Introduction. Prevention of overweight (OW) and obesity among the adult population should be based on a clearer understanding of the relationships between weight, physical activity (PA), educational level, and social status. Objective — to assess the associations of PA with weight, type of obesity, educational level, and social status in a sample of 41—44-year-old males living in Moscow. Subjects and methods. The starting study material was a population sample of 301 males aged 41—44 years. The examination included a survey using the standard questionnaire, as well as anthropometry. The International Physical Activity Questionnaire (IPAQ) long form was employed to obtain information about PA. All the examinees were divided into groups according to weight, waist circumference (WC), educational level, social status, and the level and type of PA. The data were statistically processed using IBM SPSS Statistics 23.0 software. Results. Among the 41—44-year-old males, the incidence of OW was 38.2%; that of general and abdominal obesity was 28.9% each. The cumulative intensity of total PA was 3246 MET-min/week. The total PA was low in 30.3%, medium in 37.5%, and high in 32.2% of males. In people with obesity compared to those with normal weight, there was a smaller proportion of males having low PA (LPA) at work (62.1% versus 76.8%) and a larger proportion of those having LPA at leisure (43.7% versus 23.2%). A high inverse proportional association was found between WC and the level of leisure-time PA. In the group of higher education males, there was a larger proportion of individuals with LPA at work. A similar pattern was observed between social status and PA. The males with LPA at leisure compared to those with high PA at leisure were found to have statistically significant higher anthropometric indicators: weight, BMI, WC, and skinfold thickness. Conclusion. The findings can be used in the development of population preventive programs and in the individual counseling for patients with LPA and obesity.