Meningoencephalocele (MEC) is a rare disease, the incidence of which varies from 0.008 to 0.03% in different countries. Transnasal endoscopic surgery using glue compositions is the method of choice in treating MEC. Objective: to evaluate the efficiency of surgical treatment using a biological fibrin-thrombin glue in patients with congenital ethmoidal MEC. Subjects and methods. The 20-year results of repair of skull base defects were studied in 24 patients with variously sized congenital ethmoidal MECs. The indications for the surgery were nasal liquorrhea or obstruction, or recurrent meningitis. The investigation included 2 groups: a control group consisting of 16 patients operated on without using the biological glue; and a study group comprising 8 patients operated on with the use of the fibrin-thrombin glue. Results. The defect was eliminated in all the patients. A disease recurrence occurred in 2 patients (one in each group), which required resurgery in one female patient in Group 1 (a control group) following 7 years and one female patient in Group 2 (a study group) 3 weeks after primary surgery. Its cause was elevated intracranial pressure that necessitated lumbar drainage. Conclusion. Application of the fibrin-thrombin glue had no substantial impact on the efficiency of surgical treatment for MEC, but when the glue was used, the surgical technique became simplified. The results of surgery for MEC do not differ greatly when the biological glue is used or not. The most important conditions for successful surgery for MEC are preoperative determination of a risk related to intracranial hypertension, as well as the quality of graft placement and fixation during the operation.