Study of the association of genetic polymorphisms with the consumption of some nutrients

Baturin A.K.; Sorokina E.Yu.; Keshabyants E.E.; Kobelkova I.V.

doi:https://doi.org/10.17116/profmed20182106136

Baturin A.K.

Federal Research Center of Nutrition and Biotechnology, Moscow, Russia

Sorokina E.Yu.

Federal Research Center of Nutrition and Biotechnology, Moscow, Russia

Keshabyants E.E.

Federal Research Center of Nutrition and Biotechnology, Moscow, Russia

Kobelkova I.V.

Federal Research Center of Nutrition and Biotechnology, Moscow, Russia

Study of the association of genetic polymorphisms with the consumption of some nutrients

Authors:

Baturin A.K., Sorokina E.Yu., Keshabyants E.E., Kobelkova I.V.

More about the authors

Journal: Russian Journal of Preventive Medicine. 2018;21(6): 36‑41

DOI: 10.17116/profmed20182106136

Read: 1451 times

Download PDF (RU)

Contact the author

Table of contents

To cite this article:

Baturin AK, Sorokina EYu, Keshabyants EE, Kobelkova IV. Study of the association of genetic polymorphisms with the consumption of some nutrients. Russian Journal of Preventive Medicine. 2018;21(6):36‑41. (In Russ.)
https://doi.org/10.17116/profmed20182106136

Подписка 2026 Профилактическая медицина (Russian Journal of Preventive Medicine)

Использование инфографики авторами научных работ

Close metadata

Recommended articles:

Dental caries among 15-year-old adolescents in Arctic Russia: a systematic review and meta-analysis. Stomatology. 2024;(6):66-72

Abstract:

Thanks to the active introduction of molecular genetic technologies in healthcare practice, it became known that a genetic factor plays a significant role in human eating behavior. The paper presents the results of studies of an association between FTO rs9939609, ADRB3 rs4994, UCP2 rs659366, and KCNJ11 rs5219 polymorphisms in the population of the Arctic zone (Yamal-Nenets Autonomous Area) of the Russian Federation with the levels of fat, saturated fatty acids (SFAs), carbohydrates, and added sugar in the diet. The studies confirmed the presence of genetic traits in the inhabitants of this region and revealed the statistically significant association of the A allele of FTO rs9939609 polymorphism with the high content of SFAs in the diet, which is characteristic only for women. There were no statistical significant associations between FTO rs9939609, ADRB3 rs4994, UCP2 rs659366, KCNJ11 rs5219 polymorphisms and the levels of fat, carbohydrates, and added sugars in the diet of the examinees from the Arctic zone of the Russian Federation.

Keywords:

actual nutrition

FTO rs993609 polymorphism

UCP2 rs659366 polymorphism

ADRB3 rs5219 polymorphism

KCNJ11 rs5219 polymorphism

Arctic Zone

Yamal-Nenets Autonomous Area

Authors:

Baturin A.K.

Federal Research Center of Nutrition and Biotechnology, Moscow, Russia

Sorokina E.Yu.

Federal Research Center of Nutrition and Biotechnology, Moscow, Russia

Keshabyants E.E.

Federal Research Center of Nutrition and Biotechnology, Moscow, Russia

Kobelkova I.V.

Federal Research Center of Nutrition and Biotechnology, Moscow, Russia

Close metadata

References:

Oganov RG, Maslennikova GYa. The epidemics of cardiovascular diseases can be stopped by strengthening their prevention Prof. med. 2009;6:3-7. (In Russ.)
Izmailova OV, Kalinina AM, Eganyan RA. Alimentary-dependent risk factors of arterial hypertension and technologies for their correction (a review of literature). Prof. med. 2011;1:19-28. (In Russ.)
Hinney A, Volckmar AL. Genetics of eating disorders. Curr Psychiatry Rep. 2013;15:423. https://doi.org/10.1007/s11920-013-0423-y
Castellini G, Franzago M, Bagnoli S, Lelli L, Balsamo M, Mancini M, Benedetta Nacmias B, Ricca V, Sorbi S, Antonucci I, Stuppia L, Stanghellini G. Fat mass and obesity-associated gene (FTO) is associated to eating disorders susceptibility and moderates the expression of psychopathological traits. PloS ONE. 2017;12(3):e0173560. https://doi.org/10.1371/journal.pone.0173560
Lysenko V, Almgren P, Anevski D, et al. Genetic prediction of future type 2 diabetes. PloS Med. 2005;12:Article ID e345. https://doi.org/10.1371/journal.pmed.0020345
Yang Q, Xiao T, Guo J, Su Z. Complex Relationship between Obesity and the Fat Mass and Obesity Locus. Int J Biol Sci. 2017;13:615-620. https://doi.org/10.7150/ijbs.17051
Baturin AK, Sorokina EYu, Pogozheva AV, Peskova EV, Makurina ON, Tutel’yan VA. The investigation the combined effect of SNP rs9939609 (gene FTO) and rs4994 (gene ADRB3) polymorphisms on risk of obesity. Voprosy pitaniya. 2016;85(4):29-35. (In Russ.) http://vp.geotar.ru/ru/jarticles_diet/469.html?SSr=570133edc011ffffffff27c__07e204100b3914-4394
Lemas DJ, Klimentidis YC, Wiener HC, et al. Obesity polymorphisms identified in genome-wide association studies interact with n-3 polyunsaturated fatty acid intake and modify the genetic association with adiposity phenotypes in Yup’ik people. Genes Nutr. 2013;8:495-505. https://doi.org/10.1007/s12263-013-0340-z
Baturin AK, Sorokina EYu, Pogozheva AV, Keshabyants EE, Kobel’kova IV, Kambarov AO, Elizarova EV, Tutel’yan VA. The association of rs993609 polymorphisms of gene FTO and rs659366 polymorphisms of gene UCP2 with obesity among Arctic Russian population. Voprosy pitaniya. 2017;86(3):32-39. (In Russ.) https://vp.geotar.ru/ru/jarticles_diet/546.html?SSr=570133edc011ffffffff27c__07e204100b3914-4394
WHO. Fact sheet N394 Updated September 2015. Healthy diet. http://www.who.int/mediacentre/factsheets/fs394/en
Normy fiziologicheskoi potrebnosti v energii i pishchevykh veshchestvakh dlya razlichnykh grupp naseleniya Rossiiskoi Federatsii. Metodicheskie rekomendatsii MR 2.3.1.2432-08. 18 dekabrya 2008 g. (In Russ.) https://docs.cntd.ru/document/1200076084
Tanofsky-Kraff M, Han JC, Anandalingam K, Shomaker LB. The FTO gene rs9939609 obesity-risk allele and loss of control over eating. Am J Clin Nutr. 2009;90:1483-1488. https://doi.org/10.3945/ajcn.2009.28439
Fujisawa T, Ikegami H, Kawaguchi Y, Ogihara T. Metaanalysis of the association of Trp64Arg polymorphism of b3-adrenergic receptor gene with. J Clin Endocrinol Metab. 1998;83. https://doi.org/10.1210/jcem.83.7.4922
Li Qian, Kuanfeng X, Xinyu X, et al. UCP2 -866G/A, Ala55Val and UCP3 -55C/T Polymorphisms in Association with Obesity Susceptibility — A Metaanalysis Study. PLoS One. 2013;8:4:e58939. https://doi.org/10.1371%2Fjournal.pone.0058939
Baturin AK, Sorokina EYu, Pogozheva AV, Peskova EV, Makurina ON, Tutel’yan VA. The study of the association of polymorphism rs659366 gene UCP2 c obesity and type 2 diabetes among residents of the Moscow Region. Voprosy pitaniya. 2015;82(1):44-49. (In Russ.) https://vp.geotar.ru/ru/jarticles_diet/331.html?SSr=570133edc011ffffffff27c__07e204100b3914-4394
Lyssenko V, Jonsson A, Almgren P, Pulizzi N, Isomaa B, et al. Clinical risk factors, DNA variants, and the development of type 2 diabetes. N Engl J Med. 2008;359:2220-2232. https://doi.org/10.1056/NEJMoa0801869
Baturin AK, Sorokina EYu, Pogozheva AV, Peskova EV, Akurina ON, Tutelyan VA. The study of the association of polymorphism rs5219 gene KCNJ11 with obesity and the risk of type 2 diabetes among residents of the Moscow Region. Voprosy pitaniya. 2015;82(2):4-9. (In Russ.) https://vp.geotar.ru/ru/jarticles_diet/339.html?SSr=570133edc011ffffffff27c__07e204100b3914-4394
Cecil JE, Tavendale R,Watt P, et al. Obesity-associated FTO gene variant and increased energy intake in children. N Engl J Med. 2008;359 :2558-2566. https://doi.org/10.1056/NEJMoa0803839