The paper evaluates the impact of the first (in a series of three) mass media prophylaxis campaign on the knowledge, attitude, and behavior of young people aged 15-29 years, related to reproductive health and HIV/AIDS, which was conducted in 10 regions of the Russian Federation in 2005-2006. A quantitative study was performed using personal in-home interviews with respondents (4025 persons aged 15-29 years (50.4% men and 49.6% women) were interviewed). The study indicated that there was a reduction in misconception of the target group about the routes of HIV transmission, better awareness of the respondents about their risk for HIV infection and better attitude towards protection means; an increase in the number of respondents choosing safer behavioral models (a decrease in the number of sexual partners, refusal of unprotected sex, and the use of condoms). Information programs effectively support the desire of young people to behave more safely, positively affect their knowledge, attitude, and behavior, and are a reliable source of important information particularly for a 15-17-year-old group.