In the context of urbanization, everyday stress is increasingly the cause of menstrual disorders, which have a functional basis. Menstrual disorders caused by emotive factors are typical for adolescents and young women under the age of 25 years. Social jetlag disrupts the secretion of gonadotropin-releasing hormone. Changes in GnRH secretion leads to disruption of the hypothalamic-pituitary-ovarian axis, which affects the secretion of pituitary and ovarian hormones and changes the normal characteristics of the menstrual cycle. Drospirenone, as a gestogen in its properties close to progesterone and having a high affinity for progesterone receptors, can be used to control the functional activity of the hypothalamic-pituitary system due to the feedback effect. The pharmacological properties of this progestin open up the prospect of its use for the normalization of neuroendocrine dysfunction and menstrual cycle control. The available data suggest that YAZ with a shortened 4-day hormone-free interval can increase the reliability of contraception in clinical practice compared to the usual mode of use COC 21/7 days, as well as provide a higher efficiency in terms of such non-contraceptive effect, as the regulation of the menstrual cycle. Synthesis of neurotransmitters that determine the psycho-emotional state and behavioral reactions to stress occurs with the participation of folate-dependent coenzymes. Folate availability is one of the significant problems of micronutrient insufficiency in women of reproductive age. Despite the use of the strategy of fortification, the problem remains relevant. Taking into account that about 14% of women use hormonal contraception, the combination of COC + folates can significantly increase the number of women of reproductive age receiving a daily dose of folates. Folate have their own pharmacological effects, opening new perspectives for the use of the COC with metabolism stress induced menstrual irregularities due to the social jetlag.