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Adamyan L.V.

Moscow State Medical and Dental University named after A.I. Evdokimov

Sibirskaya E.V.

Moscow State University of Medicine and Dentistry named after A.I. Evdokimov;
Russian Children’s Clinical Hospital — Pirogov Russian National Research Medical University;
Federal State Autonomous Educational Institution of Higher Education «Russian National Research Medical University named after N.I. Pirogov» of the Ministry of Health of Russia

Pivazyan L.G.

National medical research center for obstetrics, gynecology and perinatology named after academician V.I. Kulakov

Grdzelishvili A.A.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Murvatova K.K.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Role of kisspeptin in the pathogenesis of the functional hypothalamic amenorrhea

Authors:

Adamyan L.V., Sibirskaya E.V., Pivazyan L.G., Grdzelishvili A.A., Murvatova K.K.

More about the authors

Journal: Russian Journal of Human Reproduction. 2023;29(6): 81‑86

DOI: 10.17116/repro20232906181

Read: 1930 times

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Table of contents

ROLE OF KISSPEPTIN IN THE PATHOGENESIS OF THE FUNCTIONAL HYPOTHALAMIC AMENORRHEA
ROLE OF KISSPEPTIN IN THE PATHOGENESIS OF THE FUNCTIONAL HYPOTHALAMIC AMENORRHEA

To cite this article:

Adamyan LV, Sibirskaya EV, Pivazyan LG, Grdzelishvili AA, Murvatova KK. Role of kisspeptin in the pathogenesis of the functional hypothalamic amenorrhea. Russian Journal of Human Reproduction. 2023;29(6):81‑86. (In Russ.)
https://doi.org/10.17116/repro20232906181

Подписка 2026 Проблемы репродукции (Russian Journal of Human Reproduction)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Functional hypothalamic amenorrhea (FHA) is a pathological condition, characterized by the absence of menses for six and more months and anovulation, which has no organic causes. The neuropeptide kisspeptin plays a crucial role in the reproductive system by regulating secretion of gonadoropin-releasing hormone (GnRH) and the hypothalamic-pituitary-ovarian axis (HPO). This review examines the general characteristics of kisspeptin, including its structure, the KISS-1-receptor coupled with the GPR-54 protein, and the KNDy neurons, consisting of kisspeptin and cotranssmitters (neurokinin B and dynorphin). Furthermore, the relationship between kisspeptin/GPR-54 system and the development of FHA is discussed. The purpose of this review was to analyze role of kisspeptin in the pathogenesis of the functional hypothalamic amenorrhea.

Keywords:

functional hypothalamic amenorrhea
kisspeptin
KISS1R
KHDy neurons
reproductive system
hypothalamic-pituitary-gonadal axis

Authors:

Adamyan L.V.

Moscow State Medical and Dental University named after A.I. Evdokimov

Sibirskaya E.V.

Moscow State University of Medicine and Dentistry named after A.I. Evdokimov;
Russian Children’s Clinical Hospital — Pirogov Russian National Research Medical University;
Federal State Autonomous Educational Institution of Higher Education «Russian National Research Medical University named after N.I. Pirogov» of the Ministry of Health of Russia

Pivazyan L.G.

National medical research center for obstetrics, gynecology and perinatology named after academician V.I. Kulakov

Grdzelishvili A.A.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Murvatova K.K.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Received:

30.12.2022

Accepted:

11.05.2023

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References:

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