Comparative evaluation of efficiency of different variants of the natural cycle and ovarian stimulation duringIVF/ICSI programs in patients with infertility

Boiarskiĭ K.Iu.

Klinika GENEZIS, Sankt-Peterburg

Gaidukov S.N.

Saint Petersburg State Pediatric Medical University, Ministry of Health of the Russian Federation, Saint Petersburg, Russia

Kachiani E.I.

The department of obstetrics and gynecology, North-Western State Medical University named after I.I. Mechnikov, St.-Petersburg, Russia, 191015

Dudnichenko T.A.

North-Western State Medical University, St.-Peterburg, Russia

Safina N.S.

North-Western State Medical University, St.-Peterburg, Russia

Comparative evaluation of efficiency of different variants of the natural cycle and ovarian stimulation duringIVF/ICSI programs in patients with infertility

Authors:

Boiarskiĭ K.Iu., Gaidukov S.N., Kachiani E.I., Dudnichenko T.A., Safina N.S.

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Journal: Russian Journal of Human Reproduction. 2019;25(1): 41‑48

DOI: 10.17116/repro20192501141

Downloaded: 43

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To cite this article:

Boiarskiĭ KIu, Gaidukov SN, Kachiani EI, Dudnichenko TA, Safina NS. Comparative evaluation of efficiency of different variants of the natural cycle and ovarian stimulation duringIVF/ICSI programs in patients with infertility. Russian Journal of Human Reproduction. 2019;25(1):41‑48. (In Russ.)
https://doi.org/10.17116/repro20192501141

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ABSTRACT In the comparative study 225 cycles of IVF/ICSI in 210 patients were investigated. The parameters of ovarian stimulation and outcomes were compared in the natural cycle, the modified natural cycle, mild (minimal) stimulation, and in the standard protocol with GnRH antagonists. On the initiated protocol, the frequency of clinical pregnancy was 10.2, 15.8, 30.8 and 45.4%, respectively. However, implantation rates did not differ statistically in all studied groups. OHSS was not observed in two groups of the natural cycle, with mild stimulation, 1.9% of cases and 27.3% in standard stimulation protocols were observed.

Keywords:

natural cycle IVF

modified protocol

moderate stimulation

standard protocol with antagonist GnRH

comparative study

Authors:

Boiarskiĭ K.Iu.

Klinika GENEZIS, Sankt-Peterburg

Gaidukov S.N.

Saint Petersburg State Pediatric Medical University, Ministry of Health of the Russian Federation, Saint Petersburg, Russia

Kachiani E.I.

The department of obstetrics and gynecology, North-Western State Medical University named after I.I. Mechnikov, St.-Petersburg, Russia, 191015

Dudnichenko T.A.

North-Western State Medical University, St.-Peterburg, Russia

Safina N.S.

North-Western State Medical University, St.-Peterburg, Russia

List of references:

Boyarsky KYu,Gaidukov SN, Chinchaladze AS. Factors which can predict ovarian reserve. Zhurnal akusherstva i zhenskikh boleznei. 2009;58(2):65-71. (In Russ.)
Kol S, Humaidan P. GnRH agonist triggering: recent developments. Reproductive Biomedicine Online. 2013;26(3):226-230. https://doi.org/10.1016/j.rbmo.2012.11.002
Blumenfeld Z. Why more is less and less is more when it comes to ovarian stimulation. Journal of Assisted Reproduction and Genetics. 2015;32(12):1713-1719. https://doi.org/10.1007/s10815-015-0599-7
Chen ZJ, Shi Y, Sun Y, Zhang B, Liang X, Cao Y, Yang J, Liu J, Wei D, Weng N, Tian L, Hao C, Yang D, Zhou F, Shi J, Xu Y, Li J, Yan J, Qin Y, Zhao H, Zhang H, Legro RS. Fresh versus frozen embryos for infertility in the polycystic ovary syndrome. New England Journal of Medicine. 2016;375(6):523-533. https://doi.org/10.1056/NEJMoa1513873
Nargund G, Fauser BC, Macklon NS, Ombelet W, Nygren K, Frydman R; Rotterdam ISMAAR Consensus Group on Terminology for Ovarian Stimulation for IVF. The ISMAAR proposal on terminology for ovarian stimulation for IVF. Human Reproduction. 2007;22(11):2801-2804. https://doi.org/10.1093/humrep/dem285
Gordon JD, DiMattina M, Reh A, Botes A, Celia G, Payson M. Utilization and success rates of unstimulated in vitro fertilization in the United States: an analysis of the Society for Assisted Reproductive Technology database. Fertility and Sterility. 2013;100(2):392-395. https://doi.org/10.1016/j.fertnstert.2013.03.037
What Effects Did Last Decade of New Treatments Have on IVF Outcomes? Accessed November 25, 2018. Available at: https://www.centerforhumanreprod.com/fertility/what-effects-did-last-decade-of-new-treatments-have-on-ivf-outcomes/
Hohmann FP, Laven JS, de Jong FH, Eijkemans MJ, Fauser BC. Low-dose exogenous FSH initiated during the early, mid or late follicular phase can induce multiple dominant follicle development. Human Reproduction. 2001;16(5):846-854. https://doi.org/10.1093/humrep/16.5.846
Hohmann FP, Macklon NS, Fauser BC. A randomized comparison of two ovarian stimulation protocols with gonadotropin-releasing hormone (GnRH) antagonist cotreatment for in vitro fertilization commencing recombinant follicle-stimulating hormone on cycle day 2 or 5 with the standard long GnRH agonist protocol. The Journal of Clinical Endocrinology & Metabolism. 2003;88:166-173. https://doi.org/10.1210/jc.2002-020788
Mathur R, Kailasam C, Jenkins J. Review of the evidence base of strategies to prevent ovarian hyperstimulation syndrome. Human Fertility. 2007;10(2):75-85. https://doi.org/10.1080/14647270601111239
Kamath MS, Maheshwari A, Bhattacharya S, Lor KY, Gibreel A. Oral medications including clomiphene citrate or aromatase inhibitors with gonadotropins for controlled ovarian stimulation in women undergoing in vitro fertilization. The Cochrane Database of Systematic Reviews. 2017;11:CD008528. https://doi.org/10.1002/14651858.CD008528.pub3

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