K.S., Abramenko M.A., Pyavchenko G.A., Nikolenko V.N.

More about the authors

Journal: Russian Rhinology. 2024;32(4): 275‑282

DOI: 10.17116/rosrino202432041275

Read: 420 times

Contact the author

Table of contents

To cite this article:

Piskunov GZ, Kartashkina NL, Kuzmin EA, Pokidova KS, Abramenko MA, Pyavchenko GA, Nikolenko VN. The significance of nasal respiration for the establishment of nasal mucosa structures. Russian Rhinology. 2024;32(4):275‑282. (In Russ.)
https://doi.org/10.17116/rosrino202432041275

Подписка 2026 Российская ринология (Russian Rhinology)

Использование инфографики авторами научных работ

Abstract:

The nasal cavity, the primary segment of the respiratory tract, is a powerful protective barrier. The air passing the nasal cavity influences its mucous membrane as a physical factor. Still, the impact of inhaled airflows on the development of the nasal mucosa remains understudied.

OBJECTIVE

Assessment of the significance of the airflow influence on the nasal mucosa’s morphological structure during the early stages of the organism’s life.

MATERIAL AND METHODS

The experiment involved five 1-month-old Pannon rabbits subjected to unilateral nasal obstruction by suturing one nostril. The rabbits were subjected to computed tomography of the skull and lungs at 6, 9, and 12 months to monitor the development of the maxillary sinuses and lungs. The animals were removed from the experiment 12 months after its initiation. Then, mucosal regions were histologically analyzed on the side of obstruction and the intact (control) side.

RESULTS

Desquamation of the ciliated epithelium, mucous membrane sclerosis and hyalinosis, vascular bed reduction, gland hyperplasia with the formation of microcysts, gland atrophy, and foci of chronic inflammation were found on the side of the obstructed nasal breathing in the nasal mucosa of rabbits. The maxillary sinus epithelium on that side exhibited an irregular structure, with the basement membrane disruption. On the normal breathing side, the mucous membrane structure was consistent with physiological norms.

CONCLUSION

The study findings demonstrate the significant role of nasal breathing in establishing nasal mucosa structures.

Keywords:

mucous membrane of the nasal cavity and paranasal sinuses

air flow

formation of mucous membrane structures depending on the airflow

Authors:

Piskunov G.Z.

Russian Medical Academy of Continuous Professional Education

ORCID: 0000-0003-2223-4812

Kartashkina N.L.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

ORCID: 0000-0003-4648-9027

Kuzmin E.A.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

ORCID: 0000-0003-4098-1125

Pokidova K.S.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

ORCID: 0009-0000-0323-7669

Abramenko M.A.

Kursk State Medical University

Pyavchenko G.A.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

ORCID: 0000-0001-7782-3468

Nikolenko V.N.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

ORCID: 0000-0001-9532-9957

Received:

30.09.2024

Accepted:

01.10.2024

Close metadata

References:

Piskunov GZ, Piskunov SZ. Klinicheskaya rinologiya. Tret’e izdanie; Moskva: MIA; 2017. (In Russ.).
Piskunov SZ, Dolzhikov AA, Mezenceva OYu. Morfofunkcional’nye osobennosti slizistoj obolochki polosti nosa, razvivayushchiesya pri iskrivlenii nosovoj peregorodki. Rossijskaya otorinolaringologiya. 2004;(2):90-92. (In Russ.).
Mezenceva OYu, Dolzhikov AA, Piskunov VS. Morfologicheskie i morfometricheskie izmeneniya slizistoj obolochki polosti nosa pri iskrivlenii peregorodki. Russian Rhinology. 2005;(2):31. (In Russ.).
Piskunov VS. Narushenie aerodinamiki v polosti nosa — odna iz prichin ostrogo i hronicheskogo sinusita. Sbornik materialov, T. 1. Mediko-biologicheskie aspekty mul’tifaktoronoj patologii. Kursk; 2006. (In Russ.).
Piskunov SZ. Nos i zdorov’e. Kursk; 2001. (In Russ.).
Evseeva VV. Sostoyanie mukociliarnogo klirensa v zavisimosti ot polozheniya peregorodki nosa. Russian Rhinology. 2003;(2):21. (In Russ.).
Evseeva VV. Respiratornaya funkciya i nosovoj cikl pri iskrivlenii peregorodki nosa. Rossijskaya rinologiya. 2004;(2):8-10. (In Russ.).
Kumar L, Belaldavar BP, Bannur H. Influence of Deviated Nasal Septum on Nasal Epithelium: An Analysis. Head Neck Pathol. 2017 Dec;11(4):501-505. https://doi.org/10.1007/s12105-017-0819-9
Jang YJ, Myong NH, Park KH, Koo TW, Kim HG. Mucociliary transport and histologic characteristics of the mucosa of deviated nasal septum. Arch Otolaryngol Head Neck Surg. 2002 Apr;128(4):421-424. https://doi.org/10.1001/archotol.128.4.421
Shin SH, Heo WW. Effects of unilateral naris closure on the nasal and maxillary sinus mucosa in rabbit. Auris Nasus Larynx. 2005;32(2):139-143. https://doi.org/10.1016/j.anl.2005.01.015
Gadzhimirzaev GA. Allergicheskij rinit i bronhial’naya astma. Mahachkala; 2014. (In Russ.).
Gadzhimirzaev GA, Mihajlovskij MS, Bagomedov MM. Vliyanie odnostoronnego vyklyucheniya nosovogo dyhaniya na sostoyanie nizhnih dyhatel’nyh putej v eksperimente. Russian Bulletin of Otorhinolaryngology. 1981;(1):26-29. (In Russ.).